Missouri vs. Kansas Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 3:04 p.m. ET

Data Skrive

The Kansas Jayhawks (2-0) are 5.5-point underdogs heading into their matchup on Saturday, September 6, 2025 against the Missouri Tigers (1-0). The total has been set at 49.5 points for this game.

Last time around, the Tigers defeated the Central Arkansas Bears, with 61-6 being the final score. Last time around, the Jayhawks defeated the Wagner Seahawks, with 46-7 being the final score.

Keep up with college football all season on FOX Sports.

Missouri vs. Kansas Game Information & Odds

When: Saturday, September 6, 2025 at 3:30 p.m. ET
Location: Memorial Stadium/Faurot Field in Columbia, Missouri
TV: ESPN2
Live Box Score on FOX Sports

Missouri vs Kansas Betting Information updated as of September 6, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Missouri	-5.5 (-108)	-202	+167	49.5	-111	-109

Missouri vs. Kansas Prediction

Pick ATS: Pick Em
Pick OU: Over (49.5)
Prediction: Missouri 29, Kansas 24

Predictions are made by the Data Skrive betting model.

Learn more about the Missouri Tigers vs. the Kansas Jayhawks game on FOX Sports!

Missouri vs. Kansas Betting Insights

Based on the spread and over/under, the implied score for the tilt is Tigers 28, Jayhawks 22.
The Tigers have a 66.9% chance to win this contest based on the moneyline's implied probability. The Jayhawks have a 37.5% implied probability.
Missouri has won one game against the spread this season.
Kansas has a record of 1-1-0 against the spread this season.

Missouri vs. Kansas: 2025 Stats Comparison

	Missouri	Kansas
Off. Points per Game (Rank)	61 (11)	38.5 (4)
Def. Points per Game (Rank)	6 (17)	7 (55)
Turnovers Allowed (Rank)	0 (1)	2 (100)
Turnovers Forced (Rank)	2 (22)	3 (8)

Missouri 2025 Key Players

Name	Position	Stats
Beau Pribula	QB	283 YDS (82.1%) / 2 TD / 0 INT 65 RUSH YDS / 2 RUSH TD / 65 RUSH YPG
Marquis Johnson	WR	5 REC / 134 YDS / 1 TD / 134 YPG
Ahmad Hardy	RB	100 YDS / 1 TD / 100 YPG / 10 YPC
Jude James	TE	1 REC / 40 YDS / 1 TD / 40 YPG
Damon Wilson Jr.	DL	2 TKL / 2 TFL / 2 SACK
Jeremiah Beasley	LB	7 TKL / 0 TFL
Josiah Trotter	LB	8 TKL / 1 TFL
Dante McClellan	LB	3 TKL / 0 TFL / 1 INT / 1 PD

Kansas 2025 Key Players

Name	Position	Stats
Jalon Daniels	QB	456 YDS (80%) / 7 TD / 1 INT 65 RUSH YDS / 0 RUSH TD / 32.5 RUSH YPG
Cam Pickett	WR	8 REC / 106 YDS / 3 TD / 53 YPG
Emmanuel Henderson Jr.	WR	9 REC / 154 YDS / 2 TD / 77 YPG
Daniel Hishaw Jr.	RB	158 YDS / 1 TD / 79 YPG / 5.9 YPC
Lyrik Rawls	DB	7 TKL / 1 TFL / 1 INT / 1 PD
Bangally Kamara	LB	3 TKL / 1 TFL / 1 SACK
Leroy Harris III	DL	3 TKL / 2 TFL / 2 SACK
Devin Dye	DB	6 TKL / 0 TFL / 0.5 SACK / 1 INT