Louisiana Tech vs. Western Kentucky Prediction, Odds, Picks - October 21, 2025

Updated Oct. 21, 2025 3:04 p.m. ET

Data Skrive

The Louisiana Tech Bulldogs (4-2) are 3-point favorites when they host the Western Kentucky Hilltoppers (5-2) in conference play on Tuesday, October 21, 2025 at Joe Aillet Stadium. The contest has a point total of 49.5.

The Bulldogs' most recent game was against the Kennesaw State Owls, and they lost by a score of 35-7. Facing the Florida International Panthers in their most recent game, the Hilltoppers lost 25-6.

Keep up with college football all season on FOX Sports.

Louisiana Tech vs. Western Kentucky Game Information & Odds

When: Tuesday, October 21, 2025 at 7:30 p.m. ET
Location: Joe Aillet Stadium in Ruston, Louisiana
TV: CBS Sports Network
Live Box Score on FOX Sports

Louisiana Tech vs Western Kentucky Betting Information updated as of October 21, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisiana Tech	-3 (-115)	-163	+137	49.5	-115	-105

Louisiana Tech vs. Western Kentucky Prediction

Pick ATS: Louisiana Tech (-3)
Pick OU: Under (49.5)
Prediction: Louisiana Tech 33, Western Kentucky 15

Predictions are made by the Data Skrive betting model.

Learn more about the Louisiana Tech Bulldogs vs. the Western Kentucky Hilltoppers game on FOX Sports!

Louisiana Tech vs. Western Kentucky Betting Insights

Based on the spread and over/under, the implied score for the matchup is Bulldogs 26, Hilltoppers 23.
The Bulldogs have a 62.0% chance to collect the win in this meeting per the moneyline's implied probability. The Hilltoppers have a 42.2% implied probability.
Louisiana Tech has won five games against the spread this season, while failing to cover once.
Western Kentucky has put together a 5-2-0 record against the spread this year.

Louisiana Tech vs. Western Kentucky: Head-to-Head

The last two times Western Kentucky and Louisiana Tech have played, the two teams share a split 1-1 record.
In their most recent two matchups, each team has covered one time with those contests outpacing the point total on one occasion.
Louisiana Tech has been outpaced by 2 points in its last two tilts versus Western Kentucky.

Louisiana Tech vs. Western Kentucky: 2025 Stats Comparison

	Louisiana Tech	Western Kentucky
Off. Points per Game (Rank)	24.5 (106)	29.7 (58)
Def. Points per Game (Rank)	17.2 (12)	23.1 (61)
Turnovers Allowed (Rank)	7 (38)	10 (95)
Turnovers Forced (Rank)	13 (12)	8 (68)

Louisiana Tech 2025 Key Players

Name	Position	Stats
Blake Baker	QB	626 YDS (61.7%) / 3 TD / 1 INT 174 RUSH YDS / 2 RUSH TD / 34.8 RUSH YPG
Omiri Wiggins	RB	233 YDS / 3 TD / 38.8 YPG / 3.9 YPC 6 REC / 36 REC YDS / 1 REC TD / 9 REC YPG
Clay Thevenin	RB	261 YDS / 3 TD / 43.5 YPG / 4.3 YPC 7 REC / 52 REC YDS / 0 REC TD / 17.3 REC YPG
Eli Finley	TE	17 REC / 253 YDS / 0 TD / 42.2 YPG
Mekhi Mason	LB	21 TKL / 3 TFL / 3 SACK
Kolbe Fields	LB	15 TKL / 2 TFL / 2 SACK / 2 INT
Sifa Leota	LB	22 TKL / 2 TFL / 0.5 SACK / 1 INT
Michael Richard	DB	13 TKL / 2 TFL / 2 INT / 2 PD

Western Kentucky 2025 Key Players

Name	Position	Stats
Maverick McIvor	QB	1,863 YDS (67.3%) / 12 TD / 5 INT 28 RUSH YDS / 1 RUSH TD / 4 RUSH YPG
Matthew Henry	WR	23 REC / 435 YDS / 3 TD / 62.1 YPG
KD Hutchinson	WR	30 REC / 330 YDS / 3 TD / 47.1 YPG
La'Vell Wright	RB	207 YDS / 5 TD / 29.6 YPG / 5.2 YPC 7 REC / 63 REC YDS / 0 REC TD / 10.5 REC YPG
Jaylen Lewis	DB	19 TKL / 2 TFL / 2 INT / 2 PD
Jaylen Wester	LB	28 TKL / 1 TFL
Harper Holloman	DL	17 TKL / 2 TFL / 2 SACK
Anthony Brackenridge	LB	22 TKL / 2 TFL