Kansas vs. Cincinnati Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 9:04 a.m. ET

Data Skrive

The Kansas Jayhawks (3-1) host the Cincinnati Bearcats (2-1) on Saturday, September 27, 2025 in a matchup between Big 12 opponents at David Booth Kansas Memorial Stadium. Cincinnati is a 4.5-point underdog. The contest has a point total set at 56.5.

The Jayhawks beat the West Virginia Mountaineers, 41-10, in their last contest. In their last game, the Bearcats won against the Northwestern State Demons, 70-0.

Keep up with college football all season on FOX Sports.

Kansas vs. Cincinnati Game Information & Odds

When: Saturday, September 27, 2025 at 12 p.m. ET
Location: David Booth Kansas Memorial Stadium in Lawrence, Kansas
TV: TNT
Live Box Score on FOX Sports

Kansas vs Cincinnati Betting Information updated as of September 27, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Kansas	-4.5 (-113)	-203	+168	56.5	-110	-110

Kansas vs. Cincinnati Prediction

Pick ATS: Kansas (-4.5)
Pick OU: Under (56.5)
Prediction: Kansas 35, Cincinnati 15

Predictions are made by the Data Skrive betting model.

Learn more about the Kansas Jayhawks vs. the Cincinnati Bearcats game on FOX Sports!

Kansas vs. Cincinnati Betting Insights

Based on the spread and over/under, the implied score for the game is Jayhawks 30, Bearcats 26.
The Jayhawks have a 67.0% chance to collect the win in this game based on the moneyline's implied probability. The Bearcats have a 37.3% implied probability.
Kansas has won two games against the spread this season.
Cincinnati has a record of 2-1-0 against the spread this year.

Kansas vs. Cincinnati: 2025 Stats Comparison

	Kansas	Cincinnati
Off. Points per Game (Rank)	37.3 (22)	40.3 (59)
Def. Points per Game (Rank)	16.5 (39)	13.3 (13)
Turnovers Allowed (Rank)	3 (30)	3 (30)
Turnovers Forced (Rank)	6 (27)	1 (129)

Kansas 2025 Key Players

Name	Position	Stats
Jalon Daniels	QB	817 YDS (66.7%) / 12 TD / 2 INT 151 RUSH YDS / 1 RUSH TD / 37.8 RUSH YPG
Leshon Williams	RB	186 YDS / 2 TD / 62 YPG / 6.6 YPC 2 REC / 55 REC YDS / 1 REC TD / 27.5 REC YPG
Emmanuel Henderson Jr.	WR	18 REC / 221 YDS / 2 TD / 55.3 YPG
Cam Pickett	WR	11 REC / 132 YDS / 3 TD / 33 YPG
Trey Lathan	LB	26 TKL / 3 TFL / 1.5 SACK / 1 INT
Bangally Kamara	LB	13 TKL / 3 TFL / 1.5 SACK
Leroy Harris III	DL	9 TKL / 3 TFL / 3.5 SACK
Lyrik Rawls	DB	19 TKL / 1 TFL / 1 INT / 1 PD

Cincinnati 2025 Key Players

Name	Position	Stats
Brendan Sorsby	QB	655 YDS (70.3%) / 8 TD / 1 INT 175 RUSH YDS / 4 RUSH TD / 58.3 RUSH YPG
Cyrus Allen	WR	12 REC / 145 YDS / 3 TD / 48.3 YPG
Tawee Walker	RB	151 YDS / 1 TD / 50.3 YPG / 6.3 YPC 4 REC / 17 REC YDS / 1 REC TD / 5.7 REC YPG
Joe Royer	TE	8 REC / 138 YDS / 2 TD / 46 YPG
Jake Golday	LB	25 TKL / 2 TFL / 2 SACK
Jonathan Thompson	LB	16 TKL / 1 TFL / 1 SACK
Brian Simms III	LB	8 TKL / 2 TFL / 2 SACK
Antawn Peek Jr.	LB	9 TKL / 0 TFL