Colorado vs. Wyoming Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 9:04 p.m. ET

Data Skrive

The Colorado Buffaloes (1-2) are double-digit favorites (-11.5) on Saturday, September 20, 2025 against the Wyoming Cowboys (2-1). The over/under for the game is set at 45.5.

Last time around, the Buffaloes fell to the Houston Cougars, with 36-20 being the final score. Facing the Utah Utes in their last contest, the Cowboys lost 31-6.

Keep up with college football all season on FOX Sports.

Colorado vs. Wyoming Game Information & Odds

When: Saturday, September 20, 2025 at 10:15 p.m. ET
Location: Folsom Field in Boulder, Colorado
TV: ESPN
Live Box Score on FOX Sports

Colorado vs Wyoming Betting Information updated as of September 20, 2025, 8:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Colorado	-11.5 (-115)	-465	+354	45.5	-110	-110

Colorado vs. Wyoming Prediction

Pick ATS: Colorado (-11.5)
Pick OU: Under (45.5)
Prediction: Colorado 24, Wyoming 11

Predictions are made by the Data Skrive betting model.

Learn more about the Colorado Buffaloes vs. the Wyoming Cowboys game on FOX Sports!

Colorado vs. Wyoming Betting Insights

Per the spread and over/under, the implied score for the tilt is Buffaloes 28, Cowboys 17.
The Buffaloes have an 82.3% chance to collect the win in this meeting per the moneyline's implied probability. The Cowboys hold a 22.0% implied probability.
Colorado has a record of 1-2-0 against the spread this season.
Wyoming has covered twice in three chances against the spread this year.

Colorado vs. Wyoming: 2025 Stats Comparison

	Colorado	Wyoming
Off. Points per Game (Rank)	23.7 (105)	15.7 (122)
Def. Points per Game (Rank)	23.3 (66)	12.7 (24)
Turnovers Allowed (Rank)	2 (23)	4 (67)
Turnovers Forced (Rank)	5 (36)	4 (55)

Colorado 2025 Key Players

Name	Position	Stats
Kaidon Salter	QB	261 YDS (68.2%) / 1 TD / 0 INT 68 RUSH YDS / 2 RUSH TD / 34 RUSH YPG
Dekalon Taylor	RB	61 YDS / 0 TD / 20.3 YPG / 6.1 YPC 10 REC / 106 REC YDS / 2 REC TD / 35.3 REC YPG
Ryan Staub	QB	362 YDS (57.8%) / 3 TD / 2 INT 34 RUSH YDS / 0 RUSH TD / 17 RUSH YPG
Simeon Price	RB	135 YDS / 1 TD / 45 YPG / 7.1 YPC
Martavius French	LB	13 TKL / 2 TFL / 1 SACK
Tawfiq Byard	DB	18 TKL / 1 TFL / 0.5 SACK
Jeremiah Brown	LB	13 TKL / 1 TFL
Keaten Wade	DL	11 TKL / 3 TFL / 1 SACK

Wyoming 2025 Key Players

Name	Position	Stats
Chris Durr Jr.	WR	17 REC / 284 YDS / 2 TD / 94.7 YPG
Sam Scott	RB	203 YDS / 1 TD / 67.7 YPG / 4.6 YPC
Samuel Harris	RB	130 YDS / 1 TD / 43.3 YPG / 7.2 YPC 4 REC / 36 REC YDS / 0 REC TD / 18 REC YPG
Kaden Anderson	QB	535 YDS (58.5%) / 3 TD / 2 INT
Andrew Johnson	DB	18 TKL / 1 TFL / 1 SACK
Evan Eller	LB	17 TKL / 1 TFL / 1 INT / 1 PD
Ben Florentine	DL	6 TKL / 3 TFL / 3 SACK
Desman Hearns	DB	12 TKL / 0 TFL / 1 INT / 1 PD