2025-26 NBA Playoff Odds: Spreads, Lines for Second-Round Series

Now the NBA playoffs are in the swing of things.

Let's check out the odds for the second round of the playoffs, at DraftKings Sportsbook as of May 12.

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EAST SECOND ROUND

No. 7 PHILADELPHIA vs. No. 3 NEW YORK
NYK wins 4-0

No. 4 CLEVELAND (+125) vs. No. 1 DETROIT (-150) 
Tied 2-2

GAME 5 — CLE @ DET (May 12)

Spread: Pistons -3.5
Moneyline: Pistons -166, Cavs +140
O/U: 212.5

What to know: Is this one going seven? Neither team has been able to get a win on the others' home court, after Cleveland earned a nine-point win in Game 4. What was the interesting aspect of that game? The Cavs lost every quarter except the third (38-21), but that turned out to be enough to overcome the top-seeded Pistons.

WEST SECOND ROUND

No. 4 LOS ANGELES vs. No. 1 OKLAHOMA CITY
OKC wins 4-0

No. 6 MINNESOTA (+320) vs. No. 3 SAN ANTONIO (-390) 
Tied 2-2

GAME 5 — MIN @ SAS (May 12)

Spread: Spurs -10.5
Moneyline: Spurs -410, Wolves +320
O/U: 218.5

What to know: We've got a series on our hands. Now tied at 2-2, both of these teams have won once at home and once on the other team's home floor, with the Wolves winning a crucial Game 4 in Minnesota. But that wasn't the story of the night. Victor Wembanyama was assessed a Flagrant 2 in the first half of Game 4, and was ejected from the game, after hitting Naz Reid with a vicious elbow to the head. He will play Game 5, but how chippy might things be after that?