49ers vs. Colts MNF Live Score, Updates: Purdy, CMC Respond to Rivers' Hot Start

Two of the NFL's best will headline a Week 16 matchup with playoff implications, as Christian McCaffrey and the San Francisco 49ers meet Jonathan Taylor and the Indianapolis Colts inside Lucas Oil Stadium.

Neither star running back is being considered as the MVP frontrunner (we see you, Matthew Stafford), but they certainly belong on the short list of candidates. Taylor enters Monday Night Football ranked second in rushing yards (1,443) and first in total touchdowns (18), while McCaffrey—the receiving yards leader among RBs (820)—ranks 16th (922) and fourth (14) in those areas, respectively.

Add in an intriguing quarterback battle between Brock Purdy and 44-year-old Philip Rivers, in his second game after a five-year retirement, and this game could be special. The 49ers (10-4) secured a playoff berth Sunday but still have a shot at improving their seeding by beating a scrappy 8-6 Colts team fighting to stay in the picture.

Follow along below for all the highlights from 49ers vs. Colts on Monday night: