Dec 22, 2025 - 7:24p ET
National Football League
National Football League
49ers vs. Colts MNF Highlights: Purdy's Career Night, Rivers Pick-6 Sinks Indy
Updated: Dec 22, 2025 - 11:51 PM ET
Two of the NFL's best headlined a Week 16 matchup with playoff implications, as Christian McCaffrey and the San Francisco 49ers defeated Jonathan Taylor and the Indianapolis Colts, 48-27, at Lucas Oil Stadium.
McCaffrey outdueled Taylor, who entered Monday Night Football ranked second in rushing yards (1,443), and Brock Purdy turned in a career-best effort to lead the Niners to a big win.
Purdy's performance gave him the edge in an intriguing quarterback battle against 44-year-old Philip Rivers, who played valiantly in his second game after a five-year retirement. The 49ers (11-4) secured a playoff berth Sunday and have now improved their chances at the No. 1 seed by beating a scrappy 8-7 Colts team that may end up missing the postseason.
Check below for all the highlights from 49ers vs. Colts on Monday night!
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Dec 22, 2025 - 7:23p ET
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Dec 22, 2025 - 11:24p ET
End of Game: 49ers secure big win with pick-six
Dec 22, 2025 - 11:02p ET
Purdy notches new career-high mark with 49ers in control
Dec 22, 2025 - 10:48p ET
4th Quarter - 12:41: 49ers 34, Colts 27
Dec 22, 2025 - 10:40p ET
3rd Quarter - 1:45: Kittle announced as questionable
Dec 22, 2025 - 10:13p ET
Colts secondary no problem for Purdy
Dec 22, 2025 - 9:56p ET
Halftime: 49ers lead Colts, 24-17, after back-and-forth 1st half
Dec 22, 2025 - 9:21p ET
Purdy tosses 3rd TD of the night
Dec 22, 2025 - 9:03p ET
Rivers finds Pierce again for game-tying TD
Dec 22, 2025 - 8:47p ET
1st Quarter - 4:33: 49ers 14, Colts 7
Dec 22, 2025 - 8:42p ET
Purdy matches Rivers' game-opening TD; Niners follow with turnover on kickoff
Dec 22, 2025 - 8:32p ET
'Old Man' Rivers continues to shine
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