Packers vs. Browns 2025 Prediction, Odds, Picks - Sep 21

The Green Bay Packers (2-0) are considered favorites (-7.5) according to the bookmakers ahead of their game versus the Cleveland Browns (0-2) on September 21, 2025, starting at 1 p.m. ET, airing on FOX. The total for this one is set at 41.5 points.

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Packers vs. Browns Odds & Betting Lines

Packers vs. Browns Prediction & Pick

• Pick ATS: Packers (-7.5)
  
• Pick OU: Over (41.5)
  
• Prediction: Packers 30 - Browns 13

How to Watch Green Bay vs. Cleveland

• Game date: Sunday, September 21, 2025
• Time: 1 p.m. ET
• Venue: Huntington Bank Field
• Location: Cleveland, Ohio
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Packers vs. Browns Recent Matchups

• Green Bay owns a 2-0 record against Cleveland in their last two matchups.
• Cleveland has been outscored by 8 points in its last two tilts versus Green Bay.

Green Bay Betting Info

• Thus far this season, Green Bay is unbeaten against the spread.
• Green Bay games this year have not gone over the total in two opportunities.
• The Packers have been moneyline favorites in two other matchups this season, and they won both.
• Based on this matchup's moneyline, the Packers' implied win probability is 82.4%.

Packers Stats

Green Bay's Key Players

Offense

• Jordan Love has 480 passing yards, four touchdowns (eighth in the NFL) and zero interceptions this year. He has completed 66.0% of his passes, averaging 240.0 yards per game and 9.1 per attempt.
• Josh Jacobs averages 3.6 yards per carry (30th in the NFL) and 75.0 yards per game, and has 150 total rushing yards (eighth in the NFL). He has recorded two rushing TDs this season.
• Through two games played, Tucker Kraft is averaging 70.0 yards and 4.0 receptions per game to total 140 receiving yards and eight catches. He's been targeted 11 times, and has two receiving touchdowns (fifth in the NFL).
• Romeo Doubs has five catches for 96 yards and one touchdown. He's been targeted nine times in the passing game, and averages 2.5 receptions and 48.0 yards in two games played.

Defense

• Over on defense, Edgerrin Cooper has 22 tackles and 0.5 sacks in 2025. His tackle total leads the Packers and is fifth in the NFL.
• Rashan Gary has 10 tackles, 2.0 TFL, and 2.5 sacks this season. He's fourth on the Packers in tackles.
• Devonte Wyatt has recorded five tackles, 2.0 TFL, two sacks, and two passes defended.
• Quay Walker has 2.0 TFL and 17 tackles on the year.

Cleveland Betting Info

• Cleveland has covered the spread in a matchup one time this year (1-1-0).
• The Browns have been underdogs by 7.5 points or more one time this season and have not covered the spread once.
• Games involving Cleveland have hit the over once this year.
• The Browns have lost both games they've played as underdogs this season.
• Oddsmakers have implied with the moneyline set for this matchup that the Browns have a 21.7% chance to win.

Browns Stats

Cleveland's Key Players

Offense

• Joe Flacco is averaging 5.4 passing yards per attempt (30th in the NFL) and 244.5 yards per game this year, completing 62.2% of his passes on the way to 489 total yards, two touchdowns and three interceptions through two games.
• Cedric Tillman has put together a 2025 stat sheet that includes seven catches for 74 yards and two receiving touchdowns (fifth in the NFL) in two games played. He has been on the receiving end of 15 targets and is averaging 3.5 receptions per game.
• Dylan Sampson has yet to score a rushing touchdown this season, but has totaled 35 rushing yards (17.5 per game and 2.2 per carry).
• Sampson has helped out in the passing game, picking up 77 receiving yards (38.5 per game) on 11 catches (5.5 per game), while being targeted 11 times. He has one receiving touchdown.
• Jerry Jeudy has been targeted 16 times, resulting in nine catches for 117 yards and zero receiving touchdowns.

Defense

• Myles Garrett has 3.5 sacks (first on the Browns and first in the NFL) to go with 6.0 TFL and 10 tackles over two games in 2025.
• Devin Bush Jr.'s stats include 15 tackles, 2.0 TFL, one sack, and three passes defended.
• Greg Newsome II has 10 tackles, 1.0 TFL, and two passes defended in the 2025 campaign.
• Isaiah McGuire has 1.0 sack (second on the Browns) to go with 2.0 TFL and seven tackles over two games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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