Lions vs. Buccaneers 2025 Prediction, Odds, Picks - Oct 20

The Detroit Lions (4-2) are favored by 6.5 points against the Tampa Bay Buccaneers (5-1) on October 20, 2025, starting at 7 p.m. ET, airing on ABC/ESPN. The over/under for this one is set at 53.5 points.

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Lions vs. Buccaneers Odds & Betting Lines

Lions vs. Buccaneers Prediction & Pick

• Pick ATS: Buccaneers (+6.5)
  
• Pick OU: Over (53.5)
  
• Prediction: Lions 28 - Buccaneers 27

How to Watch Detroit vs. Tampa Bay

• Game date: Monday, October 20, 2025
• Time: 7 p.m. ET
• Venue: Ford Field
• Location: Detroit, Michigan
• TV: ABC/ESPN
• Live Boxscore: FOX Sports

Lions vs. Buccaneers Recent Matchups

• Detroit has a 3-2 record against Tampa Bay in their last five matchups.
• Detroit and Tampa Bay have matched up evenly on offense over their past five matchups, with each team scoring 108 total points in those games.

Detroit Betting Info

• Detroit has played six games, posting four wins against the spread.
• The Lions have been favored by 6.5 points or more two times this season, and covered the spread in both.
• Detroit games in 2025 have gone over the point total three times in six opportunities (50%).
• The Lions were the moneyline favorite three times this season, and won each of those games.
• The implied probability in this matchup, considering the moneyline, gives the Lions a 74.0% chance to win.

Lions Stats

Detroit's Key Players

Offense

• Jared Goff has thrown for 1,390 yards, 14 touchdowns (third in the NFL) and two interceptions this year. He averages 231.7 yards per game and 8 per attempt, while completing 75.9% of his attempts.
• Amon-Ra St. Brown has caught 44 passes (sixth in the NFL) on 51 targets for 452 total yards and six touchdowns. He is averaging 7.3 catches and 75.3 yards per game through six games.
• Jahmyr Gibbs' output on the ground this season includes 390 yards and four TDs. He is averaging 65 yards per game and 4.5 per attempt (17th in the NFL).
• Gibbs has 23 catches on 25 targets for 112 yards, with one receiving TD.
• David Montgomery has run for 334 yards, averaging 55.7 yards per game and scoring four touchdowns.
• He has added nine catches (on 10 targets) for 78 receiving yards with zero touchdowns. He's averaging 13 receiving yards and 1.5 receptions per game.

Defense

• On the defensive side, Jack Campbell has 54 tackles, three TFL, and two sacks in 2025.
• Aidan Hutchinson has 14 tackles, six TFL, and six sacks.
• This season, Alex Anzalone has recorded 1.5 sacks (fifth on the Lions) in addition to his one TFL, 35 tackles, and one interception.
• Derrick Barnes has two sacks (third on the Lions) in addition to his two TFL and 35 tackles on the year.

Tampa Bay Betting Info

• Tampa Bay has registered a 4-2-0 record against the spread this year.
• Tampa Bay's games have finished with a final combined score above the over/under four times this year.
• The Buccaneers have entered the game as underdogs three times this season and won twice.
• Sportsbooks have implied with the moneyline set for this matchup that the Buccaneers have a 30.3% chance to win.

Buccaneers Stats

Tampa Bay's Key Players

Offense

• Baker Mayfield is averaging 7.9 passing yards per attempt (seventh in the NFL) and 256.5 yards per game this year, completing 66.2% of his passes on the way to 1,539 total yards (10th in the NFL), 12 touchdowns (seventh in the NFL) and one interception through six games.
• On the ground, Mayfield has added 158 rushing yards (third on the Buccaneers).
• Emeka Egbuka has put together a 2025 campaign that includes 27 catches for 469 yards (eighth in the NFL) and five receiving touchdowns (fifth in the NFL) in six games played. He has been on the receiving end of 42 targets and is averaging 4.5 receptions per game.
• Rachaad White has rushed for four touchdowns this year, and has totaled 214 rushing yards (35.7 per game and 4 per attempt).
• White has helped in the receiving game, putting up 85 receiving yards (14.2 per game) on 15 catches (2.5 per game), while being targeted 16 times. He is trying for his first receiving touchdown.
• Bucky Irving is scoreless on the ground, but has rushed for 237 total yards (3.3 per attempt and 59.3 per game).
• Irving has also caught 19 passes for 193 yards (third on the Buccaneers), with two receiving touchdowns. He's been targeted 19 times and averages 48.3 yards per game.

Defense

• In 2025, Lavonte David has 40 tackles, five TFL, 2.5 sacks, and one interception over six games.
• Tykee Smith has 45 tackles, two TFL, one sack, and seven passes defended.
• SirVocea Dennis has five TFL and 40 tackles in the 2025 campaign.
• Jacob Parrish's season stats include 28 tackles, three TFL, and one sack in six games. He is fifth on the Buccaneers in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Detroit Lions

Tampa Bay Buccaneers