Colts vs. Steelers 2025 Prediction, Odds, Picks - Nov 2

The Indianapolis Colts (7-1) are the favorites, expected to win by at least a field goal but less than a touchdown (currently -3.5) over the Pittsburgh Steelers (4-3). The Colts have taken four games straight. The total for this one is set at 52.5 points.

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Colts vs. Steelers Odds & Betting Lines

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Colts vs. Steelers Prediction & Pick

• Pick ATS: Colts (-3.5)
  
• Pick OU: Under (52.5)
  
• Prediction: Colts 32 - Steelers 19

How to Watch Indianapolis vs. Pittsburgh

• Game date: Sunday, November 2, 2025
• Time: 1 p.m. ET
• Venue: Acrisure Stadium
• Location: Pittsburgh, Pennsylvania
• TV: CBS
• Live Boxscore: FOX Sports

Colts vs. Steelers Recent Matchups

• In their last five head-to-head matchups, Pittsburgh has beaten Indianapolis three times.
• Over their last five head-to-head contests, Indianapolis has racked up 115 points, while Pittsburgh has accumulated 107.

Indianapolis Betting Info

• Indianapolis has played eight games, posting six wins against the spread.
• The Colts have covered the spread three times this season (3-1 ATS) when playing as at least 3.5-point favorites.
• Indianapolis games this year have gone over the total in five out of eight opportunities (62.5%).
• The Colts have yet to lose a game they played as the moneyline favorite, going 5-0 in those matchups this season.
• The Colts have an implied win probability, based on the moneyline, of 64.9%.

Colts Stats

Indianapolis' Key Players

Offense

• Jonathan Taylor's rushing output this season includes 850 yards (first in the NFL) and 12 TDs. He is averaging 106.3 yards per game and 5.9 per attempt (second in the NFL).
• Taylor has been targeted 27 times in the receiving game and has 25 catches (3.1 per game) for 206 yards (25.8 per game) and two TDs.
• Daniel Jones has passed for 2,062 yards (fourth in the NFL), 13 touchdowns and three interceptions this year. He averages 257.8 yards per game and 8.5 per attempt, while completing 71.2%.
• He has rushed for 86 yards (second on the Colts) and added four touchdowns on the ground, while averaging 10.8 rushing yards per game.
• In the passing attack, Michael Pittman Jr., has contributed with 446 receiving yards and six touchdowns (third in the NFL) after hauling in 43 balls on 56 targets. Per game, he's averaging 55.8 yards and 5.4 receptions in eight games.
• Tyler Warren has 37 receptions for 492 yards and three touchdowns. He's been targeted 50 times in the air attack, and averages 4.6 receptions and 61.5 yards through eight games played.

Defense

• Over on defense, DeForest Buckner has 38 tackles, eight TFL, and four sacks in 2025.
• Nick Cross has 1.5 sacks as well as four TFL, 56 tackles, and one interception.
• Mekhi Blackmon has recorded 37 tackles, one TFL, one sack, and two interceptions this year.
• So far this season, Zaire Franklin has 44 tackles, one TFL, and one sack. He's third on the Colts in tackles.

Pittsburgh Betting Info

• Pittsburgh has put together a 3-4-0 record against the spread this season.
• Pittsburgh games have gone over the total five times this season.
• The Steelers have split the two games they've played as underdogs this season.
• Sportsbooks have implied with the moneyline set for this matchup that the Steelers have a 39.4% chance to win.

Steelers Stats

Pittsburgh's Key Players

Offense

• Aaron Rodgers has passed for 1,489 yards this year, with 16 touchdowns (third in the NFL) and five interceptions. He is completing 68.3% of his passes while averaging 212.7 yards per game and 7.2 per attempt.
• D.K. Metcalf has put together a 2025 stat sheet that includes 27 catches for 461 yards and five receiving touchdowns (eighth in the NFL) in seven games played. He has been on the receiving end of 43 targets and is averaging 3.9 receptions per game.
• Jaylen Warren has yet to score a rushing touchdown this season, but has totaled 373 rushing yards (62.2 per game and 4.5 per attempt).
• Jaylen Warren's offensive output includes 19 receptions (3.2 per game) on 22 targets for 195 yards (32.5 per game) and one receiving touchdown.
• Kenneth Gainwell has 221 rushing yards (second on the Steelers) and three rushing touchdowns, while averaging 31.6 yards per game and 4.5 per carry (20th in the NFL).
• Gainwell also has 84 receiving yards (12 per game) on 23 catches (3.3 per game). He has been targeted 26 times while he is still seeking his first receiving touchdown.

Defense

• T.J. Watt has intercepted one pass to go with 31 tackles, five TFL, four sacks, and four passes defended in 2025.
• Payton Wilson's stats include 50 tackles, five TFL, and one sack.
• In the 2025 season, Nick Herbig has 16 tackles, six TFL, 4.5 sacks, and one interception through six games.
• Patrick Queen has one sack as well as five TFL and 51 tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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