Colts vs. Jaguars 2025 Prediction, Odds, Picks - Dec 7

The Indianapolis Colts (8-4) are small favorites (-1.5) over the Jacksonville Jaguars (8-4), despite the Jaguars having taken three games straight. The expected point total for the game is 46.5.

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Colts vs. Jaguars Odds & Betting Lines

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Colts vs. Jaguars Prediction & Pick

• Pick ATS: Jaguars (+1.5)
  
• Pick OU: Over (46.5)
  
• Prediction: Jaguars 25 - Colts 23

How to Watch Indianapolis vs. Jacksonville

• Game date: Sunday, December 7, 2025
• Time: 1 p.m. ET
• Venue: EverBank Stadium
• Location: Jacksonville, Florida
• TV: CBS
• Live Boxscore: FOX Sports

Colts vs. Jaguars Recent Matchups

• Jacksonville holds a 3-2 record against Indianapolis in their last five matchups.
• Indianapolis has been outscored by 20 points in its last five tilts versus Jacksonville.

Indianapolis Betting Info

• Indianapolis has played 12 games, posting seven wins against the spread.
• The Colts have covered the spread four times this season (4-4 ATS) when playing as at least 1.5-point favorites.
• Indianapolis has combined with its opponent to gone over the point total in 50% of its contests this year (six times in 12 games with a set point total).
• When playing as the moneyline favorite, the Colts are 6-2, earning a win 75% of the time.
• The implied probability for this matchup, considering the moneyline, gives the Colts a 56.5% chance to win.

Colts Stats

Indianapolis' Key Players

Offense

• On the ground, Jonathan Taylor averages 5.7 yards per attempt (first in the NFL) and 106.8 yards per game for 1,282 total rushing yards (first in the NFL). He has recorded 15 rushing touchdowns this season.
• He has hauled in 35 passes (on 40 targets) for 304 receiving yards with two touchdowns. He's averaging 25.3 receving yards and 2.9 catches per game.
• Daniel Jones has thrown for 3,041 yards (sixth in the NFL), 19 touchdowns (seventh in the NFL) and seven interceptions this year. He is averaging 253.4 yards per game and 8.1 per attempt, while completing 67.9%.
• He's also rushed for 160 yards (second on the Colts) and added five touchdowns on the ground, while averaging 13.3 rushing yards per game.
• Michael Pittman Jr. has seven touchdown catches this season (fifth in the NFL), and has 60 catches for 620 yards on 82 targets, while averaging five catches and 51.7 yards per game.
• Tyler Warren has 58 catches for 684 yards and four touchdowns. He's been targeted 78 times in the air attack, and averages 4.8 receptions and 57 yards in 12 games played.

Defense

• On defense for the Colts, Zaire Franklin has racked up 87 tackles, four TFL, and two sacks in 2025.
• Germaine Pratt has five TFL and 92 tackles.
• Nick Cross has collected 83 tackles, four TFL, 2.5 sacks, and one interception this year. He's third on the Colts in tackles.
• Laiatu Latu has three interceptions (eighth in the NFL) while adding 33 tackles, six TFL, 5.5 sacks, and four passes defended.

Jacksonville Betting Info

• Jacksonville is 7-5-0 against the spread this year.
• The Jaguars are 3-3 ATS when underdogs by 1.5 points or more this year.
• This season, six Jacksonville games have gone over the point total.
• The Jaguars have entered the game as underdogs six times this season and won three of those games.
• Sportsbooks have implied with the moneyline set for this matchup that the Jaguars have a 47.6% chance to win.

Jaguars Stats

Jacksonville's Key Players

Offense

• Trevor Lawrence has passed for 2,636 yards this year, with 16 touchdowns and 11 interceptions. He is completing 59.7% of his attempts while averaging 219.7 yards per game and 6.7 per attempt.
• He's added 235 yards on the ground (third on the Jaguars), with five rushing touchdowns. He's averaging 19.6 yards per game and 4.1 per attempt.
• Travis Etienne averages 70.3 rushing yards per game over 12 games (843 total yards), while scoring five rushing touchdowns.
• Etienne has added 25 receptions (2.1 per game) for 173 yards (14.4 per game) with two receiving touchdowns. He's been targeted 38 times in the passing attack.
• Parker Washington has put up 447 receiving yards and three touchdowns on 36 receptions, while being targeted 63 times on the season.
• Jakobi Meyers has 51 catches for 597 yards and two receiving touchdowns. He averages 4.6 yards per game in 11 games and has been targeted 70 times.

Defense

• In 2025, Foyesade Oluokun has recorded 96 tackles, five TFL, one sack, and one interception over 12 games.
• Josh Hines-Allen has 33 tackles, 10 TFL, six sacks, and two passes defended.
• Devin Lloyd has 45 tackles, five TFL, 1.5 sacks, and four interceptions in the 2025 season. He is third on the Jaguars in tackles.
• Andrew Wingard has totaled one TFL, 72 tackles, and one interception.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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