Colts vs. Jaguars 2025 Prediction, Odds, Picks - Dec 7

The Jacksonville Jaguars (8-4) will be trying to extend a three-game winning run against the Indianapolis Colts (8-4). Despite that, the Colts are small favorites (-2.5). An over/under of 45.5 points has been established for the matchup.

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Colts vs. Jaguars Odds & Betting Lines

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Colts vs. Jaguars Prediction & Pick

• Pick ATS: Jaguars (+2.5)
  
• Pick OU: Over (45.5)
  
• Prediction: Jaguars 25 - Colts 23

How to Watch Indianapolis vs. Jacksonville

• Game date: Sunday, December 7, 2025
• Time: 1 p.m. ET
• Venue: EverBank Stadium
• Location: Jacksonville, Florida
• TV: CBS
• Live Boxscore: FOX Sports

Colts vs. Jaguars Recent Matchups

• In their last five head-to-head bouts, Jacksonville has beaten Indianapolis three times.
• Over their last five head-to-head matchups, Jacksonville has put up 155 points, while Indianapolis has accumulated 135.

Indianapolis Betting Info

• Indianapolis has played 12 games, posting seven wins against the spread.
• The Colts have been favored by 2.5 points or more seven times this season, and covered the spread in three of those matchups.
• Indianapolis games this year have hit the over on six of 12 set point totals (50%).
• When playing as moneyline favorites, the Colts are 6-2, winning 75% of the time.
• Looking at this contest's moneyline, the Colts' implied win probability is 57.4%.

Colts Stats

Indianapolis' Key Players

Offense

• Jonathan Taylor has put up 1,282 rushing yards (first in the NFL) with 15 touchdowns (106.8 yards per game through 12 games). His 5.7 yards per attempt lead in the NFL.
• Taylor has 40 targets, 35 catches, 304 receiving yards and two TDs through the air.
• Daniel Jones has 3,041 passing yards (sixth in the NFL), 19 touchdowns (seventh in the NFL) and seven interceptions this year. He has completed 67.9% of his attempts, averaging 253.4 yards per game and 8.1 per attempt.
• He's rushed for 160 yards (second on the Colts) and added five touchdowns on the ground, while averaging 13.3 rushing yards per game.
• Michael Pittman Jr. has seven touchdown catches this season (fifth in the NFL), and has 60 receptions for 620 yards on 82 targets, while averaging five catches and 51.7 yards per game.
• Tyler Warren has put up 684 receiving yards and four touchdowns with 58 catches on 78 targets. He's averaging 4.8 receptions and 57 yards per game.

Defense

• Over on defense, Zaire Franklin has 87 tackles, four TFL, two sacks, and four passes defended in 2025.
• Germaine Pratt has 92 tackles, five TFL, and six passes defended.
• Nick Cross has put up 83 tackles, four TFL, 2.5 sacks, and one interception this year. He's third on the Colts in tackles.
• So far this season, Laiatu Latu has 33 tackles, six TFL, 5.5 sacks, and three interceptions.

Jacksonville Betting Info

• Jacksonville has registered a 7-5-0 record against the spread this year.
• So far this year, the Jaguars have been installed as underdogs by a 2.5-point margin or more five times and are 3-2 ATS in those matchups.
• This year, Jacksonville games have hit the over six times.
• This season, the Jaguars have been the underdog six times and won three of those games.
• The moneyline for this contest implies a 46.7% chance of a victory for the Jaguars.

Jaguars Stats

Jacksonville's Key Players

Offense

• Trevor Lawrence is averaging 6.7 passing yards per attempt (23rd in the NFL) and 219.7 yards per game this year, completing 59.7% of his passes on the way to 2,636 total yards, 16 touchdowns and 11 interceptions through 12 games.
• He's added 235 yards on the ground (third on the Jaguars), while scoring five rushing touchdowns. He's averaging 19.6 yards per game and 4.1 per attempt.
• Travis Etienne has 843 rushing yards (leading the Jaguars) and five rushing touchdowns, while averaging 70.3 yards per game and 4.7 per attempt (13th in the NFL).
• Etienne also has 25 catches for 173 yards (seventh on the Jaguars), with two receiving touchdowns. He has been targeted 38 times and averages 14.4 yards per game.
• Parker Washington has recorded 447 receiving yards and three touchdowns on 36 receptions, while being targeted 63 times on the season.
• Jakobi Meyers has 51 catches for 597 yards and two receiving touchdowns. He averages 4.6 yards per game through 11 games and has been targeted 70 times.

Defense

• Foyesade Oluokun has one sack to go with five TFL, 96 tackles, and one interception over 12 games in 2025.
• Josh Hines-Allen has 33 tackles, 10 TFL, six sacks, and two passes defended.
• Devin Lloyd has 1.5 sacks (fifth on the Jaguars) in addition to his five TFL, 45 tackles, and four interceptions.
• Andrew Wingard has one TFL, 72 tackles, and one interception through 12 games.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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