Chiefs vs. Commanders 2025 Prediction, Odds, Picks - Oct 27

Updated Oct. 27, 2025 4:43 p.m. ET

Data Skrive

The Kansas City Chiefs (4-3) are considered favorites (-11.5) according to the oddsmakers ahead of their game against the Washington Commanders (3-4) on October 27, 2025, starting at 8:15 p.m. ET, airing on ABC/ESPN. An over/under of 48.5 points has been established for the matchup.

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Chiefs vs. Commanders Odds & Betting Lines

Chiefs vs Commanders Betting Information updated as of October 27, 2025, 4:33 p.m. ET.
Favorite	Spread	Favorite Spread Odds	Underdog Spread Odds	Total	Over Total Odds	Under Total Odds
Chiefs	-11.5	-107	-124	48.5	-105	-115

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Chiefs vs. Commanders Prediction & Pick

Pick ATS: Chiefs (-11.5)
Pick OU: Under (48.5)
Prediction: Chiefs 30 - Commanders 17

How to Watch Kansas City vs. Washington

Game date: Monday, October 27, 2025
Time: 8:15 p.m. ET
Venue: GEHA Field at Arrowhead Stadium
Location: Kansas City, Missouri
TV: ABC/ESPN
Live Boxscore: FOX Sports

Chiefs vs. Commanders Recent Matchups

In their past two head-to-head matchups, Kansas City has taken down Washington two times.
Washington has been outpaced by 27 points in its last two tilts against Kansas City.

Kansas City Betting Info

Kansas City is 4-3-0 against the spread this season.
The Chiefs have won their only game this season when playing as at least 11.5-point favorites.
Kansas City games this year have gone over the total in three out of seven opportunities (42.9%).
When playing as the moneyline favorite, the Chiefs are 3-2 (winning 60% of the time).
Based on this matchup's moneyline, the Chiefs' implied win probability is 87.5%.

Chiefs Stats

Stat	Average (Total)	Rank
Pass yards	247.1 (1,730)	6
Rush yards	123.4 (864)	10
Points scored	26.6 (186)	12
Pass yards against	174.6 (1,222)	3
Rush yards against	105.7 (740)	13
Points allowed	17.7 (124)	3

Kansas City's Key Players

Offense

Patrick Mahomes has thrown for 1,800 yards (eighth in the NFL), 14 touchdowns (10th in the NFL) and two interceptions this year. He is averaging 257.1 yards per game and 7.3 per attempt, while completing 66.1% of his passes.
He has also rushed for 250 yards (second on the Chiefs) and added four touchdowns on the ground, while averaging 35.7 rushing yards per game.
Marquise Brown's 316 receiving yards this season have come from 48 targets and 32 receptions. He's averaging 45.1 receiving yards and 4.6 catches per game, with four receiving touchdowns.
In the passing game, Travis Kelce, has totaled 375 receiving yards and two touchdowns after pulling down 31 balls on 40 targets. Per game, he's averaging 53.6 yards and 4.4 receptions over seven games.
Tyquan Thornton has 14 catches for 311 yards and three touchdowns. He's been targeted 27 times in the air attack, and averages 2.3 receptions and 51.8 yards in six games played.

Defense

On defense for the Chiefs, Nick Bolton has powered the unit with 55 tackles and four TFL in 2025.
George Karlaftis III has 23 tackles, six TFL, and 3.5 sacks this season.
Chamarri Conner has totaled 47 tackles this year.
This season, Drue Tranquill has 31 tackles, four TFL, and two sacks. He's fourth on the Chiefs in tackles.

Washington Betting Info

Washington has compiled a 3-4-0 record against the spread this season.
Washington's games have finished with a final combined score above the over/under three times this year.
This season, the Commanders have won one out of the four games in which they've been the underdog.
Sportsbooks have implied with the moneyline set for this matchup that the Commanders have a 16.7% chance to win.

Commanders Stats

Stat	Average (Total)	Rank
Pass yards	196.1 (1,373)	24
Rush yards	148.9 (1,042)	2
Points scored	25.7 (180)	13
Pass yards against	238.3 (1,668)	26
Rush yards against	126 (882)	21
Points allowed	24.3 (170)	21

Washington's Key Players

Offense

Through five games played this year, Jayden Daniels has totaled 1,031 passing yards, while throwing eight touchdowns against one interception and completing 61% of his attempts.
On the ground, Daniels has added one rushing touchdown and 211 rushing yards (second on the Commanders).
Jacory Croskey-Merritt has scored four rushing touchdowns, while totaling 377 rushing yards (5.2 per carry and 53.9 per game).
Deebo Samuel has recorded 315 receiving yards and three touchdowns on 34 receptions, while being targeted 43 times on the season.
Zach Ertz has been targeted 34 times, resulting in 23 catches for 229 yards .

Defense

Bobby Wagner has recorded two sacks (third on the Commanders) to go with five TFL and 73 tackles through seven games in 2025.
Frankie Luvu has 40 tackles, four TFL, two sacks, and one pass defended.
Mike Sainristil has 31 tackles and two interceptions.
Da'Ron Payne has 26 tackles, five TFL, one sack, and five passes defended.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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