Bills vs. Steelers 2025 Prediction, Odds, Picks - Nov 30

The Buffalo Bills (7-4) are favored by three points against the Pittsburgh Steelers (6-5) on November 30, 2025, starting at 4:25 p.m. ET, airing on CBS. An over/under of 44.5 points has been established for the matchup.

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Bills vs. Steelers Odds & Betting Lines

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Bills vs. Steelers Prediction & Pick

• Pick ATS: Steelers (+3)
  
• Pick OU: Over (44.5)
  
• Prediction: Bills 26 - Steelers 25

How to Watch Buffalo vs. Pittsburgh

• Game date: Sunday, November 30, 2025
• Time: 4:25 p.m. ET
• Venue: Acrisure Stadium
• Location: Pittsburgh, Pennsylvania
• TV: CBS
• Live Boxscore: FOX Sports

Bills vs. Steelers Recent Matchups

• Over their last four meetings, Buffalo has totaled three wins against Pittsburgh.
• Over their last four head-to-head contests, Buffalo has scored 102 points, while Pittsburgh has posted 53.

Buffalo Betting Info

• In 11 Buffalo games this season, it has five wins against the spread.
• The Bills have been favored by 3 points or more nine times this season, and covered the spread in three of those matchups.
• Buffalo games this year have hit the over on five of 11 set point totals (45.5%).
• When playing as the moneyline favorite, the Bills are 5-4 (winning 55.6% of the time).
• The implied probability for this matchup, considering the moneyline, gives the Bills a 62.4% chance to win.

Bills Stats

Buffalo's Key Players

Offense

• Josh Allen has 2,709 passing yards (10th in the NFL), 18 touchdowns and nine interceptions this year. He has completed 69.7% of his attempts, averaging 246.3 yards per game and 8.3 per attempt.
• In addition to his passing statistics, Allen also has 371 rushing yards (second on the Bills), with 10 rushing touchdowns.
• James Cook averages 5.4 yards per carry (fourth in the NFL) and 98.5 yards per game, and has 1,084 total rushing yards (second in the NFL). He has recorded eight rushing TDs this season.
• Cook has 24 catches on 26 targets for 203 yards. He has one receiving TD.
• In the passing game, Khalil Shakir, has racked up 564 receiving yards and three touchdowns after hauling in 54 balls on 71 targets. Per game, he's averaging 51.3 yards and 4.9 receptions in 11 games.
• Dalton Kincaid has racked up 448 receiving yards and four touchdowns with 29 catches on 36 targets. He is averaging 3.6 receptions and 56.0 yards per game.

Defense

• On the defensive side for the Bills, Cole Bishop has powered the unit with 60 tackles, 3.0 TFL, two sacks, and three interceptions in 2025.
• Terrel Bernard has 57 tackles, 7.0 TFL, and one interception this season. He's second on the Bills in tackles.
• This season, Joey Bosa has recorded 4.0 sacks (first on the Bills) to go with 7.0 TFL and 24 tackles.
• Greg Rousseau has 3.0 sacks (second on the Bills) to go with 3.0 TFL and 35 tackles on the year.

Pittsburgh Betting Info

• Pittsburgh is 5-6-0 against the spread this season.
• This year, the Steelers have one ATS win in two games as an underdog of 3 points or more.
• This season, six Pittsburgh games have gone over the point total.
• The Steelers have won two of the five games they've played as underdogs this season.
• The bookmakers' moneyline implies a 41.7% chance of a victory for the Steelers.

Steelers Stats

Pittsburgh's Key Players

Offense

• In 10 games played this year, Aaron Rodgers has racked up 1,969 passing yards, while throwing 19 touchdowns (sixth in the NFL) against seven interceptions and completing 66.4% of his passes.
• Jaylen Warren has scored three rushing touchdowns, while totaling 604 rushing yards (4.3 per carry and 60.4 per game).
• Warren has also picked up 219 receiving yards (21.9 per game) on 25 catches (2.5 per game). He's been targeted 28 times and has caught one touchdown pass.
• So far this season, D.K. Metcalf has caught 42 passes for 573 receiving yards with five touchdowns through the air. He has been targeted 70 total times and is averaging 3.8 receptions per game in 11 games played.
• Kenneth Gainwell has 336 rushing yards (second on the Steelers) and three rushing touchdowns, while averaging 30.5 yards per game and 4.7 per attempt (14th in the NFL).
• Gainwell has also caught 42 passes for 234 yards (fourth on the Steelers), with two receiving touchdowns. He's been targeted 48 times and averages 21.3 yards per game.

Defense

• T.J. Watt has intercepted one pass to go with 43 tackles, 9.0 TFL, seven sacks, and seven passes defended in 2025.
• Payton Wilson has one interception on top of 79 tackles, 5.0 TFL, one sack, and two passes defended.
• In the 2025 season, Nick Herbig has 24 tackles, 10.0 TFL, 6.5 sacks, and one interception through 10 games.
• Patrick Queen's stats include 83 tackles, 5.0 TFL, one sack, and four passes defended in 11 games

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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