Bengals vs. Cardinals 2025 Prediction, Odds, Picks - Dec 28

Having lost one straight, the Arizona Cardinals (3-12) will face the Cincinnati Bengals (5-10). The Bengals are solid favorites, expected to win by at least a touchdown (currently -7.5). An over/under of 53.5 points has been established for the matchup.

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Bengals vs. Cardinals Odds & Betting Lines

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Bengals vs. Cardinals Prediction & Pick

• Pick ATS: Cardinals (+7.5)
  
• Pick OU: Under (53.5)
  
• Prediction: Bengals 27 - Cardinals 24

How to Watch Cincinnati vs. Arizona

• Game date: Sunday, December 28, 2025
• Time: 1 p.m. ET
• Venue: Paycor Stadium
• Location: Cincinnati, Ohio
• TV: Watch on FOX
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Bengals vs. Cardinals Recent Matchups

• Cincinnati and Arizona have been evenly matched over their last two meetings, sharing the same 1-1 record.
• Over their last two head-to-head contests, Cincinnati has racked up 57 points, while Arizona has posted 46.

Cincinnati Betting Info

• In 15 Cincinnati games this year, it has seven wins against the spread.
• Cincinnati games this year have hit the over on nine of 15 set point totals (60%).
• The Bengals have won 75% of the time they have played as the moneyline favorite (3-1).
• The Bengals have an implied win probability, based on the moneyline, of 79.2%.

Bengals Stats

Cincinnati's Key Players

Offense

• Chase Brown has put up 846 rushing yards with four touchdowns (56.4 yards per game through 15 games). His 4.3 yards per attempt rank 26th in the NFL.
• Brown has been targeted 79 times in the passing game and has 62 catches (4.1 per game) for 379 yards (25.3 per game) and four TDs.
• Ja'Marr Chase's 1,256 receiving yards this season (fifth in the NFL) have come from 166 targets and 110 receptions (second in the NFL). He's averaging 89.7 receiving yards and 7.9 catches per game, with five receiving touchdowns.
• Joe Flacco has 2,455 passing yards in 11 games this year, averaging 223.2 per game with a 60.3% completion percentage and 15 touchdowns against 10 interceptions.
• He has also rushed for 31 yards (fifth on the Bengals) and added one touchdown on the ground, averaging 2.8 yards per game.
• Tee Higgins has 49 receptions for 720 yards and 10 touchdowns. He's been targeted 84 times in the air attack, and averages 3.8 receptions and 55.4 yards through 13 games played.

Defense

• Over on defense, Jordan Battle has four interceptions (sixth in the NFL) to go with 107 tackles, two TFL, and six passes defended in 2025.
• Demetrius Knight II has picked off two pases and added 98 tackles, four TFL, two sacks, and six passes defended.
• Geno Stone has recorded 97 tackles, four TFL, two sacks, and two interceptions this year. He's third on the Bengals in tackles.
• So far this season, Barrett Carter has 94 tackles, one TFL, and one interception.

Arizona Betting Info

• Arizona has covered the spread in a game six times this year (6-9-0).
• The Cardinals have been underdogs by 7.5 points or more three times this season and covered the spread once.
• This year, nine Arizona games have gone over the point total.
• The Cardinals have entered the game as underdogs 12 times this season and won once.
• The implied probability of a win by the Cardinals based on the moneyline is 25.0%.

Cardinals Stats

Arizona's Key Players

Offense

• Through 12 games played this year, Jacoby Brissett has totaled 2,911 passing yards, while throwing 19 touchdowns against seven interceptions and completing 65.2% of his passes.
• Brissett has also rushed for one touchdown and 149 yards (sixth on the Cardinals).
• Trey McBride has 109 catches (third in the NFL) for 1,098 yards (sixth in the NFL) and 10 receiving touchdowns (third in the NFL). He has been targeted 148 times and averages 7.3 receptions per game in 15 games played.
• Through 15 games played this season, Michael Wilson has 68 catches (4.5 receptions per game on 7.2 targets per game) for 818 yards and five receiving touchdowns.
• Marvin Harrison Jr. has 41 catches for 608 yards and four receiving touchdowns. He averages 3.7 yards per game through 11 games and has been targeted 72 times.

Defense

• In 2025, Josh Sweat has recorded 11 sacks to go with 12 TFL and 27 tackles over 14 games. He ranks ninth in the NFL in sacks.
• Budda Baker has 0.5 sacks to go with two TFL, 111 tackles, and one interception.
• Akeem Davis-Gaither has intercepted one pass on top of 90 tackles, two TFL, and four passes defended in the 2025 season.
• Jalen Thompson's season stats include 81 tackles, two TFL, and one sack through 13 games. He is third on the Cardinals in tackles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cincinnati Bengals

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