Timberwolves vs. Trail Blazers Prediction, Odds, Picks - Oct. 22

The Minnesota Timberwolves take the court against the Portland Trail Blazers on October 22, 2025 in the opening contest of the 2025-26 season for both teams. Wednesday's game between the Timberwolves and the Trail Blazers sees the Timberwolves as 4.5-point favorites. The game has a point total of 221.5.

Here is everything you need to know to know about the Timberwolves-Trail Blazers game, from the point spread, moneyline, total Over/Under and expert picks, as well as TV channel and streaming information.

Timberwolves vs. Trail Blazers Game Information, TV Channel & Odds

• When: Wednesday, October 22, 2025 at 10 p.m. ET
• Where: Moda Center in Portland, Oregon
• TV: KUNP and FDSN
• Live Boxscore: FOX Sports

Timberwolves vs. Trail Blazers Prediction

ATS Pick: Timberwolves (- 4.5)
O/U Pick: Over (221.5)
Score Prediction: Timberwolves 115 - Trail Blazers 109

Timberwolves vs. Trail Blazers Betting Insights

• The Timberwolves' 82 games last season went over this contest's total of 221.5 points 44 times.
• The Trail Blazers combined with their opponent to score more than 221.5 points in 47 of 82 games last season.
• The teams combined to score 225.2 points per game last season, 3.7 more points than the over/under for this matchup.
• Opponents of these teams averaged 223.2 combined points per game last year, 1.7 more than the over/under for this matchup.
• Timberwolves matchups last season had an average point total of 221.6, 0.1 more points than this game's over/under.
• The Trail Blazers had a 224.1-point average over/under in their contests last year, 2.6 more points than the point total for this game.

Timberwolves Recent Trends

• Minnesota put together a 39-42-1 record against the spread last season.
• Minnesota was 19-22 ATS last season when playing as at least a 4.5-point favorite.
• Last season, the combined scoring went over the point total 45 times in Minnesota's games.
• Last year, the Timberwolves scored 114.3 points per game, just 0.4 more points than the 113.9 the Trail Blazers gave up.
• Minnesota had a 27-17 record against the spread and a 33-11 record overall last season when putting up more than 113.9 points.
• Last season, the Timberwolves had a 46.8% shooting percentage from the field, which was 0.3% lower than the 47.1% of shots the Trail Blazers' opponents knocked down.
• Against the spread last season, the Timberwolves fared worse at home, covering 17 times in 41 home games, and 22 times in 41 road games.
• When it came to over/unders, Minnesota hit the over more often at home last season, as it went over the total 25 times in 41 opportunities (61%). On the road, it hit the over 20 times in 41 opportunities (48.8%).
• As a moneyline favorite, the Timberwolves won a higher percentage of their games when playing at home (.639) compared to road games (.630) last year.

Timberwolves Recent Stats

Timberwolves Leaders

• Anthony Edwards posted 27.6 points, 5.7 rebounds and 4.5 assists last year. He also drained 44.7% of his shots from the floor and 39.5% from beyond the arc, with 4.1 triples per game (second in NBA).
• Per game, Julius Randle put up 18.7 points, 7.1 boards and 4.7 assists. He also put up 0.7 steals and 0.2 blocks.
• Rudy Gobert's numbers last season were 12.0 points, 10.9 boards and 1.8 assists per game. He drained 66.9% of his shots from the floor (third in league).
• Naz Reid averaged 14.2 points, 6.0 rebounds and 2.3 assists per contest, plus 0.7 steals and 0.9 blocks.
• Last season, Jaden McDaniels posted 12.2 points, 5.7 boards and 2.0 assists. He made 47.7% of his shots from the floor and 33.0% from 3-point range, with 1.2 triples per game.

Timberwolves Player Props

Trail Blazers Recent Trends

• The Trail Blazers put together a 46-35-1 record against the spread last season.
• As a 4.5-point underdog or more, Portland went 29-23-1 against the spread last year.
• Trail Blazers games went over the point total 40 out of 82 times last season.
• The Trail Blazers scored an average of 110.9 points per game last year, only 1.6 more points than the 109.3 the Timberwolves gave up to opponents.
• When it scored more than 109.3 points last season, Portland went 33-12 against the spread and 27-18 overall.
• The Trail Blazers shot 45.0% from the field, 1.0% lower than the 46.0% the Timberwolves' opponents shot last season.
• The Trail Blazers were better against the spread at home (24-17-0) than away (22-18-1) last year.
• In terms of the over/under, Portland's games went over 21 of 41 times at home (51.2%) last season, and 19 of 41 away (46.3%).
• The Trail Blazers, as moneyline favorites, won a lower percentage of games at home (6-2) than away (4-1) last year.

Trail Blazers Recent Stats

Trail Blazers Leaders

• Damian Lillard scored 24.9 points and distributed 7.1 assists per game last season.
• Donovan Clingan hauled in an average of 7.9 boards in each contest while scoring 6.5 points per game last season.
• Lillard knocked down shots from beyond the arc at a clip of 3.4 per contest a season ago.
• Toumani Camara and Clingan were defensive standouts last season, with Camara averaging 1.5 steals per game and Clingan collecting 1.6 blocks per contest.

Trail Blazers Player Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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National Basketball Association

Portland Trail Blazers

Minnesota Timberwolves