Pistons vs. Bulls Prediction, Odds, Picks - Oct. 22

The Detroit Pistons square off against the Chicago Bulls on October 22, 2025 in the first game of the 2025-26 season for both teams. Detroit is a small 2.5-point favorite against Chicago when the Pistons face off with the Bulls on Wednesday. The over/under is 236.5 points for the game.

Here's everything you need to know to know about the Pistons-Bulls game, from the point spread, moneyline, total Over/Under and expert picks, as well as TV channel and streaming information.

Pistons vs. Bulls Game Information, TV Channel & Odds

• When: Wednesday, October 22, 2025 at 8 p.m. ET
• Where: United Center in Chicago, Illinois
• TV: CHSN and FDSDET
• Live Boxscore: FOX Sports

Pistons vs. Bulls Prediction

ATS Pick: Bulls (+ 2.5)
O/U Pick: Under (236.5)
Score Prediction: Pistons 117 - Bulls 116

Pistons vs. Bulls Betting Insights

• In 30 games last season, the Pistons and their opponents went over 236.5 combined points.
• The Bulls played 43 games last season that finished with a combined score higher than 236.5 points.
• The teams combined to score 233.3 points per game last season, 3.2 fewer points than this matchup's total.
• Opponents of these two teams combined to score 233 points per game last year, 3.5 fewer points than this matchup's total.
• Pistons matchups last season had an average point total of 226.2, 10.3 fewer points than this game's over/under.
• The average over/under for Bulls matchups last year was 235.5, 1.0 more points than this game's total.

Pistons Recent Trends

• Detroit covered 42 times in 82 matchups with a spread last season.
• Detroit had an ATS record of 19-15 when playing as at least a 2.5-point favorite last season.
• Detroit and its opponent combined to hit the over 42 out of 82 times last season.
• Last year, the Pistons recorded only 3.9 fewer points per game (115.5) than the Bulls allowed (119.4).
• When Detroit totaled more than 119.4 points last season, it went 20-8-1 against the spread and 21-8 overall.
• The Pistons made 47.6% of their shots from the field last season, which was 0.9 percentage points higher than the Bulls allowed to their opponents (46.7%).
• At home last season, the Pistons owned a worse record against the spread (19-20-2) compared to their ATS record on the road (23-16-2).
• Detroit eclipsed the over/under in a lower percentage of home games (48.8%) than road games (53.7%) last year.
• The Pistons played worse as a moneyline favorite at home last year, posting a home record of 14-9, compared to going 12-5 in road games.

Pistons Recent Stats

Pistons Leaders

• Cade Cunningham's numbers last season were 26.1 points, 6.1 boards and 9.1 assists per game. He also sank 46.9% of his shots from the floor and 35.6% from beyond the arc, with an average of 2.1 triples.
• Per game, Jalen Duren recorded 11.8 points, 10.3 boards and 2.7 assists. He also averaged 0.7 steals and 1.1 blocks.
• Tobias Harris' stats last season included 13.7 points, 5.9 rebounds and 2.2 assists per game. He made 47.7% of his shots from the floor and 34.5% from beyond the arc, with an average of 1.2 triples.
• Caris LeVert averaged 12.1 points, 3.2 rebounds and 3.4 assists. He made 46.7% of his shots from the field and 37.3% from 3-point range, with 1.7 treys per contest.
• Last season, Ausar Thompson recorded 10.1 points, 5.1 rebounds and 2.3 assists. He made 53.5% of his shots from the floor.

Pistons Player Props

Bulls Recent Trends

• The Bulls compiled a 43-36-3 record against the spread last year.
• Chicago had an ATS record of 28-24-2 as an underdog of 2.5 points or greater last season.
• A total of 44 of the Bulls' games last season went over the point total.
• The Bulls scored just 4.2 more points per game last year (117.8) than the Pistons gave up to opponents (113.6).
• Chicago put together a 37-13-3 ATS record and a 35-18 overall record last season in games it scored more than 113.6 points.
• The Bulls' 47.0% shooting percentage from the field last season was 0.9 percentage points higher than the Pistons allowed to their opponents (46.1%).
• In 2024-25 against the spread, the Bulls had a lower winning percentage at home (.512, 21-19-1 record) than on the road (.537, 22-17-2).
• Looking at the over/under, Chicago's games finished over 21 of 41 times at home (51.2%) and 23 of 41 on the road (56.1%) last season.
• The Bulls, when moneyline favorites, won a lower percentage of games at home (8-7) than away (6-2) last season.

Bulls Recent Stats

Bulls Leaders

• Coby White averaged 20.4 points per contest to go with 3.7 rebounds and 4.5 assists per game last season.
• Nikola Vucevic pulled down 10.1 rebounds per game, while Josh Giddey dished out 7.2 assists per contest.
• White hit an average of 2.9 shots per game from beyond the arc a season ago.
• Giddey averaged 1.2 takeaways per game, while Matas Buzelis compiled 0.9 rejections per contest.

Bulls Player Props

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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