Yankees vs. Orioles Prediction, Odds, Picks - September 27

Cam Schlittler is set to start for the New York Yankees on Saturday against Coby Mayo and the Baltimore Orioles. First pitch is at 1:05 p.m. ET at Yankee Stadium. The favored Yankees have -234 moneyline odds against the underdog Orioles, who are listed at +192. New York (-1.5) is favored on the run line. The over/under is 9 runs for this contest (with -104 odds to go over and -116 odds to go under).

Here is everything you need from a betting perspective on the Yankees-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Rays vs. Orioles Highlights | MLB on FOX

Check out the best moments between the Tampa Bay Rays and Baltimore Orioles.

Yankees vs. Orioles Game Information & Odds

• When: Saturday, September 27, 2025 at 1:05 p.m. ET
• Where: Yankee Stadium in The Bronx, New York
• How to watch on TV: YES and MASN

Yankees vs. Orioles Prediction

• Score Prediction: Yankees 5, Orioles 4
• Total Prediction: Over 9 runs
• Win Probabilities: Yankees 58%, Orioles 42%

Yankees vs. Orioles Betting Insights

• This season, the Yankees have won 82 out of the 137 games, or 59.9%, in which they've been favored.
• New York has a record of 12-6, a 66.7% win rate, when favored by -234 or more by oddsmakers this season.
• The oddsmakers' moneyline implies a 70.1% chance of a victory for the Yankees.
• The Orioles have won in 42, or 45.7%, of the 92 contests they have been named as odds-on underdogs this year.
• This season, Baltimore has come away with a win two times in three chances when named as an underdog of at least +192 or longer on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Orioles have a 34.2% chance of pulling out a win.

Yankees Recent Betting Performance

• The Yankees have a 9-1 record across the 10 games they were a moneyline favorite in their last 10 matchups.
• In their last 10 outings (all had set totals), the Yankees combined with their opponents to go over the total four times.
• The Yankees have gone 7-3-0 against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Aaron Judge paces the Yankees with 52 home runs and 111 runs batted in, while racking up a team-best batting average of .330.
• In all of MLB, Judge ranks fourth in home runs and fifth in RBI.
• Judge brings a hitting streak of three games into this game. In his last five games he is batting .375 with a double, three home runs, eight walks and six RBIs.
• Cody Bellinger has 25 doubles, five triples, 29 home runs and 57 walks while hitting .272.
• Bellinger is 33rd in homers in MLB, and 17th in RBI.
• Bellinger carries a three-game streak with at least one hit into this contest. In his last five games he is batting .278 with six walks.
• Trent Grisham is batting .238 with nine doubles, a triple, 34 home runs and 80 walks.
• Grisham will look to build on his three-game hitting in this matchup. In his last five games he is hitting .176 with a home run, six walks and two RBIs.
• Jazz Chisholm is hitting .244 with 15 doubles, a triple, 31 home runs and 58 walks.

Yankees Team Props

Orioles Recent Betting Performance

• The Orioles have played as underdogs in eight of their past 10 games and won four of those contests.
• In their last 10 games with a total, the Orioles and their opponents have failed to hit the over seven times.
• The Orioles have a record of 4-6-0 ATS over their last 10 games.

Orioles Recent Stats

Orioles Player Insights

• The Orioles are led in runs batted in by Gunnar Henderson with a mark of 67, he also leads the team in hitting, posting an average of .273.
• In all of MLB, Henderson ranks 123rd in homers and 95th in RBI.
• Jackson Holliday's 17 home runs lead his team.
• Holliday is 111th among all hitters in the majors in home runs, and 141st in RBI.
• Jordan Westburg has 10 doubles, a triple, 16 home runs and 17 walks while batting .266.
• Adley Rutschman has 16 doubles, two triples, nine home runs and 39 walks while batting .223.

Orioles Team Props

Rays vs. Orioles Highlights | MLB on FOX

Check out the best moments between the Tampa Bay Rays and Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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