Yankees vs. Astros Prediction, Odds, Picks - September 3

The New York Yankees and Jazz Chisholm will hit the field against the Houston Astros and Jeremy Pena on Wednesday at 8:10 p.m. ET, in the second of a three-game series at Daikin Park. The Yankees are -133 moneyline favorites for this matchup with the Astros (+112). New York is the favorite on the run line (-1.5). A 9-run over/under is set in the game.

Here is everything you need from a betting perspective on the Yankees-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Yankees vs. Astros Game Information & Odds

• When: Wednesday, September 3, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: MLB Network, SCHN, and Amazon Prime Video

Yankees vs. Astros Prediction

• Score Prediction: Yankees 5, Astros 4
• Total Prediction: Under 9 runs
• Win Probabilities: Yankees 51%, Astros 49%

Yankees vs. Astros Betting Insights

• The Yankees have been favorites in 116 games this season and won 67 (57.8%) of those contests.
• New York has a record of 56-39, a 58.9% win rate, when favored by -133 or more by bookmakers this season.
• Sportsbooks have implied with the moneyline set for this matchup that the Yankees have a 57.1% chance to win.
• The Astros have won in 26, or 57.8%, of the 45 contests they have been named as odds-on underdogs this year.
• Houston has a win-loss record of 14-11 when favored by +112 or worse by bookmakers this year.
• Oddsmakers have implied with the moneyline set for this matchup that the Astros have a 47.2% chance of pulling out a win.

Yankees Recent Betting Performance

• The Yankees went 8-1 over the nine games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings, the Yankees and their opponents combined to hit the over on the run total six times (all 10 games had set totals).
• The Yankees are 8-2-0 against the spread over their past 10 games.

Yankees Recent Stats

Yankees Player Insights

• Aaron Judge's 43 round-trippers and 97 RBI both lead the Yankees, on top of his team-high .325 average.
• Among all hitters in MLB, Judge ranks fourth in home runs and seventh in RBI.
• Judge has collected a hit in three straight games. During his last five outings he is hitting .368 with a double, two home runs, six walks and two RBIs.
• Cody Bellinger is batting .279 with 23 doubles, five triples, 26 home runs and 42 walks.
• Bellinger ranks 29th in homers in baseball, and 20th in RBI.
• Bellinger enters this game looking for his fourth game in a row with a hit. During his last five outings he is batting .273 with two doubles, a home run, two walks and four RBIs.
• Trent Grisham is hitting .248 with nine doubles, a triple, 29 home runs and 67 walks.
• Chisholm is hitting .243 with 13 doubles, a triple, 28 home runs and 54 walks.

Yankees Team Props

Astros Recent Betting Performance

• In three games as underdogs over the last 10 matchups, the Astros have a record of 1-2.
• In their last 10 games with a total, the Astros and their opponents have combined to hit the over two times.
• Over their last 10 games, the Astros are 5-5-0 against the spread.

Astros Recent Stats

Astros Player Insights

• Jose Altuve leads the Astros with 24 long balls.
• Altuve's home run total puts him 39th in MLB, and he ranks 63rd in RBI.
• Pena has a club-high .304 batting average.
• Pena is 126th in home runs and 135th in RBI among all major league hitters this season.
• Yainer Diaz has 18 doubles, a triple, 18 home runs and 19 walks while hitting .253.
• Christian Walker has driven in a team-leading 74 runs batted in.

Astros Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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