Tigers vs. White Sox Prediction, Odds, Picks - September 5

The Detroit Tigers and Wenceel Perez will take the field against the Chicago White Sox and Kyle Teel on Friday at 6:40 p.m. ET, at Comerica Park. The Tigers are favored in this one, at -197, while the underdog White Sox have +163 odds to win. Detroit is a 1.5-run favorite (at +105 odds). An 8.5-run total is listed for this game.

Here is everything you need to know from a betting perspective on the Tigers-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Mets vs. Tigers Highlights | MLB on FOX

Check out the best moments between the New York Mets and the Detroit Tigers.

Tigers vs. White Sox Game Information & Odds

• When: Friday, September 5, 2025 at 6:40 p.m. ET
• Where: Comerica Park in Detroit, Michigan
• How to watch on TV: FDSDET and CHSN

Tigers vs. White Sox Prediction

• Score Prediction: Tigers 6, White Sox 4
• Total Prediction: Over 8.5 runs
• Win Probabilities: Tigers 56%, White Sox 44%

Tigers vs. White Sox Betting Insights

• This season, the Tigers have been favored 98 times and won 61, or 62.2%, of those games.
• Detroit has a record of 18-6, a 75% win rate, when favored by -197 or more by oddsmakers this season.
• Bookmakers have implied with the moneyline set for this matchup that the Tigers have a 66.3% chance to win.
• The White Sox have been chosen as underdogs in 139 games this year and have walked away with the win 52 times (37.4%) in those games.
• Chicago has a win-loss record of 15-38 when favored by +163 or worse by bookmakers this year.
• The White Sox have an implied victory probability of 38% according to the moneyline set for this matchup.

Tigers Recent Betting Performance

• The Tigers were the moneyline favorite for six of their last 10 games, and they went 1-5 in those matchups.
• In their last 10 matchups (all had set totals), the Tigers combined with their opponents to go over the total five times.
• The Tigers are 3-7-0 against the spread over their past 10 games.

Tigers Recent Stats

Tigers Player Insights

• Riley Greene is the bat to watch in the Tigers lineup, leading the team in batting average (.269), home runs (32), and RBI (103).
• Of all hitters in MLB, Greene's home run total ranks him 10th, and his RBI tally puts him fifth.
• Gleyber Torres is batting .261 with 19 doubles, 14 home runs and 73 walks.
• Torres ranks 131st in home runs and 81st in RBI among all batters in baseball.
• Spencer Torkelson has 25 doubles, a triple, 28 home runs and 62 walks while batting .238.
• Torkelson is on a three-game hitting streak entering this contest. In his last five games he is batting .222 with two walks and an RBI.
• Zach McKinstry is batting .267 with 19 doubles, 11 triples, 11 home runs and 45 walks.
• McKinstry takes a four-game streak with at least one hit into this one. In his last five games he is batting .429 with a double, a triple, two walks and three RBIs.

Tigers Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and have gone 5-5 in those contests.
• When it comes to hitting the over, the White Sox and their opponents are 7-3-0 in their last 10 games with a total.
• The White Sox have won six of their last 10 games against the spread.

White Sox Recent Stats

White Sox Player Insights

• Andrew Benintendi is hitting .244 with 15 doubles, two triples, 17 home runs and 35 walks, while getting on base at a rate of .307.
• In all of MLB, Benintendi ranks 92nd in homers and 111th in RBI.
• Lenyn Sosa has hit 19 home runs with 62 runs batted in while hitting .263. Those numbers are pace the clubhouse.
• Among all major league batters, Sosa ranks 70th in home runs and 85th in RBI.
• Chase Meidroth is hitting .258 with 15 doubles, four home runs and 38 walks.
• Mike Tauchman is batting .271 with 15 doubles, a triple, eight home runs and 40 walks.

White Sox Team Props

Mets vs. Tigers Highlights | MLB on FOX

Check out the best moments between the New York Mets and the Detroit Tigers.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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