Red Sox vs. Orioles Prediction, Odds, Picks - May 23

The Boston Red Sox and Carlos Narvaez will hit the field against the Baltimore Orioles and Jackson Holliday on Friday at 1:35 p.m. ET, in the first game of a four-game series at Fenway Park. The Red Sox are the favorite in this one, at -134, while the underdog Orioles have +112 odds to win. Boston is the run-line favorite (-1.5). The over/under is 9.5 runs for this matchup (with -114 odds to go over and -106 odds on the under).

Check out everything you need from a betting perspective on the Red Sox-Orioles game, regarding the run line, moneyline and total, plus expert picks.

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Red Sox vs. Orioles Game Information & Odds

• When: Friday, May 23, 2025 at 1:35 p.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: MLB Network, NESN, and MASN

Red Sox vs. Orioles Prediction

• Score Prediction: Red Sox 5, Orioles 4
• Total Prediction: Under 9.5 runs
• Win Probabilities: Red Sox 57%, Orioles 43%

Red Sox vs. Orioles Betting Insights

• The Red Sox have been favorites in 35 games this season and won 18 (51.4%) of those contests.
• This season Boston has won seven of its 15 games, or 46.7%, when favored by at least -134 on the moneyline.
• The Red Sox have a 57.3% chance to win this game based on the implied probability of the moneyline.
• The Orioles have won in seven, or 35%, of the 20 contests they have been named as odds-on underdogs this year.
• This season, Baltimore has come away with a win one time in eight chances when named as an underdog of at least +112 or worse on the moneyline.
• The Orioles have an implied victory probability of 47.2% according to the moneyline set for this matchup.

Red Sox Recent Betting Performance

• The Red Sox have a 1-3 record from the four games they were moneyline favorites over their last 10 matchups.
• In their last 10 matchups -- all had a set run total -- the Red Sox and their opponents combined to hit the over on the total five times.
• The Red Sox's ATS record is 5-5-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Alex Bregman's .297 average and 11 homers both put him atop the Red Sox leaderboard this season.
• Of all hitters in baseball, Bregman's home run total places him 17th, and his RBI tally ranks him 12th.
• Rafael Devers has collected 39 runs batted in to lead his team.
• Devers ranks 21st in homers and fourth in RBI in the major leagues.
• Devers carries a two-game streak with at least one hit into this contest. In his last five games he is batting .438 with two doubles, three home runs, five walks and seven RBIs.
• Wilyer Abreu has collected a team-best 11 home runs.
• Jarren Duran has 11 doubles, six triples, three home runs and 13 walks while hitting .265.

Red Sox Team Props

Orioles Recent Betting Performance

• In three games as underdogs over the last 10 matchups, the Orioles have a record of 1-2.
• The Orioles and their opponents have combined to hit the over seven times in their last 10 games with a total.
• Over their last 10 games, the Orioles are 2-8-0 against the spread.

Orioles Recent Stats

Orioles Player Insights

• Cedric Mullins has a team-high 10 home runs and has driven in 31 runs.
• Mullins' home run total places him 21st in MLB, and he is 23rd in RBI.
• Mullins carries a four-game hitting streak into this matchup. In his last five games he is batting .316 with two doubles, two home runs, a walk and six RBIs.
• Ryan O'Hearn has a club-high .306 batting average.
• O'Hearn is 70th in homers and 168th in RBI among all batters in MLB.
• Adley Rutschman has seven doubles, a triple, five home runs and 19 walks while hitting .213.
• Holliday is batting .268 with four doubles, two triples, six home runs and 10 walks.

Orioles Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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