Red Sox vs. Guardians Prediction, Odds, Picks - September 2

Nolan Jones and Roman Anthony take the field when the Cleveland Guardians and Boston Red Sox meet on Tuesday at Fenway Park. The Red Sox are favored in this one, at -271, while the underdog Guardians have +218 odds to play spoiler. Boston is a 1.5-run favorite (at -124 odds). The total is 7.5 runs for this game (with -115 odds on the over and -105 odds on the under).

Take a look at everything you need from a betting perspective on the Red Sox-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Red Sox Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Boston Red Sox.

Red Sox vs. Guardians Game Information & Odds

• When: Tuesday, September 2, 2025 at 6:45 p.m. ET
• Where: Fenway Park in Boston, Massachusetts
• How to watch on TV: NESN and CLEG

Red Sox vs. Guardians Prediction

• Score Prediction: Red Sox 4, Guardians 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Red Sox 59%, Guardians 41%

Red Sox vs. Guardians Betting Insights

• The Red Sox have won 51, or 60%, of the 85 games they've played as favorites this season.
• Boston has entered five games this season favored by -271 or more and is 4-1 in those contests.
• The implied probability of a win from the Red Sox, based on the moneyline, is 73%.
• The Guardians have been underdogs in 76 games this season and have come away with the win 33 times (43.4%) in those contests.
• Cleveland has been listed as an underdog of +218 or more on two occasions this season and lost both games.
• Sportsbooks have implied with the moneyline set for this matchup that the Guardians have a 31.4% chance of pulling out a win.

Red Sox Recent Betting Performance

• The Red Sox played as the moneyline favorite for nine of their last 10 games, and finished 7-2 in those matchups.
• Over their last 10 outings (all 10 of them had set totals), the Red Sox and their opponents combined to go over the run total four times.
• The Red Sox's record against the spread is 4-6-0 over their past 10 games.

Red Sox Recent Stats

Red Sox Player Insights

• Jarren Duran has a team-best batting average of .260.
• Among all hitters in the majors, Duran's home run total places him 125th, and his RBI tally puts him 34th.
• Trevor Story's 23 home runs, 86 RBI and .260 batting average are all team-highs.
• Story is 41st in homers and 16th in RBI in the majors.
• Ceddanne Rafaela has 29 doubles, three triples, 15 home runs and 22 walks while hitting .248.
• Alex Bregman is hitting .286 with 25 doubles, 16 home runs and 39 walks.
• Bregman has recorded at least one hit in two games in a row. During his last five outings he is hitting .095 with a double.

Red Sox Team Props

Guardians Recent Betting Performance

• In eight games as underdogs over the last 10 matchups, the Guardians have a record of 3-5.
• In their last 10 games with a total, the Guardians and their opponents have failed to hit the over six times.
• The Guardians have a record of 5-5-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the lineup with a batting average of .280, while leading the Guardians in home runs, with 26 and runs batted in with 68.
• Among all batters in the majors, Ramirez's home run total ranks 25th and his RBI tally is 61st.
• Steven Kwan has 24 doubles, a triple, 10 home runs and 45 walks while batting .274.
• Kwan is currently 182nd in homers and 179th in RBI in the big leagues.
• Kyle Manzardo is batting .233 with 14 doubles, two triples, 24 home runs and 41 walks.
• Angel Martinez is batting .225 with 21 doubles, a triple, 10 home runs and 16 walks.

Guardians Team Props

Guardians vs. Red Sox Highlights | MLB on FOX

Check out the best moments between the Cleveland Guardians and the Boston Red Sox.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Boston Red Sox

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