Phillies vs. Guardians Prediction, Odds, Picks - May 10

Kyle Schwarber and the Philadelphia Phillies head into the second of a three-game series against Daniel Schneemann and the Cleveland Guardians at Progressive Field, Saturday at 6:10 p.m. ET. Bookmakers list the Phillies as -132 moneyline favorites, while giving the underdog Guardians +112 moneyline odds to win. Philadelphia (-1.5) is favored on the run line. The total is 8 runs for this matchup.

Take a look at everything you need to know from a betting perspective on the Phillies-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Phillies vs. Guardians Highlights | MLB on FOX

Check out the best highlights between the Philadelphia Phillies and Cleveland Guardians.

Phillies vs. Guardians Game Information & Odds

• When: Saturday, May 10, 2025 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and NBCS-PH

Phillies vs. Guardians Prediction

• Score Prediction: Guardians 5, Phillies 4
• Total Prediction: Over 8 runs
• Win Probabilities: Phillies 51%, Guardians 49%

Phillies vs. Guardians Betting Insights

• The Phillies have been favorites in 30 games this season and won 18 (60%) of those contests.
• Philadelphia has a record of 16-7, a 69.6% win rate, when favored by -132 or more by oddsmakers this season.
• The bookmakers' moneyline implies a 56.9% chance of a victory for the Phillies.
• The Guardians have been victorious in 11, or 50%, of the 22 contests they have been chosen as underdogs in this season.
• Cleveland has a win-loss record of 4-7 when favored by +112 or worse by oddsmakers this year.
• The moneyline set for this matchup implies the Guardians have a 47.2% chance of walking away with the win.

Phillies Recent Betting Performance

• The Phillies have a 7-3 record from the 10 games they were moneyline favorites over their last 10 matchups.
• In their last 10 matchups -- all had a set run total -- the Phillies and their opponents combined to go over the total five times.
• The Phillies' ATS record is 4-6-0 over their past 10 games.

Phillies Recent Stats

Phillies Player Insights

• Schwarber has racked up a team-high 12 home runs and 28 runs batted in.
• Of all hitters in the majors, Schwarber's home run total ranks him first, and his RBI tally puts him 11th.
• Bryce Harper is hitting .229 with seven doubles, six home runs and 27 walks.
• Among all major league batters, Harper is 50th in homers and 50th in RBI.
• Trea Turner paces the Phillies with a .315 batting average.
• Turner will look to build on his eight-game hitting in this game. During his last 10 outings he is batting .442 with three doubles, a home run, two walks and four RBIs.
• Bryson Stott is batting .271 with five doubles, two triples, three home runs and 13 walks.

Phillies Team Props

Guardians Recent Betting Performance

• In five games as underdogs over the last 10 matchups, the Guardians have a record of 4-1.
• In their last 10 games with a total, the Guardians and their opponents have failed to hit the over five times.
• The Guardians have five wins against the spread in their last 10 chances.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan leads the Guardians with a .333 batting average.
• In all of MLB, Kwan ranks 104th in homers and 90th in RBI.
• Kwan carries a seven-game hitting streak into this matchup. During his last 10 games he is hitting .300 with two doubles, six walks and two RBIs.
• Jose Ramirez has seven doubles, six home runs and 12 walks while hitting .278.
• Ramirez is 50th overall in home runs and 78th in RBI this season.
• Kyle Manzardo has been a significant run producer for the Guardians with nine home runs and 22 runs batted in.
• Carlos Santana is batting .229 with three doubles, four home runs and 16 walks.

Guardians Team Props

Phillies vs. Guardians Highlights | MLB on FOX

Check out the best highlights between the Philadelphia Phillies and Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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