Orioles vs. Nationals Prediction, Odds, Picks - April 22

The Baltimore Orioles and Washington Nationals will meet on Tuesday at Nationals Park, at 6:45 p.m. ET, with Cedric Mullins and James Wood -- two hot hitters -- expected to step up at the plate. Bookmakers list the Orioles as -134 favorites on the moneyline, while giving the underdog Nationals +114 moneyline odds to win. Baltimore is the favorite on the run line (-1.5 with +119 odds). A 9-run over/under has been set in this game.

Check out everything you need to know from a betting perspective on the Orioles-Nationals game, regarding the run line, moneyline and total, plus expert picks.

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Orioles vs. Nationals Game Information & Odds

• When: Tuesday, April 22, 2025 at 6:45 p.m. ET
• Where: Nationals Park in Washington D.C.
• How to watch on TV: MASN and MASN2

Orioles vs. Nationals Prediction

• Score Prediction: Nationals 5, Orioles 4
• Total Prediction: Under 9 runs
• Win Probabilities: Orioles 52%, Nationals 48%

Orioles vs. Nationals Betting Insights

• This season, the Orioles have been favored 12 times and won five, or 41.7%, of those games.
• Baltimore has entered six games this season favored by -134 or more and is 2-4 in those contests.
• The Orioles have a 57.3% chance to win this game based on the implied probability of the moneyline.
• The Nationals have been underdogs in 17 games this season and have come away with the win seven times (41.2%) in those contests.
• Washington has a mark of 4-9 in contests where sportsbooks favor it by +114 or worse on the moneyline.
• The moneyline set for this matchup implies the Nationals have a 46.7% chance of coming away with a victory in the contest.

Orioles Recent Betting Performance

• The Orioles have a 4-5 record from the nine games they were moneyline favorites over their last 10 matchups.
• Over their last 10 outings -- all had a set run total -- the Orioles and their opponents combined to hit the over on the total six times.
• The Orioles' record against the spread is 3-7-0 over their past 10 games.

Orioles Recent Stats

Orioles Player Insights

• Mullins has a team-best batting average of .284, while leading the Orioles in home runs (six) and runs batted in (19).
• In all of the majors, Mullins ranks 14th in homers and seventh in RBI.
• Mullins carries a three-game hitting streak into this matchup. During his last five outings he is batting .235 with a double, two home runs, five walks and two RBI.
• Adley Rutschman is hitting .208 with two doubles, four home runs and 10 walks.
• Rutschman ranks 43rd in home runs and 161st in RBI on the year.
• Ryan O'Hearn is batting .296 with three doubles, three home runs and six walks.
• Heston Kjerstad has two doubles, three home runs and a walk while hitting .261.

Orioles Team Props

Nationals Recent Betting Performance

• In six games over the last 10 matchups when set as underdogs by bookmakers, the Nationals had a record of 2-4.
• In their last 10 games with a total, the Nationals and their opponents have failed to hit the over five times.
• The Nationals have four wins against the spread in their last 10 chances.

Nationals Recent Stats

Nationals Player Insights

• Wood has put up a team-high seven home runs and has driven in 17 runs.
• Wood's home run total places him fifth in the majors, and he is 14th in RBI.
• Keibert Ruiz's .306 batting average is a team-high mark.
• Among all major league hitters, Ruiz ranks 118th in home runs and 72nd in RBI.
• Nate Lowe has collected a team-high 17 runs batted in.
• Alex Call is batting .293 with two doubles, a triple and 10 walks.

Nationals Team Props

Reds vs. Orioles Highlights | MLB on FOX

Check out the best moments between the Cincinnati Reds and the Baltimore Orioles.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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