Guardians vs. White Sox Prediction, Odds, Picks - September 14

Jose Ramirez and Miguel Vargas are the hottest hitters on the Cleveland Guardians and Chicago White Sox, who meet on Sunday at Progressive Field, at 1:40 p.m. ET. The favored Guardians have -163 moneyline odds to win against the underdog White Sox, who are listed at +136. Cleveland (-1.5) is the favorite on the run line. The total is 8 runs for the game.

Here is everything you need from a betting perspective on the Guardians-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. White Sox Game Information & Odds

• When: Sunday, September 14, 2025 at 1:40 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and CHSN

Guardians vs. White Sox Prediction

• Score Prediction: Guardians 5, White Sox 4
• Total Prediction: Over 8 runs
• Win Probabilities: Guardians 54%, White Sox 46%

Guardians vs. White Sox Betting Insights

• The Guardians have entered the game as favorites 63 times this season and won 39, or 61.9%, of those games.
• Cleveland has entered 10 games this season favored by -163 or more and is 8-2 in those contests.
• The oddsmakers' moneyline implies a 62% chance of a victory for the Guardians.
• The White Sox have been victorious in 56, or 38.1%, of the 147 contests they have been chosen as underdogs in this season.
• This season, Chicago has been victorious 31 times in 92 chances when named as an underdog of at least +136 or longer on the moneyline.
• The White Sox have an implied victory probability of 42.4% according to the moneyline set by oddsmakers for this matchup.

Guardians Recent Betting Performance

• The Guardians went 5-1 across the six games they were a moneyline favorite in their last 10 matchups.
• In their last 10 matchups -- all had a set run total -- the Guardians and their opponents combined to hit the over on the total two times.
• The Guardians' record against the spread is 8-2-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Ramirez leads the Guardians in home runs (28), runs batted in (77) and has a team-best batting average of .280.
• Including all MLB hitters, Ramirez ranks 22nd in batting average, 32nd in on-base percentage, and 18th in slugging.
• Steven Kwan is batting .275 with 26 doubles, a triple, 10 home runs and 51 walks.
• Kwan ranks 195th in homers and 171st in RBI in the bigs.
• Kyle Manzardo is batting .239 with 15 doubles, two triples, 26 home runs and 46 walks.
• Angel Martinez is hitting .226 with 21 doubles, a triple, 11 home runs and 19 walks.

Guardians Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won six of those contests.
• In their last 10 games with a total, the White Sox and their opponents have combined to hit the over five times.
• The White Sox are 7-3-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Vargas is hitting .229 with 30 doubles, two triples, 14 home runs and 50 walks, while getting on base at a rate of .311.
• Among all hitters in MLB, Vargas ranks 141st in home runs and 141st in RBI.
• Andrew Benintendi has 16 doubles, two triples, 19 home runs and 37 walks while batting .243.
• Benintendi is 79th overall in home runs and 106th in RBI this season.
• Lenyn Sosa leads the White Sox in long balls (20), runs batted in (68) and has posted a team-best batting average of .263.
• Chase Meidroth is hitting .269 with 15 doubles, four home runs and 43 walks.

White Sox Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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