Guardians vs. Twins Prediction, Odds, Picks - April 29

Jose Ramirez and the Cleveland Guardians take the field against Byron Buxton and the Minnesota Twins at Progressive Field on Tuesday, at 6:10 p.m. ET. The favored Guardians have -132 moneyline odds to win against the underdog Twins, who are listed at +111. Cleveland is a 1.5-run favorite (at +155 odds). The over/under is 8 runs for this game (with -115 odds to go over and -105 odds on the under).

Check out everything you need to know from a betting perspective on the Guardians-Twins game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Minnesota Twins and the Cleveland Guardians.

Guardians vs. Twins Game Information & Odds

• When: Tuesday, April 29, 2025 at 6:10 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: CLEG and MNNT

Guardians vs. Twins Prediction

• Score Prediction: Twins 5, Guardians 4
• Total Prediction: Over 8 runs
• Win Probabilities: Guardians 51%, Twins 49%

Guardians vs. Twins Betting Insights

• This season, the Guardians have won eight out of the 11 games, or 72.7%, in which they've been favored.
• Cleveland has entered five games this season favored by -132 or more and is 4-1 in those contests.
• The moneyline for this contest implies a 56.9% chance of a victory for the Guardians.
• The Twins have been chosen as underdogs in eight games this year and have walked away with the win two times (25%) in those games.
• Minnesota has been listed as an underdog of +111 or more on two occasions this season and lost both games.
• The Twins have an implied victory probability of 47.4% according to the moneyline set for this matchup.

Guardians Recent Betting Performance

• The Guardians were favored on the moneyline in three of their last 10 games, and they went 2-1 in those matchups.
• Over their last 10 matchups (all had set totals), the Guardians combined with their opponents to hit the over on the run total seven times.
• The Guardians have put together a 5-5-0 record against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan leads the Guardians with a .345 batting average.
• Kwan is 62nd in home runs and 52nd in RBI among all hitters in the majors.
• Kwan takes a hitting streak of 11 games into this game. During his last 10 outings he is hitting .410 with four doubles, a home run, three walks and four RBI.
• Ramirez is hitting .265 with four doubles, five home runs and nine walks.
• Ramirez ranks 39th in home runs and 65th in RBI among all hitters in MLB.
• Ramirez carries a two-game streak with at least one hit into this matchup. In his last five games he is hitting .278 with a walk and an RBI.
• Kyle Manzardo has racked up a team-best seven home runs and 18 runs batted in.
• Manzardo is on a two-game hitting streak entering this contest. During his last five outings he is batting .211 with a double, a home run, a walk and two RBI.
• Gabriel Arias has six doubles, four home runs and five walks while batting .271.
• Arias has recorded at least one hit in four games in a row. During his last five outings he is hitting .250 with three doubles and an RBI.

Guardians Team Props

Twins Recent Betting Performance

• The Twins have played as underdogs in four of their past 10 games and won one of those contests.
• In their last 10 games with a total, the Twins and their opponents have combined to hit the over four times.
• The Twins have seven wins against the spread in their last 10 chances.

Twins Recent Stats

Twins Player Insights

• Buxton has a team-leading six home runs and has driven in 17 runs.
• Buxton's home run total puts him 24th in the big leagues, and he is 32nd in RBI.
• Buxton takes a hitting streak of three games into this matchup. In his last five games he is hitting .300 with a triple, two home runs, a walk and seven RBI.
• Ty France has 17 RBI while hitting .248. Each is tops on the club.
• France ranks 145th overall in home runs and 32nd in RBI this season.
• Trevor Larnach is batting .232 with two doubles, four home runs and 13 walks.
• Ryan Jeffers is batting .257 with seven doubles, a home run and nine walks.

Twins Team Props

Twins vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Minnesota Twins and the Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

Minnesota Twins