Guardians vs. Tigers AL Wild Card Game 2 Prediction, Odds, Picks - October 1

The AL Wild Card Series continues on Wednesday when the Cleveland Guardians play host to the Detroit Tigers. The Tigers will look to clinch a berth in the ALDS when the game begins at 1:08 p.m. ET on ESPN Networks. The Guardians are listed as -136 moneyline favorites for this matchup against the Tigers (+115). Cleveland (-1.5) is the favorite on the run line. The over/under is 6.5 runs for this matchup.

Here is everything you need to know from a betting perspective on the Guardians-Tigers game, regarding the run line, moneyline and total, plus expert picks.

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Tigers vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Detroit Tigers and Cleveland Guardians.

Guardians vs. Tigers Game Information & Odds

• When: Wednesday, October 1, 2025 at 1:08 p.m. ET
• Where: Progressive Field in Cleveland, Ohio
• How to watch on TV: ESPN Networks

Guardians vs. Tigers Prediction

• Score Prediction: Guardians 5, Tigers 4
• Total Prediction: Over 6.5 runs
• Win Probabilities: Guardians 53%, Tigers 47%

Guardians vs. Tigers Betting Insights

• The Guardians have entered the game as favorites 72 times this season and won 45, or 62.5%, of those games.
• Cleveland has a record of 23-9, a 71.9% win rate, when favored by -136 or more by oddsmakers this season.
• The Guardians have a 57.6% chance to win this game based on the implied probability of the moneyline.
• The Tigers have won in 24, or 48%, of the 50 contests they have been named as odds-on underdogs this year.
• This season, Detroit has come away with a win eight times in 19 chances when named as an underdog of at least +115 or longer on the moneyline.
• The moneyline set for this matchup implies the Tigers have a 46.5% chance of coming away with a victory in the contest.

Guardians Recent Betting Performance

• The Guardians were the moneyline favorite in seven of their last 10 games, and they went 4-3 in those matchups.
• In their last 10 matchups -- all had a set run total -- the Guardians and their opponents combined to hit the over on the total three times.
• The Guardians' ATS record is 5-5-0 over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez is the bat to watch in the Guardians lineup, leading the team in batting average (.283), home runs (30), and RBI (85).
• Among all batters in baseball, Ramirez's home run total ranks him 30th, and his RBI tally ranks him 42nd.
• Ramirez has collected a hit in three games in a row. In his last five games he is hitting .278 with a double, three walks and an RBI.
• Steven Kwan has 29 doubles, a triple, 11 home runs and 55 walks while hitting .272.
• Of all major league hitters, Kwan ranks 192nd in homers and 142nd in RBI.
• Kyle Manzardo has 19 doubles, two triples, 27 home runs and 48 walks while batting .234.
• Manzardo is on a four-game hitting streak entering this contest. In his last five games he is batting .235 with a double, a home run and two RBIs.
• Angel Martinez is batting .224 with 23 doubles, two triples, 11 home runs and 23 walks.
• Martinez brings a two-game streak with at least one hit into this one. In his last five games he is batting .188 with a walk.

Guardians Team Props

Tigers Recent Betting Performance

• The Tigers have played as underdogs in four of their past 10 games and won two of those contests.
• In their last 10 games with a total, the Tigers and their opponents are 3-7-0 when it comes to hitting the over.
• The Tigers have a record of 1-9-0 ATS over their last 10 games.

Tigers Recent Stats

Tigers Player Insights

• Gleyber Torres has 22 doubles, 16 home runs and 85 walks while hitting .256.
• Among all hitters in the majors, Torres ranks 127th in homers and 73rd in RBI.
• Riley Greene been a consistent power bat this season, as he paces his team with 36 home runs and 111 runs batted in.
• Among all major league hitters, Greene is 10th in home runs and seventh in RBI.
• Spencer Torkelson has 27 doubles, a triple, 31 home runs and 72 walks while batting .240.
• Zach McKinstry leads the Tigers with a .259 batting average.

Tigers Team Props

Tigers vs. Guardians Highlights | MLB on FOX

Check out the best moments between the Detroit Tigers and Cleveland Guardians.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Cleveland Guardians

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