Guardians vs. Nationals Prediction, Odds, Picks - May 5

C.J. Abrams and Bo Naylor take the field when the Washington Nationals and Cleveland Guardians meet on Monday at Nationals Park. The favored Guardians have -123 moneyline odds against the underdog Nationals, who are listed at +103. Cleveland is the run-line favorite (-1.5). A 9-run total is set for this matchup.

Here is everything you need from a betting perspective on the Guardians-Nationals game, regarding the run line, moneyline and total, plus expert picks.

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Guardians vs. Nationals Game Information & Odds

• When: Monday, May 5, 2025 at 6:45 p.m. ET
• Where: Nationals Park in Washington D.C.
• How to watch on TV: MASN and CLEG

Guardians vs. Nationals Prediction

• Score Prediction: Nationals 6, Guardians 5
• Total Prediction: Over 9 runs
• Win Probabilities: Guardians 52%, Nationals 48%

Guardians vs. Nationals Betting Insights

• This season, the Guardians have been favored 13 times and won 10, or 76.9%, of those games.
• Cleveland has a record of 7-2, a 77.8% win rate, when favored by -123 or more by bookmakers this season.
• Bookmakers have implied with the moneyline set for this matchup that the Guardians have a 55.2% chance to win.
• The Nationals have won in 14, or 48.3%, of the 29 contests they have been named as odds-on underdogs this year.
• This season, Washington has come away with a win 12 times in 26 chances when named as an underdog of at least +103 or worse on the moneyline.
• The Nationals have an implied victory probability of 49.3% according to the moneyline set by oddsmakers for this matchup.

Guardians Recent Betting Performance

• The Guardians have a 2-1 record from the three games they were moneyline favorites over their last 10 matchups.
• In their last 10 outings (all had set totals), the Guardians combined with their opponents to go over the run total six times.
• The Guardians have put together a 4-6-0 record against the spread over their past 10 games.

Guardians Recent Stats

Guardians Player Insights

• Steven Kwan is the Guardians best hitter thus far this season, hitting at a team-leading .333 rate along with four homers and 16 RBI.
• Kwan's home runs rank him 89th in MLB, and he is 77th in RBI.
• Kwan carries a three-game hitting streak into this matchup. In his last five games he is hitting .333 with a double, two walks and an RBI.
• Jose Ramirez is hitting .265 with five doubles, five home runs and 10 walks.
• Of all major league hitters, Ramirez ranks 57th in home runs and 85th in RBI.
• Kyle Manzardo paces the Guardians in home runs (eight) and runs batted in (20).
• Carlos Santana is batting .219 with two doubles, three home runs and 15 walks.

Guardians Team Props

Nationals Recent Betting Performance

• The Nationals have played as underdogs in 10 of their past 10 games and won five of those contests.
• In their last 10 games with a total, the Nationals and their opponents are 5-5-0 when it comes to hitting the over.
• The Nationals have won six of their last 10 games against the spread.

Nationals Recent Stats

Nationals Player Insights

• James Wood has swatted a team-leading nine long balls.
• Among all hitters in MLB, Wood ranks sixth in homers and 29th in RBI.
• Wood brings a hitting streak of four games into this game. In his last five games he is hitting .368 with two doubles and four walks.
• Nathaniel Lowe has been productive as he paces his team with 27 runs batted in.
• Lowe ranks 41st in home runs and eighth in RBI among all hitters in the big leagues.
• Luis Garcia has five doubles, three home runs and eight walks while hitting .234.
• Keibert Ruiz leads the team in batting average with a high-water mark of .298.

Nationals Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Washington Nationals

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