Giants vs. Rockies Prediction, Odds, Picks - September 27

Jung Hoo Lee and the San Francisco Giants take on Blaine Crim and the Colorado Rockies on Saturday at 4:05 p.m. ET, in the second of a three-game series at Oracle Park. The Giants are -243 moneyline favorites for this matchup against the Rockies (+197). San Francisco is favored on the run line (-1.5 with -112 odds). The total for the contest has been set at 8 runs.

Here's everything you need to know from a betting perspective on the Giants-Rockies game, regarding the run line, moneyline and total, plus expert picks.

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Cardinals vs. Giants Highlights | MLB on FOX

Enjoy the best moments between the San Francisco Giants and the St. Louis Cardinals.

Giants vs. Rockies Game Information & Odds

• When: Saturday, September 27, 2025 at 4:05 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and COLR

Giants vs. Rockies Prediction

• Score Prediction: Giants 6, Rockies 4
• Total Prediction: Over 8 runs
• Win Probabilities: Giants 61%, Rockies 39%

Giants vs. Rockies Betting Insights

• The Giants have entered the game as favorites 90 times this season and won 47, or 52.2%, of those games.
• This season San Francisco has won four of its five games when favored by at least -243 on the moneyline.
• The bookmakers' moneyline implies a 70.8% chance of a victory for the Giants.
• The Rockies have been underdogs in 155 games this season and have come away with the win 41 times (26.5%) in those contests.
• Colorado has a mark of 15-60 in contests where sportsbooks favor it by +197 or worse on the moneyline.
• The Rockies have an implied victory probability of 33.7% according to the moneyline set by sportsbooks for this matchup.

Giants Recent Betting Performance

• The Giants have a 1-2 record from the three games they were favored on the moneyline over their last 10 matchups.
• In their last 10 outings -- all had a set run total -- the Giants and their opponents combined to go over the total five times.
• The Giants' ATS record is 6-4-0 over their past 10 games.

Giants Recent Stats

Giants Player Insights

• The Giants' best power option comes in the form of Rafael Devers and his 34-home-run 107-RBI season, both team highs.
• Devers' home runs place him 13th in MLB, and he is ninth in RBI.
• Devers brings a hitting streak of six games into this game. During his last 10 games he is batting .211 with a double, three home runs, eight walks and five RBIs.
• Lee's .264 batting average leads his team.
• Lee ranks 250th in homers and 151st in RBI in the major leagues.
• Lee enters this matchup looking for his fourth game in a row with a hit. During his last five outings he is hitting .350 with a double, a triple and an RBI.
• Willy Adames is batting .226 with 22 doubles, two triples, 29 home runs and 80 walks.
• Adames is on a three-game hitting streak entering this contest. During his last five outings he is hitting .200 with a double, a home run, two walks and four RBIs.
• Heliot Ramos is batting .258 with 24 doubles, a triple, 21 home runs and 51 walks.
• Ramos is riding a four-game hitting streak into this one. During his last five outings he is batting .250 with three home runs and seven RBIs.

Giants Team Props

Rockies Recent Betting Performance

• In nine games as underdogs over the last 10 matchups, the Rockies have a record of 1-8.
• The Rockies and their opponents have combined to hit the over seven times in their last 10 games with a total.
• The Rockies have four wins against the spread in their last 10 chances.

Rockies Recent Stats

Rockies Player Insights

• Hunter Goodman leads the Rockies in home runs (30), runs batted in (90) and has a team-best batting average of .276.
• Among all hitters in the big leagues, Goodman's home run total is 26th and his RBI tally ranks 29th.
• Mickey Moniak is hitting .270 with 20 doubles, eight triples, 24 home runs and 22 walks.
• Moniak ranks 55th in home runs and 93rd in RBI among all major league hitters this year.
• Jordan Beck has 27 doubles, five triples, 15 home runs and 43 walks while hitting .260.
• Tyler Freeman is hitting .281 with 20 doubles, two triples, two home runs and 34 walks.

Rockies Team Props

Cardinals vs. Giants Highlights | MLB on FOX

Enjoy the best moments between the San Francisco Giants and the St. Louis Cardinals.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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