Cubs vs. White Sox Prediction, Odds, Picks - May 18

The Chicago Cubs and Chicago White Sox will play on Sunday at Wrigley Field, at 2:20 p.m. ET, with Kyle Tucker and Miguel Vargas -- two hot hitters -- expected to produce at the plate. The Cubs are favored in this one, at -272, while the underdog White Sox have +222 odds to upset. The Cubs are favored on the run line (-1.5). A 7.5-run total has been listed for the matchup.

Here's everything you need to know from a betting perspective on the Cubs-White Sox game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

White Sox vs. Cubs Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Chicago Cubs.

Cubs vs. White Sox Game Information & Odds

• When: Sunday, May 18, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MARQ and CHSN

Cubs vs. White Sox Prediction

• Score Prediction: Cubs 6, White Sox 4
• Total Prediction: Over 7.5 runs
• Win Probabilities: Cubs 60%, White Sox 40%

Cubs vs. White Sox Betting Insights

• This season, the Cubs have been favored 27 times and won 18, or 66.7%, of those games.
• The Cubs have played as a favorite of -272 or more once this season and won that game.
• Sportsbooks have implied with the moneyline set for this matchup that the Cubs have a 73.1% chance to win.
• The White Sox have come away with 14 wins in the 46 contests they have been listed as the underdogs in this season.
• This season, the White Sox have come away with a win one time in four chances when named as an underdog of at least +222 or longer on the moneyline.
• The White Sox have an implied victory probability of 31.1% according to the moneyline set by sportsbooks for this matchup.

Cubs Recent Betting Performance

• The Cubs went 4-3 over the seven games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 matchups (all 10 of them had set totals), the Cubs and their opponents combined to hit the over five times.
• The Cubs have gone 4-6-0 against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Tucker has nine doubles, four triples, 10 home runs and 33 walks while hitting .264.
• Among all MLB hitters, Tucker ranks 61st in batting average, 27th in on-base percentage, and 16th in slugging.
• Pete Crow-Armstrong has shown off his power as he leads his team with 12 home runs and 38 RBI, with a team-best .285 batting average.
• Crow-Armstrong ranks seventh in homers and third in RBI on the year.
• Crow-Armstrong carries a four-game streak with at least one hit into this contest. In his last five games he is hitting .450 with a triple, two home runs, a walk and 10 RBIs.
• Dansby Swanson is batting .253 with seven doubles, a triple, 10 home runs and 17 walks.
• Swanson is on a three-game hitting streak entering this contest. During his last five outings he is hitting .353 with two home runs, four walks and four RBIs.
• Seiya Suzuki is batting .244 with 10 doubles, two triples, 11 home runs and 14 walks.
• Suzuki is riding a three-game hitting streak into this one. In his last five games he is hitting .250 with three doubles, two home runs, a walk and five RBIs.

Cubs Team Props

White Sox Recent Betting Performance

• The White Sox have played as underdogs in 10 of their past 10 games and won four of those contests.
• In their last 10 games with a total, the White Sox and their opponents have combined to hit the over two times.
• The White Sox have a record of 5-5-0 ATS over their last 10 games.

White Sox Recent Stats

White Sox Player Insights

• Vargas paces the White Sox in home runs (five) and runs batted in (20).
• Among all batters in MLB, Vargas ranks 104th in home runs and 93rd in RBI.
• Luis Robert has put his power on display as he paces his team with five home runs.
• Robert is 104th in home runs and 132nd in RBI among all hitters in the big leagues.
• Lenyn Sosa has racked up a team-best batting average of .261.
• Andrew Vaughn has swatted a team-leading five long balls.

White Sox Team Props

White Sox vs. Cubs Highlights | MLB on FOX

Check out the best moments between the Chicago White Sox and the Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Chicago Cubs

Chicago White Sox