Cubs vs. White Sox Prediction, Odds, Picks - July 26

Matt Shaw and the Chicago Cubs will square off against Miguel Vargas and the Chicago White Sox at Rate Field in the second of a three-game series, Saturday at 7:10 p.m. ET. The favored Cubs have -194 moneyline odds to win against the underdog White Sox, who are listed at +161. The Cubs are a 1.5-run favorite (at -119 odds). A 9-run over/under is set in this matchup.

Here is everything you need from a betting perspective on the Cubs-White Sox game, regarding the run line, moneyline and total, plus expert picks.

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Check out the best highlights between the Chicago White Sox and Chicago Cubs.

Cubs vs. White Sox Game Information & Odds

• When: Saturday, July 26, 2025 at 7:10 p.m. ET
• Where: Rate Field in Chicago, Illinois
• How to watch on TV: CHSN and MARQ

Cubs vs. White Sox Prediction

• Score Prediction: Cubs 5, White Sox 4
• Total Prediction: Over 9 runs
• Win Probabilities: Cubs 52%, White Sox 48%

Cubs vs. White Sox Betting Insights

• The Cubs have entered the game as favorites 71 times this season and won 48, or 67.6%, of those games.
• This season, the Cubs have won 13 of their 14 games, or 92.9%, when favored by at least -194 on the moneyline.
• The oddsmakers' moneyline implies a 66% chance of a victory for the Cubs.
• The White Sox have been victorious in 37, or 36.3%, of the 102 contests they have been chosen as underdogs in this season.
• This season, the White Sox have come away with a win 13 times in 49 chances when named as an underdog of at least +161 or longer on the moneyline.
• The White Sox have an implied victory probability of 38.3% according to the moneyline set by sportsbooks for this matchup.

Cubs Recent Betting Performance

• The Cubs played as the moneyline favorite for six of their last 10 games, and finished 3-3 in those matchups.
• Over their last 10 outings (all 10 of them had set totals), the Cubs and their opponents combined to go over the run total five times.
• The Cubs have gone 5-5-0 against the spread over their past 10 games.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker is batting .275 with 19 doubles, four triples, 18 home runs and 66 walks.
• In all of MLB, Tucker ranks 36th in homers and 40th in RBI.
• Pete Crow-Armstrong's 27 home runs are a team-high mark.
• Crow-Armstrong is sixth in home runs and ninth in RBI on the year.
• Seiya Suzuki has racked up a team-high 81 runs batted in.
• Nico Hoerner has a club-high .286 batting average.
• Hoerner takes a three-game streak with at least one hit into this one. During his last five outings he is hitting .286 with an RBI.

Cubs Team Props

White Sox Recent Betting Performance

• In 10 games as underdogs over the last 10 matchups, the White Sox have a record of 7-3.
• When it comes to hitting the over, the White Sox and their opponents are 7-3-0 in their last 10 games with a total.
• The White Sox have nine wins against the spread in their last 10 chances.

White Sox Recent Stats

White Sox Player Insights

• Vargas leads the White Sox in home runs (12) and runs batted in (41).
• Vargas' home run total puts him 101st in the big leagues, and he is 110th in RBI.
• Andrew Benintendi is batting .235 with 12 doubles, two triples, 11 home runs and 27 walks.
• Among all major league hitters, Benintendi is 113th in homers and 133rd in RBI.
• Chase Meidroth has 11 doubles, three home runs and 32 walks while hitting .256.
• Luis Robert has recorded a team-high 41 runs batted in.

White Sox Team Props

Cubs vs. White Sox Highlights | MLB on FOX

Check out the best highlights between the Chicago White Sox and Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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