Brewers vs. Cubs Prediction, Odds, Picks - August 21

William Contreras and the Milwaukee Brewers will try to beat Shota Imanaga, the Chicago Cubs' starting pitcher, on Thursday at 2:20 p.m. ET. The Cubs are listed as +100 moneyline underdogs in this matchup against the favorite Brewers (-119). Milwaukee (-1.5) is favored on the run line. The matchup's total is set at 6.5 runs.

Take a look at everything you need to know from a betting perspective on the Brewers-Cubs game, regarding the run line, moneyline and total, plus expert picks.

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Brewers vs. Cubs Game 2 Highlights | MLB on FOX

Check out the best moments between the Milwaukee Brewers and the Chicago Cubs.

Brewers vs. Cubs Game Information & Odds

• When: Thursday, August 21, 2025 at 2:20 p.m. ET
• Where: Wrigley Field in Chicago, Illinois
• How to watch on TV: MLB Network, MARQ, and FDSWI

Brewers vs. Cubs Prediction

• Score Prediction: Cubs 5, Brewers 4
• Total Prediction: Over 6.5 runs
• Win Probabilities: Brewers 51%, Cubs 49%

Brewers vs. Cubs Betting Insights

• The Brewers have won 47, or 69.1%, of the 68 games they've played as favorites this season.
• Milwaukee has a record of 41-19 in games when sportsbooks favor them by at least -119 on the moneyline.
• The sportsbooks' moneyline implies a 54.3% chance of a victory for the Brewers.
• The Cubs have been chosen as underdogs in 38 games this year and have walked away with the win 16 times (42.1%) in those games.
• This season, Chicago has come away with a win 11 times in 26 chances when named as an underdog of at least +100 or longer on the moneyline.
• Oddsmakers have implied with the moneyline set for this matchup that the Cubs have a 50% chance of pulling out a win.

Brewers Recent Betting Performance

• The Brewers have a 5-2 record from the seven games they were favored on the moneyline over their last 10 matchups.
• Over their last 10 matchups, the Brewers and their opponents combined to go over the total six times (all 10 games had set totals).
• The Brewers' ATS record is 6-4-0 over their past 10 games.

Brewers Recent Stats

Brewers Player Insights

• Christian Yelich leads the Brewers in home runs (26) and runs batted in (87).
• In all of Major League Baseball, Yelich ranks 16th in homers and eighth in RBI.
• William Contreras has 22 doubles, 13 home runs and 70 walks while batting .258.
• Contreras is 117th in homers and 64th in RBI in the bigs.
• Brice Turang is batting .284 with 24 doubles, 13 home runs and 47 walks.
• Turang is on a four-game hitting streak entering this contest. In his last five games he is batting .412 with a double, a home run, a walk and four RBIs.
• Sal Frelick is batting .298 to pace his team.
• Frelick has recorded at least one hit in four straight games. During his last five outings he is hitting .286 with a double, four walks and two RBIs.

Brewers Team Props

Cubs Recent Betting Performance

• The Cubs have played as underdogs in four of their past 10 games and have gone 3-1 in those contests.
• When it comes to hitting the over, the Cubs and their opponents are 2-7-1 in their last 10 games with a total.
• The Cubs have five wins against the spread in their last 10 chances.

Cubs Recent Stats

Cubs Player Insights

• Kyle Tucker is hitting .261 with 21 doubles, four triples, 18 home runs and 79 walks, while getting on base at a rate of .374.
• Tucker is 61st in homers and 59th in RBI among all hitters in the big leagues.
• Pete Crow-Armstrong has collected a team-best 27 home runs.
• Crow-Armstrong ranks 13th in home runs and 17th in RBI among all hitters in the big leagues.
• Seiya Suzuki has been solid source of run production for the Cubs with 27 long balls and 86 runs batted in.
• Nico Hoerner leads the team in batting average with a high-water mark of .289.

Cubs Team Props

Brewers vs. Cubs Game 2 Highlights | MLB on FOX

Check out the best moments between the Milwaukee Brewers and the Chicago Cubs.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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