Astros vs. Red Sox Prediction, Odds, Picks - August 12

Jose Altuve and Jarren Duran are the hottest hitters on the Houston Astros and Boston Red Sox, who meet on Tuesday at Daikin Park, at 8:10 p.m. ET. Bookmakers list the Astros as -168 moneyline favorites, while giving the underdog Red Sox +140 moneyline odds. Houston is a 1.5-run favorite (at +126 odds). The total for the matchup is listed at 8 runs.

Check out everything you need to know from a betting perspective on the Astros-Red Sox game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Red Sox Game Information & Odds

• When: Tuesday, August 12, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and NESN

Astros vs. Red Sox Prediction

• Score Prediction: Astros 5, Red Sox 4
• Total Prediction: Over 8 runs
• Win Probabilities: Astros 52%, Red Sox 48%

Astros vs. Red Sox Betting Insights

• This season, the Astros have won 43 out of the 80 games, or 53.8%, in which they've been favored.
• This season Houston has won nine of its 17 games, or 52.9%, when favored by at least -168 on the moneyline.
• Sportsbooks have implied with the moneyline set for this matchup that the Astros have a 62.7% chance to win.
• The Red Sox have been chosen as underdogs in 45 games this year and have walked away with the win 21 times (46.7%) in those games.
• Boston has a win-loss record of 6-5 when favored by +140 or worse by bookmakers this year.
• The moneyline set for this matchup implies the Red Sox have a 41.7% chance of walking away with the win.

Astros Recent Betting Performance

• The Astros went 1-3 across the four games they were moneyline favorites in their last 10 matchups.
• Over their last 10 outings (all 10 of them had set totals), the Astros and their opponents combined to go over the run total seven times.
• The Astros are 5-5-0 against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Altuve has gone yard 21 times this season, the highest mark on the Astros, while hitting .287 with 63 RBI.
• Among all batters in MLB, Altuve is 31st in homers and 48th in RBI.
• Altuve brings a hitting streak of nine games into this game. In his last 10 outings he is batting .317 with a double, three home runs, five walks and six RBIs.
• Jeremy Pena has a club-leading .314 batting average.
• Of all major league hitters, Pena is 120th in home runs and 129th in RBI.
• Yainer Diaz is batting .249 with 16 doubles, a triple, 16 home runs and 15 walks.
• Christian Walker's 65 runs batted in are a team-high mark.
• Walker takes a two-game streak with at least one hit into this one. During his last five outings he is hitting .316 with three doubles, a home run, four walks and six RBIs.

Astros Team Props

Red Sox Recent Betting Performance

• The Red Sox have played as underdogs in five of their past 10 games and have gone 3-2 in those contests.
• In their last 10 games with a total, the Red Sox and their opponents are 8-2-0 when it comes to hitting the over.
• Over their last 10 games, the Red Sox are 7-3-0 against the spread.

Red Sox Recent Stats

Red Sox Player Insights

• Duran paces the Red Sox with a team-leading batting average of .265.
• Among all batters in the big leagues, Duran ranks 120th in home runs and 36th in RBI.
• Ceddanne Rafaela is batting .259 with 24 doubles, three triples, 14 home runs and 20 walks.
• Among all major league hitters, Rafaela is 97th in home runs and 90th in RBI.
• Trevor Story leads the Red Sox with 73 runs batted in.
• Wilyer Abreu paces the Red Sox with 21 long balls.

Red Sox Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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