Astros vs. Mariners Prediction, Odds, Picks - September 19

Jeremy Pena and the Houston Astros will play Julio Rodriguez and the Seattle Mariners at Daikin Park in the first of a three-game series, on Friday at 8:10 p.m. ET. Bookmakers list the Astros as -111 moneyline favorites, while giving the underdog Mariners -109 moneyline odds. Seattle is favored on the run line (-1.5). The total for the contest has been set at 7.5 runs.

Take a look at everything you need to know from a betting perspective on the Astros-Mariners game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Mariners Game Information & Odds

• When: Friday, September 19, 2025 at 8:10 p.m. ET
• Where: Daikin Park in Houston, Texas
• How to watch on TV: SCHN and ROOT Sports NW

Astros vs. Mariners Prediction

• Score Prediction: Astros 4, Mariners 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Astros 52%, Mariners 48%

Astros vs. Mariners Betting Insights

• The Astros have won 52, or 53.1%, of the 98 games they've played as favorites this season.
• This season Houston has won 52 of its 98 games, or 53.1%, when favored by at least -111 on the moneyline.
• The moneyline for this contest implies a 52.6% chance of a victory for the Astros.
• The Mariners have been chosen as underdogs in 45 games this year and have walked away with the win 21 times (46.7%) in those games.
• Seattle has a mark of 20-22 in contests where bookmakers favor it by -109 or worse on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Mariners have a 52.2% chance of pulling out a win.

Astros Recent Betting Performance

• The Astros were favored on the moneyline in four of their last 10 games, and they went 2-2 in those matchups.
• In their last 10 matchups (all 10 of them had set totals), the Astros and their opponents combined to hit the over four times.
• The Astros' ATS record is 7-3-0 over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve leads the Astros with 26 home runs on the year. He's also hitting .263 with 74 RBI.
• In all of MLB, Altuve ranks 39th in homers and 62nd in RBI.
• Altuve has collected a hit in two straight games. In his last five games he is hitting .313 with two home runs and five RBIs.
• Pena is batting .305 to pace his team.
• Pena ranks 117th in homers and 121st in RBI on the season.
• Pena has six straight games with at least one hit. In his last 10 outings he is batting .318 with four doubles, a home run, two walks and five RBIs.
• Yainer Diaz has 23 doubles, a triple, 19 home runs and 20 walks while hitting .257.
• Diaz has at least one base hit in two games in a row. During his last five outings he is hitting .333 with a double and five RBIs.
• Carlos Correa is hitting .276 with 26 doubles, 13 home runs and 41 walks.
• Correa takes a three-game streak with at least one hit into this one. During his last five outings he is hitting .316 with two doubles and three walks.

Astros Team Props

Mariners Recent Betting Performance

• The Mariners have been underdogs once in the past 10 games and lost that contest.
• In their last 10 games with a total, the Mariners and their opponents have combined to hit the over six times.
• The Mariners have seven wins against the spread in their last 10 chances.

Mariners Recent Stats

Mariners Player Insights

• Cal Raleigh leads the Mariners with 56 long balls and runs batted in, driving in 118.
• In all of the majors, Raleigh ranks first in homers and third in RBI.
• Raleigh takes a hitting streak of six games into this matchup. During his last 10 games he is batting .314 with three doubles, three home runs, 10 walks and five RBIs.
• Rodriguez has 31 doubles, four triples, 30 home runs and 38 walks while hitting .269.
• Rodriguez is 16th in home runs and 18th in RBI among all major league batters this year.
• Josh Naylor paces the Mariners' lineup with a .287 batting average.
• Eugenio Suarez is hitting .228 with 26 doubles, 46 home runs and 44 walks.

Mariners Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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