Astros vs. Athletics Prediction, Odds, Picks - September 25

Jeremy Pena and the Houston Astros take on Shea Langeliers and the Athletics on Thursday at 3:35 p.m. ET, in the final of a three-game series at Sutter Health Park. The Astros are favored in this one, at -117, while the underdog Athletics have -103 odds to play spoiler. The Astros are a 1.5-run favorite (at +135 odds). The total is 9.5 runs for the contest (with -110 odds to hit the over and -110 odds on the under).

Here's everything you need to know from a betting perspective on the Astros-Athletics game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Athletics Game Information & Odds

• When: Thursday, September 25, 2025 at 3:35 p.m. ET
• Where: Sutter Health Park in West Sacramento, California
• How to watch on TV: NBCS-CA and SCHN

Astros vs. Athletics Prediction

• Score Prediction: Athletics 5, Astros 4
• Total Prediction: Under 9.5 runs
• Win Probabilities: Astros 52%, Athletics 48%

Astros vs. Athletics Betting Insights

• The Astros have won 52, or 51.5%, of the 101 games they've played as favorites this season.
• The Astros have a record of 44-39, a 53% win rate, when they're favored by -117 or more by oddsmakers this season.
• The sportsbooks' moneyline implies a 53.9% chance of a victory for the Astros.
• The Athletics have been underdogs in 118 games this season and have come away with the win 56 times (47.5%) in those contests.
• This season, the Athletics have come away with a win 48 times in 108 chances when named as an underdog of at least -103 or longer on the moneyline.
• The Athletics have an implied victory probability of 50.7% according to the moneyline set for this matchup.

Astros Recent Betting Performance

• The Astros were the moneyline favorite for six of their last 10 games, and went 2-4 in those matchups.
• Over their last 10 matchups, the Astros and their opponents combined to hit the over on the total five times (all 10 games had set totals).
• The Astros have put together a 4-6-0 record against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve's 26 round-trippers in 2025 are the most on the Astros. He's also driven in 75 runs while hitting .263.
• Among all hitters in MLB, Altuve's home run total ranks him 39th, and his RBI tally ranks him 64th.
• Pena's .304 batting average leads his team.
• Pena ranks 110th in home runs and 108th in RBI among all hitters in baseball.
• Yainer Diaz is batting .254 with 23 doubles, a triple, 19 home runs and 20 walks.
• Carlos Correa has 28 doubles, 13 home runs and 43 walks while hitting .274.

Astros Team Props

Athletics Recent Betting Performance

• The Athletics have played as underdogs in seven of their past 10 games and won five of those contests.
• In their last 10 games with a total, the Athletics and their opponents are 3-6-1 when it comes to hitting the over.
• The Athletics have seven wins against the spread in their last 10 chances.

Athletics Recent Stats

Athletics Player Insights

• Brent Rooker has 40 doubles, three triples, 30 home runs and 62 walks while batting .264.
• In all of the majors, Rooker ranks 24th in home runs and 29th in RBI.
• Tyler Soderstrom has been productive as he leads his team with 93 RBI.
• Soderstrom is currently 46th in home runs and 21st in RBI in the major leagues.
• Jacob Wilson has a team-high batting average of .315.
• Nick Kurtz leads the Athletics with 33 long balls.

Athletics Team Props

Astros vs. Athletics Highlights | MLB on FOX

Enjoy the best moments between the Houston Astros vs. Athletics.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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