Astros vs. Angels Prediction, Odds, Picks - September 26

The Los Angeles Angels and Taylor Ward hit the field against Jeremy Pena and the Houston Astros on Friday, in the first game of a three-game series at Angel Stadium. The Astros are the favorite in this one, at -132, while the underdog Angels have +112 odds to win. Houston is the run-line favorite (-1.5). The over/under is 9 runs for this game.

Take a look at everything you need to know from a betting perspective on the Astros-Angels game, regarding the run line, moneyline and total, plus expert picks.

Keep up with MLB on FOX Sports.

Royals vs. Angels Highlights | MLB on FOX

Check out the best moments between the Kansas City Royals and Los Angeles Angels.

Astros vs. Angels Game Information & Odds

• When: Friday, September 26, 2025 at 9:38 p.m. ET
• Where: Angel Stadium in Anaheim, California
• How to watch on TV: FDSW and SCHN

Astros vs. Angels Prediction

• Score Prediction: Astros 5, Angels 4
• Total Prediction: Under 9 runs
• Win Probabilities: Astros 51%, Angels 49%

Astros vs. Angels Betting Insights

• The Astros have won 53, or 52%, of the 102 games they've played as favorites this season.
• Houston has entered 59 games this season favored by -132 or more and is 33-26 in those contests.
• Oddsmakers have implied with the moneyline set for this matchup that the Astros have a 56.9% chance to win.
• The Angels have been underdogs in 120 games this season and have come away with the win 52 times (43.3%) in those contests.
• This season, Los Angeles has come away with a win 40 times in 97 chances when named as an underdog of at least +112 or worse on the moneyline.
• The Angels have an implied victory probability of 47.2% according to the moneyline set by oddsmakers for this matchup.

Astros Recent Betting Performance

• The Astros were the moneyline favorite for six of their last 10 games, and they finished 2-4 in those matchups.
• In their last 10 matchups (all 10 of them had set totals), the Astros and their opponents combined to go over the run total six times.
• The Astros have put together a 4-6-0 record against the spread over their past 10 games.

Astros Recent Stats

Astros Player Insights

• Jose Altuve has a team-high 26 home runs.
• Including all MLB hitters, Altuve is 52nd in batting average, 77th in on-base percentage, and 63rd in slugging.
• Altuve has collected a hit in two straight games. In his last five games he is batting .412 with two doubles, three walks and three RBIs.
• Pena's .304 batting average paces his team.
• Pena is 111th in home runs and 109th in RBI on the season.
• Yainer Diaz has 23 doubles, a triple, 19 home runs and 20 walks while hitting .253.
• Carlos Correa is hitting .274 with 29 doubles, 13 home runs and 45 walks.
• Correa is riding a two-game hitting streak into this one. During his last five outings he is batting .222 with two doubles, four walks and two RBIs.

Astros Team Props

Angels Recent Betting Performance

• In eight games as underdogs over the last 10 matchups, the Angels have a record of 1-7.
• When it comes to hitting the over, the Angels and their opponents are 6-4-0 in their last 10 games with a total.
• The Angels are 2-8-0 ATS over their last 10 games.

Angels Recent Stats

Angels Player Insights

• Ward has driven in the most runs for the Angels with 103 runs batted in.
• Among all hitters in the majors, Ward's home run total ranks 10th and his RBI tally ranks 11th.
• Ward carries a seven-game hitting streak into this matchup. During his last 10 games he is hitting .282 with six home runs and six RBIs.
• Jo Adell has put his power on display as he leads his team with 37 home runs.
• Adell is eighth in home runs and 17th in RBI among all hitters in the big leagues.
• Nolan Schanuel has a team-high batting average of .267.
• Mike Trout has 14 doubles, a triple, 23 home runs and 86 walks while hitting .228.

Angels Team Props

Astros vs. Athletics Highlights | MLB on FOX

Check out the best highlights between the Houston Astros and Athletics.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox? Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.

FOLLOW Follow your favorites to personalize your FOX Sports experience

Los Angeles Angels

Houston Astros