Virginia vs. Stanford Prediction, Odds, Picks - September 20, 2025

The Stanford Cardinal (1-2) are 16.5-point underdogs in a road ACC matchup with the Virginia Cavaliers (2-1) on Saturday, September 20, 2025 at Scott Stadium. This matchup has an over/under of 49.5 points.

The Cavaliers beat the William & Mary Tribe, 55-16, in their most recent contest. The Cardinal beat the Boston College Eagles, 30-20, in their last contest.

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Virginia vs. Stanford Game Information & Odds

• When: Saturday, September 20, 2025 at 7:30 p.m. ET
• Location: Scott Stadium in Charlottesville, Virginia
• TV: ACC Network
• Live Box Score on FOX Sports

Virginia vs. Stanford Prediction

• Pick ATS: Stanford (+16.5)
  
• Pick OU: Over (49.5)
  
• Prediction: Virginia 28, Stanford 23

Predictions are made by the Data Skrive betting model.

Learn more about the Virginia Cavaliers vs. the Stanford Cardinal game on FOX Sports!

Virginia vs. Stanford Betting Insights

• Per the spread and over/under, the implied score for the tilt is Cavaliers 33, Cardinal 16.
• The Cavaliers have an 89.0% chance to win this meeting per the moneyline's implied probability. The Cardinal hold a 15.3% implied probability.
• Virginia has covered twice in three games with a spread this season.
• Stanford has a record of 1-2-0 against the spread this season.

Virginia vs. Stanford: 2025 Stats Comparison

Virginia 2025 Key Players

Stanford 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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