Virginia vs. Stanford Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

Data Skrive

The Stanford Cardinal (1-2) are 16.5-point underdogs in a road ACC matchup with the Virginia Cavaliers (2-1) on Saturday, September 20, 2025 at Scott Stadium. This matchup has an over/under of 49.5 points.

The Cavaliers beat the William & Mary Tribe, 55-16, in their most recent contest. The Cardinal beat the Boston College Eagles, 30-20, in their last contest.

Keep up with college football all season on FOX Sports.

Virginia vs. Stanford Game Information & Odds

When: Saturday, September 20, 2025 at 7:30 p.m. ET
Location: Scott Stadium in Charlottesville, Virginia
TV: ACC Network
Live Box Score on FOX Sports

Virginia vs Stanford Betting Information updated as of September 20, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Virginia	-16.5 (-111)	-813	+553	49.5	-106	-114

Virginia vs. Stanford Prediction

Pick ATS: Stanford (+16.5)
Pick OU: Over (49.5)
Prediction: Virginia 28, Stanford 23

Predictions are made by the Data Skrive betting model.

Learn more about the Virginia Cavaliers vs. the Stanford Cardinal game on FOX Sports!

Virginia vs. Stanford Betting Insights

Per the spread and over/under, the implied score for the tilt is Cavaliers 33, Cardinal 16.
The Cavaliers have an 89.0% chance to win this meeting per the moneyline's implied probability. The Cardinal hold a 15.3% implied probability.
Virginia has covered twice in three games with a spread this season.
Stanford has a record of 1-2-0 against the spread this season.

Virginia vs. Stanford: 2025 Stats Comparison

	Virginia	Stanford
Off. Points per Game (Rank)	44.7 (14)	17.7 (117)
Def. Points per Game (Rank)	19.3 (61)	23.3 (78)
Turnovers Allowed (Rank)	2 (27)	4 (78)
Turnovers Forced (Rank)	1 (120)	4 (47)

Virginia 2025 Key Players

Name	Position	Stats
J'mari Taylor	RB	213 YDS / 6 TD / 71 YPG / 6.5 YPC
Chandler Morris	QB	670 YDS (69.7%) / 4 TD / 1 INT 113 RUSH YDS / 0 RUSH TD / 37.7 RUSH YPG
Harrison Waylee	RB	169 YDS / 4 TD / 84.5 YPG / 9.9 YPC
Cameron Ross	WR	12 REC / 164 YDS / 1 TD / 54.7 YPG
Ethan Minter	DB	8 TKL / 2 TFL / 1 INT / 1 PD
Landon Danley	LB	15 TKL / 1 TFL
Devin Neal	DB	10 TKL / 1 TFL / 0.5 SACK
James Jackson	LB	10 TKL / 0 TFL

Stanford 2025 Key Players

Name	Position	Stats
Micah Ford	RB	291 YDS / 2 TD / 97 YPG / 5.3 YPC
Bryce Farrell	WR	10 REC / 140 YDS / 0 TD / 70 YPG
Sam Roush	TE	7 REC / 87 YDS / 1 TD / 29 YPG
Ben Gulbranson	QB	437 YDS (53.6%) / 1 TD / 3 INT
Matt Rose	LB	20 TKL / 2 TFL / 1 SACK
Clay Patterson	DL	5 TKL / 2 TFL / 3 SACK
Hunter Barth	LB	9 TKL / 3 TFL / 2 SACK
Collin Wright	DB	8 TKL / 0 TFL / 1 INT / 1 PD