Virginia Tech vs. Wake Forest Prediction, Odds, Picks - October 4, 2025

Updated Oct. 4, 2025 9:04 a.m. ET

FOX Sports

The Virginia Tech Hokies (2-3) are 6-point favorites when they host the Wake Forest Demon Deacons (2-2) in an ACC matchup on Saturday, October 4, 2025 at Lane Stadium. The game has an over/under of 51 points.

The Hokies' most recent game was versus the North Carolina State Wolfpack, and they won by a score of 23-21. The Demon Deacons' last game was versus the Georgia Tech Yellow Jackets, and they lost by a score of 30-29.

Keep up with college football all season on FOX Sports.

Virginia Tech vs. Wake Forest Game Information & Odds

When: Saturday, October 4, 2025 at 1 p.m. ET
Location: Lane Stadium in Blacksburg, Virginia
TV: The CW
Live Box Score on FOX Sports

Virginia Tech vs Wake Forest Betting Information updated as of October 4, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Virginia Tech	-6 (-112)	-229	+189	51	-110	-110

Virginia Tech vs. Wake Forest Prediction

Pick ATS: Virginia Tech (-6)
Pick OU: Under (51)
Prediction: Virginia Tech 28, Wake Forest 21

Predictions are made by the Data Skrive betting model.

Learn more about the Virginia Tech Hokies vs. the Wake Forest Demon Deacons game on FOX Sports!

Virginia Tech vs. Wake Forest Betting Insights

Per the spread and over/under, the implied score for the matchup is Hokies 28, Demon Deacons 22.
The Hokies have a 69.6% chance to claim victory in this meeting per the moneyline's implied probability. The Demon Deacons hold a 34.6% implied probability.
Virginia Tech has covered just once in five matchups with a spread this season.
Wake Forest has won two games against the spread this year.

Virginia Tech vs. Wake Forest: 2025 Stats Comparison

	Virginia Tech	Wake Forest
Off. Points per Game (Rank)	23.6 (91)	26.3 (101)
Def. Points per Game (Rank)	28 (105)	20.8 (41)
Turnovers Allowed (Rank)	7 (99)	5 (53)
Turnovers Forced (Rank)	4 (93)	3 (111)

Virginia Tech 2025 Key Players

Name	Position	Stats
Kyron Drones	QB	1,105 YDS (62.1%) / 8 TD / 3 INT 158 RUSH YDS / 4 RUSH TD / 31.6 RUSH YPG
Marcellous Hawkins	RB	234 YDS / 0 TD / 46.8 YPG / 5.3 YPC 9 REC / 60 REC YDS / 1 REC TD / 12 REC YPG
Donavon Greene	WR	12 REC / 215 YDS / 2 TD / 43 YPG
Ayden Greene	WR	15 REC / 244 YDS / 1 TD / 48.8 YPG
Isaiah Cash	DB	22 TKL / 1 TFL / 1 SACK
Ben Bell	DL	14 TKL / 2 TFL / 1.5 SACK
Kemari Copeland	DL	17 TKL / 0 TFL / 1 SACK / 1 INT
Jaden Keller	LB	17 TKL / 0 TFL / 0.5 SACK

Wake Forest 2025 Key Players

Name	Position	Stats
Robby Ashford	QB	916 YDS (59.3%) / 1 TD / 3 INT 211 RUSH YDS / 4 RUSH TD / 52.8 RUSH YPG
Demond Claiborne	RB	366 YDS / 6 TD / 91.5 YPG / 8 YPC 12 REC / 40 REC YDS / 0 REC TD / 13.3 REC YPG
Chris Barnes	WR	15 REC / 287 YDS / 0 TD / 71.8 YPG
Sterling Berkhalter	WR	10 REC / 199 YDS / 1 TD / 49.8 YPG
Langston Hardy	DL	21 TKL / 3 TFL / 2.5 SACK
Nick Andersen	DB	35 TKL / 1 TFL
Dylan Hazen	LB	25 TKL / 3 TFL
Jayden Loving	DL	13 TKL / 4 TFL / 2 SACK