Virginia Tech vs. Wake Forest Prediction, Odds, Picks - October 4, 2025

The Virginia Tech Hokies (2-3) are 6-point favorites when they host the Wake Forest Demon Deacons (2-2) in an ACC matchup on Saturday, October 4, 2025 at Lane Stadium. The game has an over/under of 51 points.

The Hokies' most recent game was versus the North Carolina State Wolfpack, and they won by a score of 23-21. The Demon Deacons' last game was versus the Georgia Tech Yellow Jackets, and they lost by a score of 30-29.

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Virginia Tech vs. Wake Forest Game Information & Odds

• When: Saturday, October 4, 2025 at 1 p.m. ET
• Location: Lane Stadium in Blacksburg, Virginia
• TV: The CW
• Live Box Score on FOX Sports

Virginia Tech vs. Wake Forest Prediction

• Pick ATS: Virginia Tech (-6)
  
• Pick OU: Under (51)
  
• Prediction: Virginia Tech 28, Wake Forest 21

Predictions are made by the Data Skrive betting model.

Learn more about the Virginia Tech Hokies vs. the Wake Forest Demon Deacons game on FOX Sports!

Virginia Tech vs. Wake Forest Betting Insights

• Per the spread and over/under, the implied score for the matchup is Hokies 28, Demon Deacons 22.
• The Hokies have a 69.6% chance to claim victory in this meeting per the moneyline's implied probability. The Demon Deacons hold a 34.6% implied probability.
• Virginia Tech has covered just once in five matchups with a spread this season.
• Wake Forest has won two games against the spread this year.

Virginia Tech vs. Wake Forest: 2025 Stats Comparison

Virginia Tech 2025 Key Players

Wake Forest 2025 Key Players

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Virginia Tech Hokies

Wake Forest Demon Deacons

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