USC vs. UCLA Prediction, Odds, Picks - November 29, 2025

Updated Nov. 29, 2025 3:04 p.m. ET

Data Skrive

Big Ten foes square off when the No. 19 USC Trojans (8-3) host the UCLA Bruins (3-8) on Saturday, November 29, 2025 at Los Angeles Memorial Coliseum. USC is favored by 21.5 points. The contest has a point total set at 58.5.

The Trojans' last game was versus the Oregon Ducks, and they lost by a score of 42-27. Last time out, the Bruins fell to the Washington Huskies, with 48-14 being the final score.

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USC vs. UCLA Game Information & Odds

When: Saturday, November 29, 2025 at 7:30 p.m. ET
Location: Los Angeles Memorial Coliseum in Los Angeles, California
TV: NBC
Live Box Score on FOX Sports

USC vs UCLA Betting Information updated as of November 29, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
USC	-21.5 (-112)	-2000	+1013	58.5	-111	-109

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USC vs. UCLA Prediction

Pick ATS: USC (-21.5)
Pick OU: Under (58.5)
Prediction: USC 40, UCLA 16

Predictions are made by the Data Skrive betting model.

Learn more about the USC Trojans vs. the UCLA Bruins game on FOX Sports!

USC vs. UCLA Betting Insights

Based on the spread and over/under, the implied score for the game is Trojans 40, Bruins 18.
The Trojans have a 95.2% chance to claim victory in this meeting based on the moneyline's implied probability. The Bruins have a 9.0% implied probability.
USC has covered five times in 11 chances against the spread this season.
UCLA has put together a 3-8-0 ATS record so far this year.

USC vs. UCLA: Head-to-Head

USC and UCLA have been evenly matched over their last four meetings, sharing the same 2-2 record.
In their last four matchups, each team has covered two times with those contests outpacing the total on two occasions.
Over their last four head-to-head contests, UCLA has put up 158 points, while USC has posted 120.

USC vs. UCLA: 2025 Stats Comparison

	USC	UCLA
Off. Points per Game (Rank)	37.2 (16)	18.9 (125)
Def. Points per Game (Rank)	23.5 (51)	33.8 (123)
Turnovers Allowed (Rank)	14 (67)	13 (51)
Turnovers Forced (Rank)	17 (35)	10 (110)

USC 2025 Key Players

Name	Position	Stats
Jayden Maiava	QB	3,174 YDS (65.7%) / 21 TD / 8 INT 140 RUSH YDS / 6 RUSH TD / 12.7 RUSH YPG
Makai Lemon	WR	78 REC / 1,124 YDS / 10 TD / 102.2 YPG
King Miller	RB	749 YDS / 5 TD / 83.2 YPG / 6.6 YPC
Ja'Kobi Lane	WR	46 REC / 693 YDS / 4 TD / 69.3 YPG
Eric Gentry	LB	41 TKL / 4 TFL / 3 SACK
Bishop Fitzgerald	DB	31 TKL / 2 TFL / 1 SACK / 5 INT
Anthony Lucas	DL	27 TKL / 3 TFL / 3 SACK
Kameryn Fountain	DL	17 TKL / 5 TFL / 3.5 SACK

UCLA 2025 Key Players

Name	Position	Stats
Nico Iamaleava	QB	1,728 YDS (63.5%) / 12 TD / 7 INT 490 RUSH YDS / 4 RUSH TD / 44.5 RUSH YPG
Kwazi Gilmer	WR	40 REC / 462 YDS / 3 TD / 42 YPG
Jalen Berger	RB	307 YDS / 2 TD / 27.9 YPG / 4.1 YPC 10 REC / 70 REC YDS / 2 REC TD / 11.7 REC YPG
Anthony Woods	RB	266 YDS / 0 TD / 26.6 YPG / 4.6 YPC 19 REC / 184 REC YDS / 2 REC TD / 23 REC YPG
JonJon Vaughns	LB	89 TKL / 4 TFL
Key Lawrence	DB	60 TKL / 4 TFL / 1 INT / 1 PD
Isaiah Chisom	LB	72 TKL / 2 TFL
Cole Martin	DB	55 TKL / 3 TFL / 1 INT / 1 PD