SMU vs. Wake Forest Prediction, Odds, Picks - October 25, 2025

Updated Oct. 25, 2025 9:04 a.m. ET

Data Skrive

The SMU Mustangs (5-2) are 3.5-point favorites when they visit the Wake Forest Demon Deacons (4-2) in an ACC matchup on Saturday, October 25, 2025 at Allegacy Federal Credit Union Stadium. The over/under is set at 53.5 points for the outing.

In their most recent game, the Mustangs won versus the Clemson Tigers, 35-24. The Demon Deacons won against the Oregon State Beavers in their last game, 39-14.

Keep up with college football all season on FOX Sports.

SMU vs. Wake Forest Game Information & Odds

When: Saturday, October 25, 2025 at 12 p.m. ET
Location: Allegacy Federal Credit Union Stadium in Winston-Salem, North Carolina
TV: The CW
Live Box Score on FOX Sports

SMU vs Wake Forest Betting Information updated as of October 25, 2025, 7:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
SMU	-3.5 (-105)	-166	+140	53.5	-110	-110

SMU vs. Wake Forest Prediction

Pick ATS: Wake Forest (+3.5)
Pick OU: Under (53.5)
Prediction: Wake Forest 27, SMU 26

Predictions are made by the Data Skrive betting model.

Learn more about the SMU Mustangs vs. the Wake Forest Demon Deacons game on FOX Sports!

SMU vs. Wake Forest Betting Insights

Per the spread and over/under, the implied score for the matchup is Mustangs 28, Demon Deacons 25.
The Mustangs have a 62.4% chance to win this contest per the moneyline's implied probability. The Demon Deacons hold a 41.7% implied probability.
SMU has won two games against the spread this season.
Wake Forest has compiled a 4-2-0 record against the spread this year.

SMU vs. Wake Forest: 2025 Stats Comparison

	SMU	Wake Forest
Off. Points per Game (Rank)	34.1 (35)	29 (92)
Def. Points per Game (Rank)	22.6 (53)	20 (18)
Turnovers Allowed (Rank)	10 (90)	6 (21)
Turnovers Forced (Rank)	15 (7)	6 (99)

SMU 2025 Key Players

Name	Position	Stats
Kevin Jennings	QB	1,948 YDS (68.4%) / 17 TD / 7 INT 26 RUSH YDS / 1 RUSH TD / 3.7 RUSH YPG
Tomarion Harden	RB	430 YDS / 5 TD / 61.4 YPG / 4.5 YPC 7 REC / 34 REC YDS / 0 REC TD / 11.3 REC YPG
Chris Johnson Jr.	RB	285 YDS / 3 TD / 47.5 YPG / 8.4 YPC 12 REC / 162 REC YDS / 1 REC TD / 27 REC YPG
Romello Brinson	WR	34 REC / 502 YDS / 3 TD / 71.7 YPG
Cam Robertson	DL	31 TKL / 5 TFL / 5 SACK
Ahmaad Moses	DB	43 TKL / 3 TFL / 1 SACK / 2 INT
Isaiah Smith	DL	19 TKL / 5 TFL / 4 SACK
Jeffrey M'ba	DL	17 TKL / 5 TFL / 5 SACK

Wake Forest 2025 Key Players

Name	Position	Stats
Demond Claiborne	RB	539 YDS / 8 TD / 89.8 YPG / 7.8 YPC 16 REC / 73 REC YDS / 0 REC TD / 14.6 REC YPG
Robby Ashford	QB	1,172 YDS (59.9%) / 2 TD / 4 INT 233 RUSH YDS / 4 RUSH TD / 46.6 RUSH YPG
Chris Barnes	WR	23 REC / 410 YDS / 3 TD / 68.3 YPG
Deshawn Purdie	QB	326 YDS (51.4%) / 5 TD / 0 INT
Langston Hardy	DL	32 TKL / 5 TFL / 4.5 SACK
Nick Andersen	DB	51 TKL / 1 TFL
Dylan Hazen	LB	34 TKL / 3 TFL
Nuer Gatkuoth	DL	24 TKL / 3 TFL / 2 SACK / 1 INT