Pittsburgh vs. Stanford Prediction, Odds, Picks - November 1, 2025

Updated Nov. 1, 2025 3:04 p.m. ET

FOX Sports

Oddsmakers heavily favor the Pittsburgh Panthers (6-2) when they visit the Stanford Cardinal (3-5) on Saturday, November 1, 2025 in a matchup between ACC foes at Stanford Stadium. Pittsburgh is favored by two touchdowns. The total for this matchup has been set at 51.5 points.

The Panthers won against the North Carolina State Wolfpack in their last game, 53-34. Last time out, the Cardinal fell to the Miami (FL) Hurricanes, with 42-7 being the final score.

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Pittsburgh vs. Stanford Game Information & Odds

When: Saturday, November 1, 2025 at 3:30 p.m. ET
Location: Stanford Stadium in Stanford, California
TV: ACC Network
Live Box Score on FOX Sports

Pittsburgh vs Stanford Betting Information updated as of November 1, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Pittsburgh	-14 (-110)	-602	+430	51.5	-111	-109

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Pittsburgh vs. Stanford Prediction

Pick ATS: Pittsburgh (-14)
Pick OU: Over (51.5)
Prediction: Pittsburgh 35, Stanford 19

Predictions are made by the Data Skrive betting model.

Learn more about the Pittsburgh Panthers vs. the Stanford Cardinal game on FOX Sports!

Pittsburgh vs. Stanford Betting Insights

Per the spread and over/under, the implied score for the tilt is Panthers 33, Cardinal 19.
The Panthers have an 85.8% chance to collect the win in this meeting per the moneyline's implied probability. The Cardinal hold an 18.9% implied probability.
Pittsburgh has covered six times in eight games with a spread this season.
Stanford has a record of just 2-6-0 against the spread this year.

Pittsburgh vs. Stanford: 2025 Stats Comparison

	Pittsburgh	Stanford
Off. Points per Game (Rank)	40.3 (8)	17.5 (126)
Def. Points per Game (Rank)	22 (54)	29.5 (101)
Turnovers Allowed (Rank)	12 (100)	11 (89)
Turnovers Forced (Rank)	12 (32)	5 (123)

Pittsburgh 2025 Key Players

Name	Position	Stats
Mason Heintschel	QB	1,246 YDS (65.1%) / 9 TD / 3 INT 122 RUSH YDS / 1 RUSH TD / 30.5 RUSH YPG
Eli Holstein	QB	1,058 YDS (62.2%) / 11 TD / 6 INT 87 RUSH YDS / 1 RUSH TD / 14.5 RUSH YPG
Raphael Williams	WR	33 REC / 528 YDS / 5 TD / 66 YPG
Desmond Reid	RB	266 YDS / 2 TD / 44.3 YPG / 4.8 YPC 17 REC / 254 REC YDS / 2 REC TD / 50.8 REC YPG
Kyle Louis	LB	40 TKL / 5 TFL / 2 SACK / 1 INT
Rasheem Biles	LB	51 TKL / 5 TFL / 2 SACK / 1 INT
Braylan Lovelace	LB	51 TKL / 3 TFL / 1 INT / 1 PD
Kavir Bains-Marquez	DB	36 TKL / 1 TFL / 1 INT / 1 PD

Stanford 2025 Key Players

Name	Position	Stats
Micah Ford	RB	425 YDS / 3 TD / 60.7 YPG / 4.3 YPC 8 REC / 77 REC YDS / 0 REC TD / 15.4 REC YPG
CJ Williams	WR	40 REC / 476 YDS / 2 TD / 59.5 YPG
Ben Gulbranson	QB	1,585 YDS (57%) / 8 TD / 7 INT
Cole Tabb	RB	365 YDS / 2 TD / 52.1 YPG / 4.2 YPC
Matt Rose	LB	58 TKL / 4 TFL / 1 SACK
Clay Patterson	DL	15 TKL / 2 TFL / 3 SACK
Scotty Edwards	DB	25 TKL / 3 TFL / 2 SACK
Zach Johnson	LB	13 TKL / 3 TFL / 2 SACK