North Texas vs. South Alabama Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 9:05 a.m. ET

Data Skrive

Two of the nation's toughest passing defenses meet when the North Texas Mean Green (4-0) take college football's 10th-ranked pass defense into a matchup with the South Alabama Jaguars (1-3), who have the No. 17 passing defense, on Saturday, September 27, 2025. The Mean Green are massive, 12.5-point favorites. An over/under of 63.5 is set in the contest.

The Mean Green beat the Army Black Knights, 45-38, in their most recent contest. Against the Coastal Carolina Chanticleers in their last game, the Jaguars lost 38-20.

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North Texas vs. South Alabama Game Information & Odds

When: Saturday, September 27, 2025 at 12 p.m. ET
Location: DATCU Stadium in Denton, Texas
TV: ESPNU
Live Box Score on FOX Sports

North Texas vs South Alabama Betting Information updated as of September 27, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
North Texas	-12.5 (-110)	-493	+368	63.5	-108	-112

North Texas vs. South Alabama Prediction

Pick ATS: North Texas (-12.5)
Pick OU: Over (63.5)
Prediction: North Texas 47, South Alabama 16

Predictions are made by the Data Skrive betting model.

Learn more about the North Texas Mean Green vs. the South Alabama Jaguars game on FOX Sports!

North Texas vs. South Alabama Betting Insights

Per the spread and over/under, the implied score for the game is Mean Green 38, Jaguars 26.
The Mean Green have an 83.1% chance to claim victory in this meeting based on the moneyline's implied probability. The Jaguars have a 21.4% implied probability.
North Texas has covered three times in four chances against the spread this season.
South Alabama has covered twice in four matchups with a spread this season.

North Texas vs. South Alabama: 2025 Stats Comparison

	North Texas	South Alabama
Off. Points per Game (Rank)	47 (9)	26 (80)
Def. Points per Game (Rank)	19.5 (55)	30.8 (121)
Turnovers Allowed (Rank)	1 (5)	8 (123)
Turnovers Forced (Rank)	10 (1)	5 (50)

North Texas 2025 Key Players

Name	Position	Stats
Drew Mestemaker	QB	1,013 YDS (70.8%) / 10 TD / 0 INT 69 RUSH YDS / 1 RUSH TD / 17.3 RUSH YPG
Caleb Hawkins	RB	167 YDS / 5 TD / 55.7 YPG / 6.4 YPC 5 REC / 42 REC YDS / 0 REC TD / 14 REC YPG
Makenzie McGill	RB	271 YDS / 4 TD / 67.8 YPG / 5.4 YPC
Wyatt Young	WR	12 REC / 179 YDS / 3 TD / 44.8 YPG
Ethan Wesloski	LB	15 TKL / 3 TFL / 1.5 SACK
Shane Whitter	LB	23 TKL / 1 TFL / 1 INT / 1 PD
Trey Fields	LB	18 TKL / 2 TFL / 1 INT / 1 PD
Ethan Day	DL	12 TKL / 2 TFL / 2 SACK

South Alabama 2025 Key Players

Name	Position	Stats
Kentrel Bullock	RB	364 YDS / 4 TD / 91 YPG / 4.8 YPC
Devin Voisin	WR	27 REC / 360 YDS / 4 TD / 90 YPG
Bishop Davenport	QB	764 YDS (69%) / 6 TD / 3 INT 56 RUSH YDS / 1 RUSH TD / 14 RUSH YPG
Anthony Eager	WR	16 REC / 135 YDS / 1 TD / 33.8 YPG
Wesley Miller	DB	13 TKL / 0 TFL / 1 INT / 1 PD
Ty Goodwill	DB	14 TKL / 2 TFL
Tirrell Johnson Jr.	LB	8 TKL / 4 TFL / 1 SACK
Christopher Wallace Jr.	DB	8 TKL / 2 TFL