NC State vs. Virginia Tech Prediction, Odds, Picks - September 27, 2025

Updated Sep. 27, 2025 3:04 p.m. ET

FOX Sports

Oddsmakers heavily favor the NC State Wolfpack (3-1) when they host the Virginia Tech Hokies (1-3) on Saturday, September 27, 2025 in a matchup between ACC rivals at Wayne Day Family Field at Carter-Finley Stadium. NC State is favored by 10 points. The contest has a point total of 57.5.

Facing the Duke Blue Devils in their last contest, the Wolfpack lost 45-33. In their most recent game, the Hokies won against the Wofford Terriers, 38-6.

Keep up with college football all season on FOX Sports.

NC State vs. Virginia Tech Game Information & Odds

When: Saturday, September 27, 2025 at 7 p.m. ET
Location: Wayne Day Family Field at Carter-Finley Stadium in Raleigh, North Carolina
TV: The CW
Live Box Score on FOX Sports

NC State vs Virginia Tech Betting Information updated as of September 27, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
NC State	-10 (-110)	-366	+284	57.5	-111	-109

NC State vs. Virginia Tech Prediction

Pick ATS: NC State (-10)
Pick OU: Over (57.5)
Prediction: NC State 38, Virginia Tech 21

Predictions are made by the Data Skrive betting model.

Learn more about the NC State Wolfpack vs. the Virginia Tech Hokies game on FOX Sports!

NC State vs. Virginia Tech Betting Insights

Per the spread and over/under, the implied score for the matchup is Wolfpack 34, Hokies 24.
The Wolfpack have a 78.5% chance to win this meeting based on the moneyline's implied probability. The Hokies have a 26.0% implied probability.
NC State has a record of 2-2-0 against the spread this season.
Virginia Tech has compiled a 0-4-0 record against the spread this year.

NC State vs. Virginia Tech: Head-to-Head

In their last two head-to-head meetings, NC State has beaten Virginia Tech two times.
The two teams went over the total both times while sharing an even 1-1 record in their meetings against the spread.
Virginia Tech has been outscored by 8 points in its last two tilts versus NC State.

NC State vs. Virginia Tech: 2025 Stats Comparison

	NC State	Virginia Tech
Off. Points per Game (Rank)	31.5 (51)	23.8 (88)
Def. Points per Game (Rank)	29.3 (115)	29.8 (119)
Turnovers Allowed (Rank)	5 (74)	7 (117)
Turnovers Forced (Rank)	3 (96)	4 (75)

NC State 2025 Key Players

Name	Position	Stats
CJ Bailey	QB	1,083 YDS (71.9%) / 7 TD / 4 INT 93 RUSH YDS / 3 RUSH TD / 23.3 RUSH YPG
Daylan Smothers	RB	503 YDS / 4 TD / 125.8 YPG / 6.3 YPC 15 REC / 83 REC YDS / 0 REC TD / 20.8 REC YPG
Terrell Anderson	WR	15 REC / 273 YDS / 2 TD / 68.3 YPG
Justin Joly	TE	18 REC / 153 YDS / 2 TD / 38.3 YPG
Caden Fordham	LB	36 TKL / 2 TFL / 1.5 SACK
Sean Brown	LB	38 TKL / 3 TFL
Brody Barnhardt	DB	20 TKL / 0 TFL
Cian Slone	LB	15 TKL / 1 TFL / 1 INT / 1 PD

Virginia Tech 2025 Key Players

Name	Position	Stats
Kyron Drones	QB	928 YDS (63%) / 6 TD / 3 INT 144 RUSH YDS / 4 RUSH TD / 36 RUSH YPG
Donavon Greene	WR	10 REC / 203 YDS / 2 TD / 50.8 YPG
Ayden Greene	WR	12 REC / 200 YDS / 1 TD / 50 YPG
Marcellous Hawkins	RB	187 YDS / 0 TD / 46.8 YPG / 4.7 YPC 8 REC / 49 REC YDS / 0 REC TD / 12.3 REC YPG
Michael Short	LB	20 TKL / 2 TFL / 1 SACK
Kemari Copeland	DL	15 TKL / 0 TFL / 1 SACK / 1 INT
Kelvin Gilliam	DL	10 TKL / 1 TFL / 2 SACK
Quentin Reddish	DB	11 TKL / 0 TFL / 1 INT / 1 PD