Miami (FL) vs. Louisville Prediction, Odds, Picks - October 17, 2025

Updated Oct. 17, 2025 3:04 p.m. ET

Data Skrive

The No. 2 Miami Hurricanes (5-0) are 12.5-point favorites when they host the Louisville Cardinals (4-1) in an ACC matchup on Friday, October 17, 2025 at Hard Rock Stadium. The contest has a point total of 49.5.

The Hurricanes' most recent contest was against the Florida State Seminoles, and they won by a score of 28-22. Last time out, the Cardinals fell to the Virginia Cavaliers, with 30-27 being the final score.

Keep up with college football all season on FOX Sports.

Miami (FL) vs. Louisville Game Information & Odds

When: Friday, October 17, 2025 at 7 p.m. ET
Location: Hard Rock Stadium in Miami Gardens, Florida
TV: ESPN
Live Box Score on FOX Sports

Miami (FL) vs Louisville Betting Information updated as of October 17, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Miami (FL)	-12.5 (-108)	-442	+343	49.5	-111	-109

Miami (FL) vs. Louisville Prediction

Pick ATS: Miami (FL) (-12.5)
Pick OU: Over (49.5)
Prediction: Miami (FL) 38, Louisville 13

Predictions are made by the Data Skrive betting model.

Learn more about the Miami Hurricanes vs. the Louisville Cardinals game on FOX Sports!

Miami (FL) vs. Louisville Betting Insights

Per the spread and over/under, the implied score for the tilt is Hurricanes 31, Cardinals 18.
The Hurricanes have an 81.5% chance to win this game per the moneyline's implied probability. The Cardinals have a 22.6% implied probability.
Miami (FL) has covered four times in five matchups with a spread this season.
Louisville has a record of just 1-4-0 against the spread this year.

Miami (FL) vs. Louisville: Head-to-Head

The last two times Louisville and Miami (FL) have played, the two teams share the same 1-1 record.
The two teams went over the point total both times while sharing an even 1-1 record in their games against the spread.
Louisville has put up 83 points in its last two contests against Miami (FL), mirroring the Hurricanes' offensive output (83 points) in those games.

Miami (FL) vs. Louisville: 2025 Stats Comparison

	Miami (FL)	Louisville
Off. Points per Game (Rank)	35 (66)	36 (62)
Def. Points per Game (Rank)	13.6 (4)	21 (22)
Turnovers Allowed (Rank)	3 (6)	8 (77)
Turnovers Forced (Rank)	9 (42)	9 (42)

Miami (FL) 2025 Key Players

Name	Position	Stats
Carson Beck	QB	1,213 YDS (72.9%) / 11 TD / 3 INT 18 RUSH YDS / 1 RUSH TD / 4.5 RUSH YPG
Mark Fletcher	RB	428 YDS / 5 TD / 85.6 YPG / 5.5 YPC 5 REC / 53 REC YDS / 0 REC TD / 10.6 REC YPG
CharMar Brown	RB	210 YDS / 4 TD / 42 YPG / 3.7 YPC 8 REC / 75 REC YDS / 1 REC TD / 18.8 REC YPG
CJ Daniels	WR	23 REC / 269 YDS / 5 TD / 53.8 YPG
Jakobe Thomas	DB	17 TKL / 3 TFL / 2 SACK / 1 INT
Akheem Mesidor	DL	21 TKL / 3 TFL / 3.5 SACK
Rueben Bain Jr.	DL	23 TKL / 1 TFL / 2 SACK / 1 INT
Wesley Bissainthe	LB	20 TKL / 0 TFL

Louisville 2025 Key Players

Name	Position	Stats
Miller Moss	QB	1,358 YDS (67%) / 7 TD / 4 INT -78 RUSH YDS / 3 RUSH TD / -15.6 RUSH YPG
Chris Bell	WR	35 REC / 502 YDS / 4 TD / 100.4 YPG
Isaac Brown	RB	334 YDS / 3 TD / 66.8 YPG / 7.3 YPC 9 REC / 36 REC YDS / 0 REC TD / 12 REC YPG
Caullin Lacy	WR	27 REC / 287 YDS / 0 TD / 57.4 YPG
Clev Lubin	DL	24 TKL / 2 TFL / 3.5 SACK
Antonio Watts	LB	19 TKL / 3 TFL / 2.5 SACK / 2 INT
TJ Quinn	LB	29 TKL / 2 TFL / 1 SACK / 2 INT
D'Angelo Hutchinson	DB	32 TKL / 1 TFL / 1 INT / 1 PD