LSU vs. Florida Prediction, Odds, Picks - September 13, 2025

Updated Sep. 13, 2025 3:04 p.m. ET

Data Skrive

The No. 3 LSU Tigers (2-0) are favored by 6.5 points when they play host to the Florida Gators (1-1) in SEC action on Saturday, September 13, 2025 at Tiger Stadium. The contest has a point total set at 47.5.

The Tigers beat the Louisiana Tech Bulldogs, 23-7, in their last contest. Last time out, the Gators fell to the South Florida Bulls, with 18-16 being the final score.

Keep up with college football all season on FOX Sports.

LSU vs. Florida Game Information & Odds

When: Saturday, September 13, 2025 at 7:30 p.m. ET
Location: Tiger Stadium in Baton Rouge, Louisiana
TV: ABC
Live Box Score on FOX Sports

LSU vs Florida Betting Information updated as of September 13, 2025, 1:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
LSU	-6.5 (-110)	-250	+203	47.5	-110	-110

LSU vs. Florida Prediction

Pick ATS: Florida (+6.5)
Pick OU: Under (47.5)
Prediction: LSU 18, Florida 13

Predictions are made by the Data Skrive betting model.

Learn more about the LSU Tigers vs. the Florida Gators game on FOX Sports!

LSU vs. Florida Betting Insights

Based on the spread and over/under, the implied score for the tilt is Tigers 27, Gators 20.
The Tigers have a 71.4% chance to claim victory in this meeting based on the moneyline's implied probability. The Gators have a 33.0% implied probability.
LSU has covered once in two games with a spread this season.
Florida has covered once in two chances against the spread this year.

LSU vs. Florida: Head-to-Head

LSU has a 3-1 record against Florida in their last four matchups.
The Tigers carry a 3-1 record ATS in those games, while the two teams have gone over the total on three occasions.
Over their last four head-to-head matchups, LSU has put up 162 points, while Florida has accumulated 139.

LSU vs. Florida: 2025 Stats Comparison

	LSU	Florida
Off. Points per Game (Rank)	20 (108)	35.5 (53)
Def. Points per Game (Rank)	8.5 (13)	9 (19)
Turnovers Allowed (Rank)	3 (83)	1 (22)
Turnovers Forced (Rank)	1 (96)	2 (64)

LSU 2025 Key Players

Name	Position	Stats
Caden Durham	RB	103 YDS / 2 TD / 51.5 YPG / 3.4 YPC 5 REC / 32 REC YDS / 0 REC TD / 16 REC YPG
Garrett Nussmeier	QB	467 YDS (68.4%) / 2 TD / 1 INT
Aaron Anderson	WR	14 REC / 172 YDS / 0 TD / 86 YPG
Zavion Thomas	WR	5 REC / 54 YDS / 0 TD / 27 YPG
West Weeks	LB	13 TKL / 0 TFL / 0.5 SACK
PJ Woodland	DB	7 TKL / 1 TFL / 1 SACK
Harold Perkins	LB	7 TKL / 1 TFL / 1 SACK
Whit Weeks	LB	7 TKL / 0 TFL / 0.5 SACK

Florida 2025 Key Players

Name	Position	Stats
DJ Lagway	QB	342 YDS (74.5%) / 4 TD / 1 INT
Jadan Baugh	RB	197 YDS / 1 TD / 98.5 YPG / 7.3 YPC
Eugene Wilson III	WR	12 REC / 56 YDS / 2 TD / 28 YPG
Tramell Jones Jr.	QB	131 YDS (66.7%) / 2 TD / 0 INT 14 RUSH YDS / 0 RUSH TD / 14 RUSH YPG
Myles Graham	LB	12 TKL / 1 TFL
Bryce Thornton	DB	6 TKL / 0 TFL
Jaden Robinson	LB	9 TKL / 1 TFL
Tyreak Sapp	DL	5 TKL / 2 TFL / 1 SACK