Louisville vs. Cal Prediction, Odds, Picks - November 8, 2025

Updated Nov. 8, 2025 3:04 p.m. ET

Data Skrive

The No. 14 Louisville Cardinals (7-1) are 18.5-point favorites when they host the California Golden Bears (5-4) in an ACC matchup on Saturday, November 8, 2025 at L&N Federal Credit Union Stadium. The over/under is set at 49.5 points for the game.

The Cardinals beat the Virginia Tech Hokies, 28-16, in their last contest. Against the Virginia Cavaliers in their most recent contest, the Golden Bears lost 31-21.

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Louisville vs. Cal Game Information & Odds

When: Saturday, November 8, 2025 at 7 p.m. ET
Location: L&N Federal Credit Union Stadium in Louisville, Kentucky
TV: ESPN2
Live Box Score on FOX Sports

Louisville vs Cal Betting Information updated as of November 8, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisville	-18.5 (-105)	-1053	+680	49.5	-108	-115

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Louisville vs. Cal Prediction

Pick ATS: Louisville (-18.5)
Pick OU: Over (49.5)
Prediction: Louisville 37, Cal 15

Predictions are made by the Data Skrive betting model.

Learn more about the Louisville Cardinals vs. the California Golden Bears game on FOX Sports!

Louisville vs. Cal Betting Insights

Per the spread and over/under, the implied score for the game is Cardinals 34, Golden Bears 16.
The Cardinals have a 91.3% chance to collect the win in this meeting based on the moneyline's implied probability. The Golden Bears have a 12.8% implied probability.
Louisville has won three games against the spread this season, while failing to cover five times.
Cal has put together a 3-6-0 record against the spread this season.

Louisville vs. Cal: 2025 Stats Comparison

	Louisville	Cal
Off. Points per Game (Rank)	33.8 (50)	24.6 (85)
Def. Points per Game (Rank)	20.8 (26)	25.1 (84)
Turnovers Allowed (Rank)	13 (99)	12 (81)
Turnovers Forced (Rank)	16 (17)	11 (56)

Louisville 2025 Key Players

Name	Position	Stats
Miller Moss	QB	1,929 YDS (65.3%) / 11 TD / 6 INT -66 RUSH YDS / 6 RUSH TD / -8.3 RUSH YPG
Chris Bell	WR	56 REC / 743 YDS / 6 TD / 92.9 YPG
Isaac Brown	RB	782 YDS / 5 TD / 97.8 YPG / 8.6 YPC 11 REC / 42 REC YDS / 0 REC TD / 10.5 REC YPG
Keyjuan Brown	RB	321 YDS / 6 TD / 45.9 YPG / 6.2 YPC 8 REC / 99 REC YDS / 0 REC TD / 16.5 REC YPG
TJ Quinn	LB	57 TKL / 3 TFL / 1 SACK / 2 INT
Antonio Watts	LB	30 TKL / 4 TFL / 2.5 SACK / 3 INT
D'Angelo Hutchinson	DB	54 TKL / 2 TFL / 1 INT / 1 PD
Clev Lubin	DL	32 TKL / 2 TFL / 3.5 SACK

Cal 2025 Key Players

Name	Position	Stats
Kendrick Raphael	RB	621 YDS / 10 TD / 69 YPG / 4.2 YPC 17 REC / 129 REC YDS / 1 REC TD / 16.1 REC YPG
Jaron-Keawe Sagapolutele	QB	2,187 YDS (61.1%) / 11 TD / 9 INT -96 RUSH YDS / 2 RUSH TD / -10.7 RUSH YPG
Jacob De Jesus	WR	56 REC / 533 YDS / 3 TD / 59.2 YPG
Mason Mini	TE	34 REC / 382 YDS / 4 TD / 42.4 YPG
Cade Uluave	LB	66 TKL / 9 TFL / 3 SACK
Luke Ferrelli	LB	41 TKL / 3 TFL / 1 SACK / 1 INT
Dru Polidore	DB	36 TKL / 2 TFL
Cam Sidney	DB	27 TKL / 3 TFL / 1 SACK / 1 INT