Louisville vs. Bowling Green Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 9:04 a.m. ET

FOX Sports

The Bowling Green Falcons (2-1) will attempt to defy oddsmakers when they square off against the Louisville Cardinals (2-0) on Saturday, September 20, 2025 as a heavy 26.5-point underdog. This game has an over/under of 51 points.

In their last game, the Cardinals won against the James Madison Dukes, 28-14. Last time out, the Falcons defeated the Liberty Flames, with 23-13 being the final score.

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Louisville vs. Bowling Green Game Information & Odds

When: Saturday, September 20, 2025 at 12 p.m. ET
Location: L&N Federal Credit Union Stadium in Louisville, Kentucky
TV: ACC Network
Live Box Score on FOX Sports

Louisville vs Bowling Green Betting Information updated as of September 20, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisville	-26.5 (-109)	-4545	+1570	51	-110	-110

Louisville vs. Bowling Green Prediction

Pick ATS: Bowling Green (+26.5)
Pick OU: Under (51)
Prediction: Louisville 28, Bowling Green 16

Predictions are made by the Data Skrive betting model.

Learn more about the Louisville Cardinals vs. the Bowling Green Falcons game on FOX Sports!

Louisville vs. Bowling Green Betting Insights

Per the spread and over/under, the implied score for the tilt is Cardinals 39, Falcons 12.
The Cardinals have a 97.8% chance to collect the win in this contest based on the moneyline's implied probability. The Falcons hold a 6.0% implied probability.
Louisville is winless against the spread this season (0-2-0).
Bowling Green has won two games against the spread this season.

Louisville vs. Bowling Green: 2025 Stats Comparison

	Louisville	Bowling Green
Off. Points per Game (Rank)	39.5 (81)	23 (94)
Def. Points per Game (Rank)	15.5 (17)	18 (50)
Turnovers Allowed (Rank)	4 (78)	0 (1)
Turnovers Forced (Rank)	2 (96)	5 (26)

Louisville 2025 Key Players

Name	Position	Stats
Isaac Brown	RB	230 YDS / 3 TD / 115 YPG / 12.8 YPC 3 REC / 14 REC YDS / 0 REC TD / 14 REC YPG
Miller Moss	QB	374 YDS (62.5%) / 2 TD / 2 INT 0 RUSH YDS / 1 RUSH TD / 0 RUSH YPG
Chris Bell	WR	9 REC / 146 YDS / 1 TD / 73 YPG
Caullin Lacy	WR	6 REC / 74 YDS / 0 TD / 37 YPG
Clev Lubin	DL	14 TKL / 2 TFL / 3.5 SACK
TJ Quinn	LB	13 TKL / 1 TFL / 1 SACK
Adonijah Green	DL	7 TKL / 1 TFL / 1 SACK
Wesley Bailey	DL	10 TKL / 0 TFL / 1 SACK

Bowling Green 2025 Key Players

Name	Position	Stats
Drew Pyne	QB	529 YDS (67.1%) / 2 TD / 0 INT
Kaderris Roberts	RB	152 YDS / 0 TD / 50.7 YPG / 5.6 YPC 10 REC / 55 REC YDS / 0 REC TD / 18.3 REC YPG
Jyrin Johnson	TE	10 REC / 138 YDS / 1 TD / 46 YPG
Cameron Pettaway	RB	124 YDS / 0 TD / 41.3 YPG / 4.8 YPC
Dorian Pringle	LB	17 TKL / 3 TFL / 0.5 SACK / 1 INT
Kal-El Pascal	DB	13 TKL / 0 TFL / 1 INT / 1 PD
Gideon Lampron	LB	15 TKL / 2 TFL / 0.5 SACK
Mark Cannon Jr.	DB	11 TKL / 3 TFL / 1 SACK