Louisiana Tech vs. Southern Miss Prediction, Odds, Picks - September 20, 2025

Updated Sep. 20, 2025 3:04 p.m. ET

Data Skrive

The Southern Miss Golden Eagles (2-1) are 3-point underdogs heading into their matchup on Saturday, September 20, 2025 against the Louisiana Tech Bulldogs (2-1). The over/under is 50.5 for the game.

The Bulldogs won versus the New Mexico State Aggies in their most recent game, 49-14. The Golden Eagles won versus the Appalachian State Mountaineers in their most recent game, 38-22.

Keep up with college football all season on FOX Sports.

Louisiana Tech vs. Southern Miss Game Information & Odds

When: Saturday, September 20, 2025 at 7:30 p.m. ET
Location: Joe Aillet Stadium in Ruston, Louisiana
TV: ESPN+
Live Box Score on FOX Sports

Louisiana Tech vs Southern Miss Betting Information updated as of September 20, 2025, 12:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Louisiana Tech	-3 (-111)	-157	+132	50.5	-114	-106

Louisiana Tech vs. Southern Miss Prediction

Pick ATS: Southern Miss (+3)
Pick OU: Over (50.5)
Prediction: Louisiana Tech 26, Southern Miss 25

Predictions are made by the Data Skrive betting model.

Learn more about the Louisiana Tech Bulldogs vs. the Southern Miss Golden Eagles game on FOX Sports!

Louisiana Tech vs. Southern Miss Betting Insights

Per the spread and over/under, the implied score for the matchup is Bulldogs 27, Golden Eagles 24.
The Bulldogs have a 61.1% chance to claim victory in this meeting per the moneyline's implied probability. The Golden Eagles have a 43.1% implied probability.
Louisiana Tech has won three games against the spread this season, while failing to cover zero times.
Southern Miss has a record of 2-1-0 against the spread this season.

Louisiana Tech vs. Southern Miss: 2025 Stats Comparison

	Louisiana Tech	Southern Miss
Off. Points per Game (Rank)	26.7 (79)	31 (61)
Def. Points per Game (Rank)	12.3 (26)	25.3 (91)
Turnovers Allowed (Rank)	1 (10)	2 (27)
Turnovers Forced (Rank)	7 (6)	6 (14)

Louisiana Tech 2025 Key Players

Name	Position	Stats
Blake Baker	QB	204 YDS (47.8%) / 2 TD / 0 INT 120 RUSH YDS / 1 RUSH TD / 60 RUSH YPG
Trey Kukuk	QB	227 YDS (70.7%) / 2 TD / 1 INT 106 RUSH YDS / 0 RUSH TD / 35.3 RUSH YPG
Clay Thevenin	RB	151 YDS / 1 TD / 50.3 YPG / 6.3 YPC
Omiri Wiggins	RB	80 YDS / 1 TD / 26.7 YPG / 3.3 YPC 2 REC / 18 REC YDS / 1 REC TD / 9 REC YPG
Mekhi Mason	LB	18 TKL / 3 TFL / 3 SACK
Kolbe Fields	LB	14 TKL / 2 TFL / 1.5 SACK
Sifa Leota	LB	17 TKL / 2 TFL / 0.5 SACK
Jakari Foster	DB	4 TKL / 0 TFL / 2 INT / 2 PD

Southern Miss 2025 Key Players

Name	Position	Stats
Braylon Braxton	QB	692 YDS (68.7%) / 7 TD / 2 INT 105 RUSH YDS / 0 RUSH TD / 35 RUSH YPG
Jeffery Pittman	RB	126 YDS / 2 TD / 42 YPG / 5 YPC 11 REC / 63 REC YDS / 0 REC TD / 21 REC YPG
Micah Davis	WR	8 REC / 74 YDS / 3 TD / 24.7 YPG
Robert Briggs	RB	69 YDS / 1 TD / 23 YPG / 3.8 YPC 4 REC / 24 REC YDS / 1 REC TD / 8 REC YPG
J'Mond Tapp	DL	10 TKL / 3 TFL / 3 SACK
Josh Battle	DB	12 TKL / 1 TFL / 1 SACK
Mathis Haygood	LB	7 TKL / 1 TFL / 1 SACK / 1 INT
Joshuah Moten	DB	17 TKL / 0 TFL