Liberty vs. Jacksonville State Prediction, Odds, Picks - September 6, 2025

Updated Sep. 6, 2025 9:04 a.m. ET

FOX Sports

Oddsmakers give the Liberty Flames (1-0) the edge when they visit the Jacksonville State Gamecocks (0-1) on Saturday, September 6, 2025 in a matchup between CUSA opponents at AmFirst Stadium. Liberty is favored by 6.5 points. The over/under is set at 50.5.

The Flames won versus the Maine Black Bears in their last game, 28-7. Last time around, the Gamecocks fell to the UCF Knights, with 17-10 being the final score.

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Liberty vs. Jacksonville State Game Information & Odds

When: Saturday, September 6, 2025 at 12 p.m. ET
Location: AmFirst Stadium in Jacksonville, Alabama
TV: CBS Sports Network
Live Box Score on FOX Sports

Liberty vs Jacksonville State Betting Information updated as of September 6, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Liberty	-6.5 (-112)	-244	+199	50.5	-110	-110

Liberty vs. Jacksonville State Prediction

Pick ATS: Jacksonville State (+6.5)
Pick OU: Over (50.5)
Prediction: Jacksonville State 35, Liberty 22

Predictions are made by the Data Skrive betting model.

Learn more about the Liberty Flames vs. the Jacksonville State Gamecocks game on FOX Sports!

Liberty vs. Jacksonville State Betting Insights

Per the spread and over/under, the implied score for the game is Flames 28, Gamecocks 22.
The Flames have a 70.9% chance to collect the win in this meeting based on the moneyline's implied probability. The Gamecocks hold a 33.4% implied probability.
Liberty has not won against the spread this season in one opportunities.
Jacksonville State has covered in its only game with a spread this season.

Liberty vs. Jacksonville State: Head-to-Head

Liberty and Jacksonville State have been matched up evenly over their last two meetings, sharing the same 1-1 record.
The two teams have never hit the over on the total while sharing an even 1-1 record in their meetings against the spread.
In their last two head-to-head matchups, Liberty has racked up 52 points versus Jacksonville State, while surrendering only 44 points.

Liberty vs. Jacksonville State: 2025 Stats Comparison

	Liberty	Jacksonville State
Off. Points per Game (Rank)	28 (67)	10 (120)
Def. Points per Game (Rank)	7 (20)	17 (66)
Turnovers Allowed (Rank)	0 (1)	1 (55)
Turnovers Forced (Rank)	2 (22)	1 (51)

Liberty 2025 Key Players

Name	Position	Stats
Ethan Vasko	QB	197 YDS (57.6%) / 3 TD / 0 INT 63 RUSH YDS / 1 RUSH TD / 63 RUSH YPG
Evan Dickens	RB	34 YDS / 0 TD / 34 YPG / 3.4 YPC 1 REC / 24 REC YDS / 1 REC TD / 24 REC YPG
Reese Smith	WR	6 REC / 46 YDS / 1 TD / 46 YPG
Donte Lee Jr.	WR	3 REC / 36 YDS / 1 TD / 36 YPG
CJ Bazile Jr.	DL	6 TKL / 0 TFL / 1.5 SACK
Amarian Williams	DB	5 TKL / 0 TFL / 1 INT / 1 PD
Brenton Williams	DL	2 TKL / 1 TFL / 1 SACK
Damond Harmon	DB	3 TKL / 0 TFL / 0.5 SACK

Jacksonville State 2025 Key Players

Name	Position	Stats
Cam Cook	RB	75 YDS / 0 TD / 75 YPG / 4.4 YPC 4 REC / 43 REC YDS / 0 REC TD / 43 REC YPG
Andrew Paul	RB	25 YDS / 1 TD / 25 YPG / 5 YPC 1 REC / 17 REC YDS / 0 REC TD / 17 REC YPG
Gavin Wimsatt	QB	139 YDS (51.7%) / 0 TD / 1 INT 28 RUSH YDS / 0 RUSH TD / 28 RUSH YPG
Deondre Johnson	WR	2 REC / 35 YDS / 0 TD / 35 YPG
Kalib Alexander	DB	3 TKL / 1 TFL / 1 SACK
Trevor Woods	DB	8 TKL / 0 TFL
Thaxton Gallagher	LB	4 TKL / 0 TFL
Gharin Stansbury	DL	1 TKL / 1 TFL / 1 SACK