Houston vs. Colorado Prediction, Odds, Picks - September 12, 2025

Updated Sep. 12, 2025 3:04 p.m. ET

FOX Sports

The Houston Cougars (2-0) are 4.5-point favorites when they host the Colorado Buffaloes (1-1) in a Big 12 matchup on Friday, September 12, 2025 at TDECU Stadium. A total of 45 points has been set for this matchup.

The Cougars' last game was against the Rice Owls, and they won by a score of 35-9. Last time around, the Buffaloes defeated the Delaware Blue Hens, with 31-7 being the final score.

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Houston vs. Colorado Game Information & Odds

When: Friday, September 12, 2025 at 7:30 p.m. ET
Location: TDECU Stadium in Houston, Texas
TV: ESPN
Live Box Score on FOX Sports

Houston vs Colorado Betting Information updated as of September 12, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Houston	-4.5 (-115)	-213	+176	45	-110	-110

Houston vs. Colorado Prediction

Pick ATS: Colorado (+4.5)
Pick OU: Under (45)
Prediction: Houston 23, Colorado 20

Predictions are made by the Data Skrive betting model.

Learn more about the Houston Cougars vs. the Colorado Buffaloes game on FOX Sports!

Houston vs. Colorado Betting Insights

Based on the spread and over/under, the implied score for the game is Cougars 25, Buffaloes 20.
The Cougars have a 68.1% chance to claim victory in this contest based on the moneyline's implied probability. The Buffaloes hold a 36.2% implied probability.
Houston has won two games against the spread this season.
Colorado has won one game against the spread this season.

Houston vs. Colorado: 2025 Stats Comparison

	Houston	Colorado
Off. Points per Game (Rank)	31 (60)	25.5 (83)
Def. Points per Game (Rank)	4.5 (4)	17 (58)
Turnovers Allowed (Rank)	0 (1)	0 (1)
Turnovers Forced (Rank)	4 (17)	5 (6)

Houston 2025 Key Players

Name	Position	Stats
Conner Weigman	QB	347 YDS (65.2%) / 4 TD / 0 INT 62 RUSH YDS / 1 RUSH TD / 31 RUSH YPG
Dean Connors	RB	182 YDS / 2 TD / 91 YPG / 6.5 YPC
Tanner Koziol	TE	13 REC / 115 YDS / 1 TD / 57.5 YPG
J'Marion Burnette	RB	40 YDS / 0 TD / 40 YPG / 4 YPC 1 REC / 39 REC YDS / 1 REC TD / 39 REC YPG
Brandon Mack	LB	4 TKL / 0 TFL / 1.5 SACK
Will James	DB	4 TKL / 1 TFL / 1 INT / 1 PD
Wrook Brown	DB	3 TKL / 1 TFL / 1 SACK
Eddie Walls III	DL	3 TKL / 1 TFL / 1 SACK

Colorado 2025 Key Players

Name	Position	Stats
Kaidon Salter	QB	261 YDS (68.2%) / 1 TD / 0 INT 68 RUSH YDS / 2 RUSH TD / 34 RUSH YPG
Dekalon Taylor	RB	50 YDS / 0 TD / 25 YPG / 6.3 YPC 7 REC / 87 REC YDS / 2 REC TD / 43.5 REC YPG
Sincere Brown	WR	4 REC / 120 YDS / 1 TD / 60 YPG
Micah Welch	RB	78 YDS / 1 TD / 39 YPG / 4.3 YPC
Martavius French	LB	10 TKL / 2 TFL / 1 SACK
Jeremiah Brown	LB	9 TKL / 1 TFL
D.J. McKinney	DB	8 TKL / 1 TFL / 1 INT / 1 PD
Reginald Hughes	LB	14 TKL / 0 TFL