Houston vs. Colorado Prediction, Odds, Picks - September 12, 2025

Houston vs. Colorado Prediction, Odds, Picks - September 12, 2025

Updated Sep. 12, 2025 3:04 p.m. ET
FOX Sports

The Houston Cougars (2-0) are 4.5-point favorites when they host the Colorado Buffaloes (1-1) in a Big 12 matchup on Friday, September 12, 2025 at TDECU Stadium. A total of 45 points has been set for this matchup.

The Cougars' last game was against the Rice Owls, and they won by a score of 35-9. Last time around, the Buffaloes defeated the Delaware Blue Hens, with 31-7 being the final score.

Keep up with college football all season on FOX Sports.

Houston vs. Colorado Game Information & Odds

  • When: Friday, September 12, 2025 at 7:30 p.m. ET
  • Location: TDECU Stadium in Houston, Texas
  • TV: ESPN
  • Live Box Score on FOX Sports
Houston vs Colorado Betting Information updated as of September 12, 2025, 2:45 p.m. ET.
Favorite Spread (Odds) Favorite Moneyline Underdog Moneyline Total Over Moneyline Under Moneyline
Houston -4.5 (-115) -213 +176 45 -110 -110

Houston vs. Colorado Prediction

  • Pick ATS: Colorado (+4.5)
  • Pick OU: Under (45)
  • Prediction: Houston 23, Colorado 20

Predictions are made by the Data Skrive betting model.

Learn more about the Houston Cougars vs. the Colorado Buffaloes game on FOX Sports!

Houston vs. Colorado Betting Insights

  • Based on the spread and over/under, the implied score for the game is Cougars 25, Buffaloes 20.
  • The Cougars have a 68.1% chance to claim victory in this contest based on the moneyline's implied probability. The Buffaloes hold a 36.2% implied probability.
  • Houston has won two games against the spread this season.
  • Colorado has won one game against the spread this season.

Houston vs. Colorado: 2025 Stats Comparison

Houston Colorado
Off. Points per Game (Rank) 31 (60) 25.5 (83)
Def. Points per Game (Rank) 4.5 (4) 17 (58)
Turnovers Allowed (Rank) 0 (1) 0 (1)
Turnovers Forced (Rank) 4 (17) 5 (6)

Houston 2025 Key Players

Name Position Stats
Conner Weigman QB 347 YDS (65.2%) / 4 TD / 0 INT
62 RUSH YDS / 1 RUSH TD / 31 RUSH YPG
Dean Connors RB 182 YDS / 2 TD / 91 YPG / 6.5 YPC
Tanner Koziol TE 13 REC / 115 YDS / 1 TD / 57.5 YPG
J'Marion Burnette RB 40 YDS / 0 TD / 40 YPG / 4 YPC
1 REC / 39 REC YDS / 1 REC TD / 39 REC YPG
Brandon Mack LB 4 TKL / 0 TFL / 1.5 SACK
Will James DB 4 TKL / 1 TFL / 1 INT / 1 PD
Wrook Brown DB 3 TKL / 1 TFL / 1 SACK
Eddie Walls III DL 3 TKL / 1 TFL / 1 SACK

Colorado 2025 Key Players

Name Position Stats
Kaidon Salter QB 261 YDS (68.2%) / 1 TD / 0 INT
68 RUSH YDS / 2 RUSH TD / 34 RUSH YPG
Dekalon Taylor RB 50 YDS / 0 TD / 25 YPG / 6.3 YPC
7 REC / 87 REC YDS / 2 REC TD / 43.5 REC YPG
Sincere Brown WR 4 REC / 120 YDS / 1 TD / 60 YPG
Micah Welch RB 78 YDS / 1 TD / 39 YPG / 4.3 YPC
Martavius French LB 10 TKL / 2 TFL / 1 SACK
Jeremiah Brown LB 9 TKL / 1 TFL
D.J. McKinney DB 8 TKL / 1 TFL / 1 INT / 1 PD
Reginald Hughes LB 14 TKL / 0 TFL

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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