Florida State vs. Pittsburgh Prediction, Odds, Picks - October 11, 2025

Updated Oct. 11, 2025 9:04 a.m. ET

Data Skrive

The No. 25 Florida State Seminoles (3-2) will test their second-ranked running game against the Pittsburgh Panthers (3-2), who have the No. 111 rush defense in college football, on Saturday, October 11, 2025. The Seminoles are favored by 10 points in the game. The contest's point total is 57.5.

Last time around, the Seminoles fell to the Miami (FL) Hurricanes, with 28-22 being the final score. The Panthers won against the Boston College Eagles in their last game, 48-7.

Keep up with college football all season on FOX Sports.

Florida State vs. Pittsburgh Game Information & Odds

When: Saturday, October 11, 2025 at 12 p.m. ET
Location: Bobby Bowden Field at Doak Campbell Stadium in Tallahassee, Florida
TV: ESPN
Live Box Score on FOX Sports

Florida State vs Pittsburgh Betting Information updated as of October 11, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Florida State	-10 (-110)	-380	+301	57.5	-109	-110

Florida State vs. Pittsburgh Prediction

Pick ATS: Florida State (-10)
Pick OU: Over (57.5)
Prediction: Florida State 42, Pittsburgh 19

Predictions are made by the Data Skrive betting model.

Learn more about the Florida State Seminoles vs. the Pittsburgh Panthers game on FOX Sports!

Florida State vs. Pittsburgh Betting Insights

Based on the spread and over/under, the implied score for the matchup is Seminoles 34, Panthers 24.
The Seminoles have a 79.2% chance to collect the win in this contest per the moneyline's implied probability. The Panthers hold a 24.9% implied probability.
Florida State has covered twice in four games with a spread this season.
Pittsburgh is 3-2-0 ATS this season.

Florida State vs. Pittsburgh: 2025 Stats Comparison

	Florida State	Pittsburgh
Off. Points per Game (Rank)	46.8 (11)	41 (21)
Def. Points per Game (Rank)	20.8 (38)	19.6 (33)
Turnovers Allowed (Rank)	9 (111)	8 (93)
Turnovers Forced (Rank)	6 (70)	7 (55)

Florida State 2025 Key Players

Name	Position	Stats
Thomas Castellanos	QB	1,120 YDS (60.9%) / 6 TD / 5 INT 274 RUSH YDS / 4 RUSH TD / 54.8 RUSH YPG
Gavin Sawchuk	RB	281 YDS / 6 TD / 56.2 YPG / 5.3 YPC 6 REC / 85 REC YDS / 1 REC TD / 21.3 REC YPG
Duce Robinson	WR	23 REC / 433 YDS / 3 TD / 86.6 YPG
Micahi Danzy	WR	9 REC / 197 YDS / 0 TD / 39.4 YPG
Earl Little II	DB	35 TKL / 0 TFL / 1 INT / 2 PD
Elijah Herring	LB	20 TKL / 2 TFL / 1 SACK / 1 INT
Ja'Bril Rawls	DB	25 TKL / 1 TFL / 1 INT / 1 PD
Ashlynd Barker	DB	14 TKL / 2 TFL / 2 SACK

Pittsburgh 2025 Key Players

Name	Position	Stats
Eli Holstein	QB	1,058 YDS (62.7%) / 11 TD / 5 INT 83 RUSH YDS / 1 RUSH TD / 16.6 RUSH YPG
Raphael Williams	WR	19 REC / 360 YDS / 4 TD / 72 YPG
Juelz Goff	RB	175 YDS / 3 TD / 35 YPG / 3.9 YPC 7 REC / 63 REC YDS / 0 REC TD / 15.8 REC YPG
Cataurus Hicks	WR	11 REC / 197 YDS / 3 TD / 39.4 YPG
Rasheem Biles	LB	43 TKL / 5 TFL / 2 SACK / 1 INT
Kyle Louis	LB	29 TKL / 4 TFL / 2 SACK / 1 INT
Braylan Lovelace	LB	30 TKL / 3 TFL / 1 INT / 1 PD
Cruce Brookins	DB	32 TKL / 1 TFL