East Carolina vs. UTSA Prediction, Odds, Picks - November 22, 2025

Updated Nov. 22, 2025 3:04 p.m. ET

Data Skrive

The UTSA Roadrunners (5-5) are small, 1.5-point underdogs in a home AAC matchup with the East Carolina Pirates (7-3) on Saturday, November 22, 2025 at the Alamodome. The over/under is set at 62.5 points for the outing.

Facing the Memphis Tigers in their last contest, the Pirates won 31-27. The Roadrunners' last game was against the Charlotte 49ers, and they won by a score of 28-7.

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East Carolina vs. UTSA Game Information & Odds

When: Saturday, November 22, 2025 at 3:30 p.m. ET
Location: Alamodome in San Antonio, Texas
TV: ESPN+
Live Box Score on FOX Sports

East Carolina vs UTSA Betting Information updated as of November 22, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
East Carolina	-1.5 (-110)	-119	-101	62.5	-113	-107

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East Carolina vs. UTSA Prediction

Pick ATS: East Carolina (-1.5)
Pick OU: Under (62.5)
Prediction: East Carolina 32, UTSA 25

Predictions are made by the Data Skrive betting model.

Learn more about the East Carolina Pirates vs. the UTSA Roadrunners game on FOX Sports!

East Carolina vs. UTSA Betting Insights

Per the spread and over/under, the implied score for the game is Pirates 32, Roadrunners 30.
The Pirates have a 54.3% chance to collect the win in this game per the moneyline's implied probability. The Roadrunners have a 50.2% implied probability.
East Carolina has compiled a 6-4-0 ATS record so far this year.
UTSA has put together a 5-5-0 record against the spread this season.

East Carolina vs. UTSA: Head-to-Head

In their past two matchups, UTSA holds a split 1-1 record against East Carolina.
The last two times the Pirates have gone up against the Roadrunners, they have a 2-0 record against the spread. The scoring has gone over the point total on one occasion.
Over their last two head-to-head matchups, UTSA has racked up 61 points, while East Carolina has accumulated 57.

East Carolina vs. UTSA: 2025 Stats Comparison

	East Carolina	UTSA
Off. Points per Game (Rank)	33.6 (30)	32.3 (39)
Def. Points per Game (Rank)	18.3 (15)	30.4 (104)
Turnovers Allowed (Rank)	9 (13)	11 (43)
Turnovers Forced (Rank)	14 (51)	13 (57)

East Carolina 2025 Key Players

Name	Position	Stats
Katin Houser	QB	2,801 YDS (66.6%) / 15 TD / 5 INT 110 RUSH YDS / 7 RUSH TD / 11 RUSH YPG
London Montgomery	RB	637 YDS / 7 TD / 63.7 YPG / 5 YPC
Anthony Smith	WR	51 REC / 745 YDS / 4 TD / 74.5 YPG
Yannick Smith	WR	44 REC / 583 YDS / 5 TD / 58.3 YPG
Ja'Marley Riddle	DB	48 TKL / 3 TFL / 2 INT / 2 PD
Samuel Dankah	DL	41 TKL / 3 TFL / 1.5 SACK
Zion Wilson	DL	24 TKL / 5 TFL / 4 SACK
Jasiyah Robinson	DL	16 TKL / 3 TFL / 3.5 SACK

UTSA 2025 Key Players

Name	Position	Stats
Robert Henry	RB	983 YDS / 9 TD / 98.3 YPG / 7.1 YPC 17 REC / 112 REC YDS / 2 REC TD / 14 REC YPG
Owen McCown	QB	2,181 YDS (67.2%) / 20 TD / 6 INT -10 RUSH YDS / 1 RUSH TD / -1 RUSH YPG
Devin McCuin	WR	52 REC / 567 YDS / 7 TD / 56.7 YPG
Will Henderson III	RB	603 YDS / 4 TD / 60.3 YPG / 7 YPC 14 REC / 93 REC YDS / 1 REC TD / 11.6 REC YPG
Shadrach Banks	LB	62 TKL / 4 TFL / 1 SACK / 2 INT
Nnanna Anyanwu	LB	19 TKL / 7 TFL / 5 SACK
Jimmy Wyrick	DB	40 TKL / 0 TFL
Kendrick Blackshire	LB	36 TKL / 1 TFL / 1 SACK / 1 INT